Results 71 to 80 of about 3,252 (179)
Frontiers in NutritionThis project aims to investigate the release performance of bilayer tablet (BL-Tablet) designed with both fast and slow-release technology, targeting sleep disorders.
Rebecca Bassetto +10 more
doaj +1 more source
Effect of Gastric Fluid Volume on the in Vitro Dissolution and in Vivo Absorption of BCS Class II Drugs: A Case Study with Nifedipine [PDF]
, 2016 Nifedipine is a BCS Class II drug used for treatment of hypertension and preterm labor. Large inter-patient variability in nifedipine absorption results in variable exposure among different patients.
Fadda, Hala M. +3 more
core +2 more sources
Zeitschrift für anorganische und allgemeine Chemie, Volume 651, Issue 18, December 10, 2025.An iron(III)‐cumylperoxido intermediate has been generated that performs electrophilic and nucleophilic reactivity under ambient conditions. Iron‐containing alkylperoxido species are mostly unstable, although these are important reactive intermediates found in metalloenzymes.
Gunasekaran Velmurugan +4 more
wiley +1 more source
Glucosamine HCl-based solid dispersions to enhance the biopharmaceutical properties of acyclovir [PDF]
, 2019 The objective of the work presented here was to assess the feasibility of using glucosamine HCl as a solid-dispersion (SD) carrier to enhance the biopharmaceutical properties of a BCS class III/IV drug, acyclovir (ACV). The solid-dispersions of acyclovir
Bhagat, Snehal B. +6 more
core +1 more source
Evaluation of a Three Compartment In Vitro Gastrointestinal Simulator Dissolution Apparatus to Predict In Vivo Dissolution [PDF]
, 2014 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109359/1/jps24112 ...
Amidon, Gordon L. +3 more
core +1 more source
ChemistryOpen, Volume 14, Issue 12, December 2025.N‐terminal betaine conjugation modifies β‐peptide helices, influencing folding and self‐organization. For [1S, 2S]‐ACPC, folding to an H12 helix was unaffected, while [1R, 2R]‐ACHC formed an H14 helix instead of H10. Alternating heterochiral oligomers made of enantiomeric pairs of trans‐ACPC showed enhanced solubility and E‐strand formation.
Nikolett Varró +10 more
wiley +1 more source
DISSOLUTION MEDIA USED IN DEVELOPMENT AND QUALITY CONTROL OF DRUGS
Разработка и регистрация лекарственных средств, 2019 The main dissolution media recommended for the Dissolution test in Russia and abroad are represented in the review. Possible applications of biorelevant media and media with surfactants are also shown.
O. V. Druzhininskaya, I. E. Smekhova
doaj
Pharmaceutics, 2020 A small-scale biphasic dissolution setup and a small-scale dissolution-permeation (D-P) setup were evaluated for their usefulness in simulating the luminal precipitation of three lipophilic weak bases—dipyridamole, ketoconazole and itraconazole ...
Patrick J. O’Dwyer +3 more
doaj +1 more source
Evolution of a physiological pH 6.8 bicarbonate buffer system: application to the dissolution testing of enteric coated products. [PDF]
, 2011 The use of compendial pH 6.8 phosphate buffer to assess dissolution of enteric coated products gives rise to poor in vitro-in vivo correlations because of the inadequacy of the buffer to resemble small intestinal fluids.
Abdul W. Basit +44 more
core +1 more source
An Open‐Source Framework for Virtual Bioequivalence Modeling and Clinical Trial Design
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 12, Page 1932-1948, December 2025.ABSTRACT To establish bioequivalence (BE) of a generic test formulation with respect to a reference listed drug, it is necessary to demonstrate a comparable rate and extent to which active ingredients reach the site of action. To decrease unnecessary human testing and simulate scenarios involving specific populations or challenges with recruitment or ...
Abdullah Hamadeh +13 more
wiley +1 more source