Results 71 to 80 of about 224,448 (162)
Food Science &Nutrition, Volume 14, Issue 4, April 2026.Medium‐chain diacylglycerols were incorporated into fully hydrogenated palm kernel oil stearin (FHPKS) to regulate crystallization behavior and melt–dispersion performance. Low DAG levels (5%–10%) promoted β′‐rich crystal networks and improved thermal responsiveness, establishing a structure–property framework for designing functional lipid bases ...
Jun Jin, Mingxuan Fang, Siyu Zhang
wiley +1 more source
Biopharmaceutical relevance of dissolution profile comparison: Proposal of a combined approach [PDF]
, 2014 The aims of the present study were to evaluate the performance of the main methods proposed for the comparison of percentage dissolved versus time curves and to recommend a more biorelevant combined approach for the comparison of dissolution profiles of ...
Ruiz, María Esperanza +1 more
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Química Nova, 2010 An analytical method by liquid chromatography has been proposed and validated to study the apparent solubility of ibuprofen in biorelevant dissolution media.
Sandra M. Gómez +2 more
doaj +1 more source
Pharmaceutics, 2020 A small-scale biphasic dissolution setup and a small-scale dissolution-permeation (D-P) setup were evaluated for their usefulness in simulating the luminal precipitation of three lipophilic weak bases—dipyridamole, ketoconazole and itraconazole ...
Patrick J. O’Dwyer +3 more
doaj +1 more source
Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs
Advanced Healthcare Materials, Volume 15, Issue 5, 2 February 2026.Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner +8 more
wiley +1 more source
, 2010 Dissolution tests that can predict the in vivo performance of drug products are usually called biorelevant dissolution tests. Biorelevant dissolution testing can be used to guide formulation development, to identify food effects on the dissolution and ...
Fotaki, N., Vertzoni, M.
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Organic Electrochemical Transistors for Neuromorphic Devices and Applications
Advanced Materials, Volume 38, Issue 9, 12 February 2026.Organic electrochemical transistors are emerging as promising platforms for neuromorphic devices that emulate neuronal and synaptic activities and can seamlessly integrate with biological systems. This review focuses on resultant organic artificial neurons, synapses, and integrated devices, with an emphasis on their ability to perform neuromorphic ...
Kexin Xiang +4 more
wiley +1 more source
CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.ABSTRACT A high number of poorly soluble compounds are being developed; thus, understanding the factors that influence their absorption is critical. Intestinal bile salts, which facilitate micelle‐mediated solubilization, are particularly important for drugs with low solubility and are reported to be highly variable.
Laura G. Al‐Amiry Santos +2 more
wiley +1 more source
PharmaceuticsBackground/Objectives: 5-Fluorouracil (5-FU) and Irinotecan (IRT) are two of the most used chemotherapeutic agents in CRC treatment. However, achieving treatment goals has been hampered by poor drug delivery to tumor sites and associated toxicity from ...
Kafilat O. Agbaje +2 more
doaj +1 more source
Design and Evaluation of Two-Step Biorelevant Dissolution Methods for Docetaxel Oral Formulations. [PDF]
AAPS PharmSciTech, 2022 Shah B, Dong X.
europepmc +1 more source