Results 81 to 90 of about 224,448 (162)

Insights into the biopharmaceutical behavior of oral lipid-based formulations using advanced analytical techniques and mathematical modeling [PDF]

, 2014
Lipid-based formulations (LBFs) are effective means for the oral delivery of poorly water-soluble compounds. The drug is already solubilized in the formulation and, thus, the critical dissolution step is circumvented. However, the oral bioavailability is
Stillhart, Cordula Edith
core   +1 more source

Dissolution properties of co-amorphous drug-amino acid formulations in buffer and biorelevant media

, 2015
Co-amorphous formulations, particularly binary drug-amino acid mixtures, have been shown to provide enhanced dissolution for poorly-soluble drugs and improved physical stability of the amorphous state.
DeClerck, L., Grohganz, H., Laitinen, R., Heikkinen, A. T., Löbmann, Korbinian, Rades, T.   +5 more
core   +1 more source

In vitro dissolution/release methods for mucosal delivery systems

ADMET and DMPK, 2017
In vitro dissolution/release tests are an indispensable tool in the drug product development, its quality control and the regulatory approval process.
Mario Jug, Anita Hafner, Jasmina Lovrić, Maja Lusina Kregar, Ivan Pepić, Željka Vanić, Biserka Cetina-Čižmek, Jelena Filipović-Grčić   +7 more
doaj   +1 more source

Developing Clinically Relevant Dissolution Specifications for Oral Drug Products—Industrial and Regulatory Perspectives

Pharmaceutics, 2019
A meeting that was organized by the Academy of Pharmaceutical Sciences Biopharmaceutics and Regulatory Sciences focus groups focused on the challenges of Developing Clinically Relevant Dissolution Specifications (CRDS) for Oral Drug Products.
Mark McAllister, Talia Flanagan, Karin Boon, Xavier Pepin, Christophe Tistaert, Masoud Jamei, Andreas Abend, Evangelos Kotzagiorgis, Claire Mackie   +8 more
doaj   +1 more source

Immediate-Release Nifedipine Binary Dry Powder Mixtures with Nanocellulose Featuring Enhanced Solubility and Dissolution Rate

Pharmaceutics, 2019
Nifedipine (NIF) is a 1,4-dihydropyridine-based calcium channel blocker with poor solubility, whose bioavailability is highly dependent on the type of formulation.
Athanasios Mantas, Albert Mihranyan
doaj   +1 more source

88th Annual Meeting of the Meteoritical Society 2026: Abstracts

Meteoritics &Planetary Science, Volume 61, Issue S1, Page S48-S551, August 2026.
wiley   +1 more source

From In Vivo Predictive Dissolution to Virtual Bioequivalence: A GastroPlus^®-Driven Framework for Generic Candesartan Cilexetil Tablets

Pharmaceuticals
Background: Candesartan cilexetil, a Biopharmaceutics Classification System (BCS) II prodrug, demonstrates compromised bioavailability attributable to its limited aqueous solubility coupled with P-glycoprotein (P-gp)-mediated efflux and hepatic first ...
Hao Ruan, Xiaoting Geng, Zijing Situ, Qian Shen, Tianjian Ye, Xin Chen, Weike Su   +6 more
doaj   +1 more source

SC Powder – domestic powder for the preparation of biorelevant media from the company Scientific Compliance

Разработка и регистрация лекарственных средств
The use of biorelevant dissolution media makes it possible to reproduce conditions as in the human gastrointestinal tract. This expands the capabilities of laboratories involved in the analysis of solid dosage forms and allows obtaining physiologically ...
article Editorial
doaj  

Intrinsic Dissolution as a Tool for Evaluating Drug Solubility in Accordance with the Biopharmaceutics Classification System

, 2011
The Biopharmaceutics Classification System (BCS) is a tool that was created to categorize drugs into different groups according to their solubility and permeability characteristics.
ISSA, Michele G., FERRAZ, Humberto G.
core  

A biorelevant test for tablets glycine sublingual in the «simulated saliva» dissolution medium

Разработка и регистрация лекарственных средств
Introduction. Biorelevant dissolution media reconstitute the composition of the contents of the gastrointestinal tract. They are used as dissolution media in the evaluation of dissolution profiles of different dosage forms.
S. D. Kulikova, М. B. Sokol, Z. M. Kozlova, P. A. Losenkova, P. Ya. Parshinova, A. M. Poluyanov   +5 more
doaj   +1 more source