Results 91 to 100 of about 1,723 (196)

In silico bioavailability for BCS class II efavirenz tablets using biorelevant dissolution media for IVIVR and simulation of formulation changes

, 2021
This work aims to evaluate the ability of biorelevant dissolution media to simulate the bioavailability of efavirenz tablets, establish an in vitro–in vivo relationship (IVIVR) based on in vivo data using GastroPlus® and simulate formulation changes ...
Beatriz Ferreira de Carvalho Patricio (11593257), Helvécio Vinícius Antunes Rocha (4749126), Thalita Martins da Silva (11593245), Marcelo Henrique da Cunha Chaves (11593251), Lucio Mendes Cabral (11593254), Thiago da Silva Honorio (11593248), Marcelo Dutra Duque (5188076)   +6 more
core   +1 more source

Simulation-guided dissolution testing: Coupling DDDPlus™ and GastroPlus® to predict aripiprazole oral bioperformance

Orally administered weakly basic compounds like aripiprazole (ARI) can precipitate in the small intestine due to limited solubility at intestinal pH.
Dobričić, Vladimir, Krstevska, Aleksandra, Ivković, Branka, Nedelkov, Ivana, Petrović, Maša, Cvijić, Sandra   +5 more
core   +1 more source

Immediate-Release Nifedipine Binary Dry Powder Mixtures with Nanocellulose Featuring Enhanced Solubility and Dissolution Rate

Pharmaceutics, 2019
Nifedipine (NIF) is a 1,4-dihydropyridine-based calcium channel blocker with poor solubility, whose bioavailability is highly dependent on the type of formulation.
Athanasios Mantas, Albert Mihranyan
doaj   +1 more source

Biopharmaceutical relevance of dissolution profile comparison: Proposal of a combined approach [PDF]

, 2019
The aims of the present study were to evaluate the performance of the main methods proposed for the comparison of percentage dissolved versus time curves and to recommend a more biorelevant combined approach for the comparison of dissolution profiles of ...
Ruiz, María Esperanza, Volonté, María Guillermina   +1 more
core  

Biorelevant intrinsic dissolution profiling in early drug development: Fundamental, methodological, and industrial aspects

, 2019
Intrinsic dissolution rate (IDR) is the surface specific dissolution rate of a drug. In early drug development, this property (among other parameters) is measured in order to compare different polymorphs and salt forms, guide formulation decisions, and ...
Schaefer, Kerstin J., Box, Karl, Matthews, Wayne, McAllister, Mark, Bergström, Christel,, Schäfer, Kerstin J.,, Mullertz, Anette, Rades, Thomas, Holm, Rene,, Matthews, Wayne,, Teleki, Alexandra, McAllister, Mark,, Teleki, Alexandra,, Box, Karl,, Rades, Thomas,, Mullertz, Anette,, Bergstrom, Christel A. S., Holm, Rene   +17 more
core   +1 more source

Dissolution properties of co-amorphous drug-amino acid formulations in buffer and biorelevant media

, 2015
Co-amorphous formulations, particularly binary drug-amino acid mixtures, have been shown to provide enhanced dissolution for poorly-soluble drugs and improved physical stability of the amorphous state.
DeClerck, L., Grohganz, H., Laitinen, R., Heikkinen, A. T., Löbmann, Korbinian, De Clerck, Laura, Löbmann, K., Rades, T.   +7 more
core  

Development of dissolution tests for the quality control of complementary/alternate and traditional medicines: Application to African potato products

Journal of Pharmacy & Pharmaceutical Sciences, 2008
- Purpose: Unlike orthodox medicines, specific guidelines for dissolution testing of complementary/alternate (CAMs) and traditional medicines (TMs) have not been developed nor is dissolution testing a requirement for the quality control of such products.
Vipin Devi Prasad Nair, Isadore Kanfer
doaj   +1 more source

SC Powder – domestic powder for the preparation of biorelevant media from the company Scientific Compliance

Разработка и регистрация лекарственных средств
The use of biorelevant dissolution media makes it possible to reproduce conditions as in the human gastrointestinal tract. This expands the capabilities of laboratories involved in the analysis of solid dosage forms and allows obtaining physiologically ...
article Editorial
doaj  

A biorelevant test for tablets glycine sublingual in the «simulated saliva» dissolution medium

Разработка и регистрация лекарственных средств
Introduction. Biorelevant dissolution media reconstitute the composition of the contents of the gastrointestinal tract. They are used as dissolution media in the evaluation of dissolution profiles of different dosage forms.
S. D. Kulikova, М. B. Sokol, Z. M. Kozlova, P. A. Losenkova, P. Ya. Parshinova, A. M. Poluyanov   +5 more
doaj   +1 more source

Applications of a Biorelevant In Vitro Dissolution Method Using USP Apparatus 4 in Early Phase Formulation Development [PDF]

, 2013
Dissolution plays various roles throughout drug development, including assessment of the lot-to-lot quality of a drug product, guidance for development of new formulations, and assurance of continuing product quality and performance throughout a drug's ...
Robertson, Vivian Ku
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