Results 91 to 100 of about 3,252 (179)

Development and Characterization of Optimized Drug-Loaded Niosomes for Delivery of 5-FU and Irinotecan

Pharmaceutics
Background/Objectives: 5-Fluorouracil (5-FU) and Irinotecan (IRT) are two of the most used chemotherapeutic agents in CRC treatment. However, achieving treatment goals has been hampered by poor drug delivery to tumor sites and associated toxicity from ...
Kafilat O. Agbaje, Simeon K. Adesina, Amusa S. Adebayo   +2 more
doaj   +1 more source

In vitro dissolution/release methods for mucosal delivery systems

ADMET and DMPK, 2017
In vitro dissolution/release tests are an indispensable tool in the drug product development, its quality control and the regulatory approval process.
Mario Jug, Anita Hafner, Jasmina Lovrić, Maja Lusina Kregar, Ivan Pepić, Željka Vanić, Biserka Cetina-Čižmek, Jelena Filipović-Grčić   +7 more
doaj   +1 more source

Design and Evaluation of Two-Step Biorelevant Dissolution Methods for Docetaxel Oral Formulations. [PDF]

AAPS PharmSciTech, 2022
Shah B, Dong X.
europepmc   +1 more source

Developing Clinically Relevant Dissolution Specifications for Oral Drug Products—Industrial and Regulatory Perspectives

Pharmaceutics, 2019
A meeting that was organized by the Academy of Pharmaceutical Sciences Biopharmaceutics and Regulatory Sciences focus groups focused on the challenges of Developing Clinically Relevant Dissolution Specifications (CRDS) for Oral Drug Products.
Mark McAllister, Talia Flanagan, Karin Boon, Xavier Pepin, Christophe Tistaert, Masoud Jamei, Andreas Abend, Evangelos Kotzagiorgis, Claire Mackie   +8 more
doaj   +1 more source

Kaempferol-Phospholipid Complex: Formulation, and Evaluation of Improved Solubility, In Vivo Bioavailability, and Antioxidant Potential of Kaempferol [PDF]

, 2016
The current work describes the formulation and evaluation of a phospholipid complex of kaempferol toenhance the latter’s aqueous solubility, in vitro dissolution rate, in vivo antioxidant and hepatoprotectiveactivities, and oral bioavailability.
Anand, Sridhar, Dave, Vivek S, Patil, Arun T., Pethe, Anil M., Tatode, Amol A., Telange, Darshan R.   +5 more
core   +2 more sources

Heat induced evaporative antisolvent nanoprecipitation (HIEAN) of itraconazole [PDF]

, 2014
YesItraconazole (ITR) is an antifungal drug with a limited bioavailability due to its poor aqueous solubility. In this study, ITR was used to investigate the impact of nanonisation and solid state change on drug’s apparent solubility and dissolution. A
Mugheirbi, N.A., Paluch, Krzysztof J., Tajber, L.   +2 more
core   +1 more source

In situ conjugation of dithiophenol maleimide polymers and oxytocin for stable and reversible polymer–peptide conjugates [PDF]

, 2015
The in situ one-pot synthesis of peptide–polymer bioconjugates is reported. Conjugation occurs efficiently without the need for purification of dithiophenol maleimide functionalized polymer as a disulfide bridging agent for the therapeutic oxytocin ...
Anderson M. E., Avanti C., Avanti C., Avanti C., Avanti C., Balan S., Berde B., Brocchini S., Broyer R. M., Castañeda L., David M. Haddleton, De Araujo A. D., Du Vigneaud V., Du Vigneaud V., Filpula D., Gard J. W., Greenwald R. B., Grover G. N., Harris J. M., Hawe A., Hogan M. C., Jennifer Collins, Joji Tanaka, Jones M. W., Jones M. W., Jones M. W., Jones M. W., Khan K. S., Knop K., Kristian Kempe, Le Droumaguet B., Manning M., Maughan K. L., Michael R. Whittaker, Michelle P. McIntosh, Moir C., Moody P., Muttenthaler M., Ohno A., Pasut G., Pasut G., Pasut G., Paul Wilson, Prankerd R. J., Robin M. P., Schumacher F. F., Shaunak S., Slavin S., Smith M. E. B., Stenzel M. H., Tedaldi L. M., Thomas P. Davis, Van Dongen P. W., Veronese F. M., Vrachnis N., Walter R., Wiśniewski K., Wiśniewski K., Zhang Q.   +58 more
core   +2 more sources

Immediate-Release Nifedipine Binary Dry Powder Mixtures with Nanocellulose Featuring Enhanced Solubility and Dissolution Rate

Pharmaceutics, 2019
Nifedipine (NIF) is a 1,4-dihydropyridine-based calcium channel blocker with poor solubility, whose bioavailability is highly dependent on the type of formulation.
Athanasios Mantas, Albert Mihranyan
doaj   +1 more source

Analysis of vaginal microbicide film hydration kinetics by quantitative imaging refractometry [PDF]

, 2014
We have developed a quantitative imaging refractometry technique, based on holographic phase microscopy, as a tool for investigating microscopic structural changes in water-soluble polymeric materials. Here we apply the approach to analyze the structural
A Akil, Adam Wax, AR Geonnotti, AR Neurath, AS Ham, B Rappaz, BA Miller-Chou, Bing Xu, DA Berk, David Katz, DF Katz, DL Kolin, G Popescu, HG Davies, JM Huntley, Lisa Rohan, Matthew Rinehart, MT Rinehart, NB Dobaria, NT Shaked, NT Shaked, O Frankman, PI Lee, Q Abdool Karim, R Barer, R Rustomjee, RM Machado, S Garg, S Garg, S Tasoglu, Sheila Grab, TT Tsay   +31 more
core   +2 more sources

Going Natural: Using polymers from nature for gastroresistant applications [PDF]

, 2017
Nutraceuticals provide an additional health or medicinal benefit besides their nutritional value and are therefore marketed for the prevention and treatment of certain conditions.
Barbara Conway, Hamid Merchant, Joao A.C. Barbosa, null null   +3 more
core   +1 more source