Results 81 to 90 of about 3,252 (179)
Química Nova, 2010 An analytical method by liquid chromatography has been proposed and validated to study the apparent solubility of ibuprofen in biorelevant dissolution media.
Sandra M. Gómez +2 more
doaj +1 more source
Photoinduced Reduction and Deuteration of Aryl Halides with NHC‐Boranes
European Journal of Organic Chemistry, Volume 28, Issue 43, November 24, 2025.A photoinduced radical reduction and deuteration of aryliodides and arylbromides is achieved using NHC‐borane without external initiators or photoredox catalysts. The reaction proceeds via aryl radicals and tolerates a broad range of functional groups, offering a practical and versatile approach for dehalogenation and isotopic labeling.
Gabin Lalande +4 more
wiley +1 more source
Molecular Nanosolids Generation by Vapor Jet Desublimation
Advanced Materials, Volume 37, Issue 47, November 27, 2025.A single‐step, solvent‐free approach to fabricate nanoparticles of small organic molecules is demonstrated, using a nitrogen‐propelled vapor jet, enabling tunable particle morphology and crystallinity. Pharmaceutical, flavoring, dyeing and electronics‐relevant molecules are used, demonstrating process generalizability.
Chao Huang +11 more
wiley +1 more source
Pharmaceutics, 2020 Amorphous solid dispersions (ASDs) have been proven to increase the bioavailability of poorly soluble drugs. It is desirable that the ASD provide a rapid dissolution rate and a sufficient stabilization of the generated supersaturation. In many cases, one
Marius Monschke, Karl G. Wagner
doaj +1 more source
Mechanistic Studies of Drug Dissolution Testing : Implications of solid phase properties and in vivo prognostic media [PDF]
, 2010 Drug absorption after oral administration requires that the drug first dissolves into gastro-intestinal tract liquids. In vivo dissolution of a drug is affected by physiological and drug-related physicochemical factors.
Lehto, Paula
core
The influence of non-ionisable excipients on precipitation parameters measured using the CheqSol method [PDF]
, 2016 Objectives: The aim of this study was to determine the influence of non-ionisable excipients hydroxypropyl--cyclodextrin (HPCD) and poloxamers 407 and 188 on the supersaturation and precipitation kinetics of ibuprofen, gliclazide, propranolol and ...
Elliott, Moira +2 more
core +1 more source
In‐Gel Generated Palladium Nanostructures as Bioorthogonal Uncaging Reactors
Advanced NanoBiomed Research, Volume 5, Issue 11, November 2025.Bioorthogonal chemistry holds promise to eliminate the side effects of current chemotherapies. Catalytic implants are needed that can convert harmless prodrugs into potent drugs locally near the tumor. Here, palladium nanocubes and nanosheets are formed within hydrogels and investigated for their effectiveness in uncaging a model compound through ...
Aisling McGuigan +4 more
wiley +1 more source
Nano Select, Volume 6, Issue 11, November 2025.Liposomes functionalized with tetraether lipids and cell‐penetrating peptides are explored as a platform technology for oral peptide delivery. Therefore, peptide drugs (GLP‐1 analogs) with different sizes and physicochemical properties are used as model drugs.
Lorenz Herbster +8 more
wiley +1 more source
In vitro dissolution of proton-pump inhibitor products intended for paediatric and geriatric use in physiological bicarbonate buffer [PDF]
, 2015 Peer reviewedFinal Accepted ...
Liu, Fang, Shokrollahi, Honaz
core +1 more source
Predicting human intestinal absorption in the presence of bile salt with micellar liquid chromatography [PDF]
, 2016 Understanding intestinal absorption for pharmaceutical compounds is vital to estimate bioavailability and therefore the in vivo potential of a drug.
Parkes, Gareth M.B +2 more
core +1 more source