Results 81 to 90 of about 1,723 (196)

Dissolution testing of modified release products with biorelevant media: An OrBiTo ring study using the USP apparatus III and IV

, 2022
S.40-49During the OrBiTo project, our knowledge on the gastrointestinal environment has improved substantially and biorelevant media composition have been refined. The aim of this study was to propose optimized biorelevant testing conditions for modified
Williams, J., Tomaszewska, I., Karkossa, F., Vertzoni, M., Andreas, C.J., Rosenblatt, K., Winge, F., Klein, S., Karlsson, E., Dressman, J., Mistry, N., McAllister, M., Etherson, K., Smith, K.L., Hanley, S., Reppas, C., Vrettos, N.-N., Maier, G.-M., Schäfer, K.J., Miyaji, Y., Brown, J.   +20 more
core   +1 more source

Photoinduced Reduction and Deuteration of Aryl Halides with NHC‐Boranes

European Journal of Organic Chemistry, Volume 28, Issue 43, November 24, 2025.
A photoinduced radical reduction and deuteration of aryliodides and arylbromides is achieved using NHC‐borane without external initiators or photoredox catalysts. The reaction proceeds via aryl radicals and tolerates a broad range of functional groups, offering a practical and versatile approach for dehalogenation and isotopic labeling.
Gabin Lalande, Sandra Pinet, Frédéric Robert, Laurent Chabaud, Mathieu Pucheault   +4 more
wiley   +1 more source

Molecular Nanosolids Generation by Vapor Jet Desublimation

Advanced Materials, Volume 37, Issue 47, November 27, 2025.
A single‐step, solvent‐free approach to fabricate nanoparticles of small organic molecules is demonstrated, using a nitrogen‐propelled vapor jet, enabling tunable particle morphology and crystallinity. Pharmaceutical, flavoring, dyeing and electronics‐relevant molecules are used, demonstrating process generalizability.
Chao Huang, Eva Katharine Pontrelli, Jae Wan Lee, Binyu Wang, Ganlin Chen, Tatiane Cogo Machado, Hemanth Maddali, Benjamin De Chazal, Anish Tuteja, Ronald G. Larson, Naír Rodríguez‐Hornedo, Max Shtein   +11 more
wiley   +1 more source

A sustainable UPLC-UV method for quantification of donepezil hydrochloride in biorelevant media applied to dissolution profile comparison.

, 2020
Donepezil hydrochloride is one of the most prescribed anti-Alzheimer’s drugs, despite being available for more than two decades, chromatographic methods for the quantification of the drug in biorelevant media that mimics pH physiological conditions in ...
Campos, Débora Priscila de, Souza, Jacqueline de, Barcellos, Neila Marcia Silva, Lana, Victoria Luiza Vieira Vidigal, Barbosa, Guilherme Xavier, Marinho, Flávia Dias Marques   +5 more
core   +1 more source

Dissolution Profile of Mefenamic Acid Solid Dosage Forms in Two Compendial and Biorelevant (FaSSIF) Media

, 2016
Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) that is widely used for the treatment of mild-to-moderate pain. Mefenamic acid belongs to the Biopharmaceutical Classification System (BCS) class II drug which has lower water solubility ...
Yeyet SUMIRTAPURA, Wilda NURHIKMAH, Jessie PAMUDJI   +2 more
core   +1 more source

Development and Characterization of Optimized Drug-Loaded Niosomes for Delivery of 5-FU and Irinotecan

Pharmaceutics
Background/Objectives: 5-Fluorouracil (5-FU) and Irinotecan (IRT) are two of the most used chemotherapeutic agents in CRC treatment. However, achieving treatment goals has been hampered by poor drug delivery to tumor sites and associated toxicity from ...
Kafilat O. Agbaje, Simeon K. Adesina, Amusa S. Adebayo   +2 more
doaj   +1 more source

In vitro dissolution/release methods for mucosal delivery systems

ADMET and DMPK, 2017
In vitro dissolution/release tests are an indispensable tool in the drug product development, its quality control and the regulatory approval process.
Mario Jug, Anita Hafner, Jasmina Lovrić, Maja Lusina Kregar, Ivan Pepić, Željka Vanić, Biserka Cetina-Čižmek, Jelena Filipović-Grčić   +7 more
doaj   +1 more source

Developing Clinically Relevant Dissolution Specifications for Oral Drug Products—Industrial and Regulatory Perspectives

Pharmaceutics, 2019
A meeting that was organized by the Academy of Pharmaceutical Sciences Biopharmaceutics and Regulatory Sciences focus groups focused on the challenges of Developing Clinically Relevant Dissolution Specifications (CRDS) for Oral Drug Products.
Mark McAllister, Talia Flanagan, Karin Boon, Xavier Pepin, Christophe Tistaert, Masoud Jamei, Andreas Abend, Evangelos Kotzagiorgis, Claire Mackie   +8 more
doaj   +1 more source

Insights into the biopharmaceutical behavior of oral lipid-based formulations using advanced analytical techniques and mathematical modeling [PDF]

, 2014
Lipid-based formulations (LBFs) are effective means for the oral delivery of poorly water-soluble compounds. The drug is already solubilized in the formulation and, thus, the critical dissolution step is circumvented. However, the oral bioavailability is
Stillhart, Cordula Edith
core   +1 more source

Biorelevant dissolution methods and their applications in in vitroin vivo correlations for oral formulations

, 2010
Dissolution tests that can predict the in vivo performance of drug products are usually called biorelevant dissolution tests. Biorelevant dissolution testing can be used to guide formulation development, to identify food effects on the dissolution and ...
Fotaki, N., Vertzoni, M.
core