Results 91 to 100 of about 224,448 (162)

Simulation-guided dissolution testing: Coupling DDDPlus™ and GastroPlus® to predict aripiprazole oral bioperformance

Orally administered weakly basic compounds like aripiprazole (ARI) can precipitate in the small intestine due to limited solubility at intestinal pH.
Dobričić, Vladimir, Krstevska, Aleksandra, Ivković, Branka, Nedelkov, Ivana, Petrović, Maša, Cvijić, Sandra   +5 more
core   +1 more source

Dissolution Profile of Mefenamic Acid Solid Dosage Forms in Two Compendial and Biorelevant (FaSSIF) Media

, 2016
Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) that is widely used for the treatment of mild-to-moderate pain. Mefenamic acid belongs to the Biopharmaceutical Classification System (BCS) class II drug which has lower water solubility ...
Yeyet SUMIRTAPURA, Wilda NURHIKMAH, Jessie PAMUDJI   +2 more
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Biorelevant dissolution of poorly soluble weak acids studied by UV imaging reveals ranges of fractal-like kinetics.

, 2014
Much pharmaceutical research has been invested into drug dissolution testing and its mathematical modeling. Even today, there is no complete understanding of the dissolution process but novel imaging tools have been introduced into pharmaceutics that may
Niederquell A, Kuentz M
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The interplay of poorly soluble drugs in dissolution from amorphous solid dispersions

International Journal of Pharmaceutics: X
In recent years, the application of fixed dose combinations of antiretroviral drugs in HIV therapy has been established. Despite numerous therapeutic benefits, this approach poses several challenges for the formulation development especially when poorly ...
Marcel Kokott, Jörg Breitkreutz, Raphael Wiedey   +2 more
doaj   +1 more source

Prediction of food effects on the absorption of celecoxib based on biorelevant dissolution testing coupled with physiologically based pharmacokinetic modeling

, 2009
Since the rate-determining step to the intestinal absorption of poorly soluble drugs is the dissolution in the gastrointestinal (GI) tract, postprandial changes in GI physiology, in addition to any specific interactions between drug and food, are ...
Mao, Y., Janssen, N., Vertzoni, M., Reppas, C., Shono, Y., Dressman, J.B., Kesisoglou, F., Jantratid, E.   +7 more
core   +1 more source

A Comprehensive Study of Solid Lipid Microparticles (SLMs) Behavior in Biorelevant Dissolution Media

, 2013
The aim of this research was to study the release performance of solid lipid microparticles (SLMs) in various biorelevant dissolution media simulating the conditions of the gastric tract and the proximal human intestine.
DI SABATINO, MARCELLO, PASSERINI, NADIA, ALBERTINI, BEATRICE   +2 more
core   +1 more source

Evaluating the fed state impact on drug solubility and absorption : a biorelevant in vitro approach [PDF]

Biopharmaceutics, which studies the relationship between a drug's physical, chemical, biological, and pharmacological properties and its dosage form, is essential for studying and optimising oral formulations.
Silva, Maria Inês
core   +2 more sources

Biopharmaceutical relevance of dissolution profile comparison: Proposal of a combined approach [PDF]

, 2019
The aims of the present study were to evaluate the performance of the main methods proposed for the comparison of percentage dissolved versus time curves and to recommend a more biorelevant combined approach for the comparison of dissolution profiles of ...
Ruiz, María Esperanza, Volonté, María Guillermina   +1 more
core  

Biorelevant intrinsic dissolution profiling in early drug development: Fundamental, methodological, and industrial aspects

, 2019
Intrinsic dissolution rate (IDR) is the surface specific dissolution rate of a drug. In early drug development, this property (among other parameters) is measured in order to compare different polymorphs and salt forms, guide formulation decisions, and ...
Schaefer, Kerstin J., Box, Karl, Matthews, Wayne, McAllister, Mark, Bergström, Christel,, Schäfer, Kerstin J.,, Mullertz, Anette, Rades, Thomas, Holm, Rene,, Matthews, Wayne,, Teleki, Alexandra, McAllister, Mark,, Teleki, Alexandra,, Box, Karl,, Rades, Thomas,, Mullertz, Anette,, Bergstrom, Christel A. S., Holm, Rene   +17 more
core   +1 more source

Dissolution of Cavities and Porous Media: a Multi-Scale View [PDF]

, 2013
Dissolution of underground cavities or porous media involves many different scales that must be taken into account in modeling attempts. This paper presents a review of some of these problems.
Quintard, Michel
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