Results 61 to 70 of about 3,252 (179)

Magnetic resonance imaging quantification of fasted state colonic liquid pockets in healthy humans [PDF]

, 2017
The rate and extent of drug dissolution and absorption from solid oral dosage forms is highly dependent on the volume of liquid in the gastrointestinal tract (GIT).
Caroline L. Hoad, Deanna M. Mudie, EMA, EMA, FDA, FDA, Gordon L. Amidon, Gregory E. Amidon, Jeff Wright, Kathryn Murray, Khaled Heissam, Luca Marciani, Marciani L., Martin C. Garnett, Nichola Abrehart, Penny A. Gowland, Robin C. Spiller, Salem Al Atwah, Susan E. Pritchard   +18 more
core   +1 more source

Evaluating the Impact of Intestinal Bile Salts on Drug Absorption Using PBPK Modeling: Case Studies With Efavirenz, Cinnarizine, and Posaconazole

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT A high number of poorly soluble compounds are being developed; thus, understanding the factors that influence their absorption is critical. Intestinal bile salts, which facilitate micelle‐mediated solubilization, are particularly important for drugs with low solubility and are reported to be highly variable.
Laura G. Al‐Amiry Santos, Sebastian Polak, Karen Rowland Yeo   +2 more
wiley   +1 more source

Plasma modification of microporous polymer membranes for application in biomimetic dissolution studies

AAPS Open, 2017
Biorelevant dissolution is an indispensable tool utilized during formulation development and optimization for the prediction of in vivo bioavailability of pharmaceutical agents.
Michael M. Puppolo, Justin R. Hughey, Bruce Weber, Traciann Dillon, David Storey, Elizabeth Cerkez, Susan Jansen-Varnum   +6 more
doaj   +1 more source

Milk Modulates the Gastrointestinal Stability of Tick‐Borne Encephalitis Virus: Implications for Alimentary Transmission

Journal of Medical Virology, Volume 98, Issue 1, January 2026.
ABSTRACT Tick‐borne encephalitis virus (TBEV) can be transmitted alimentarily through contaminated dairy products, yet the mechanisms by which the virus survives the digestive tract remain poorly understood. In this study, we investigated the stability of TBEV in milk under simulated gastrointestinal conditions.
Martin Machacek, Michaela Berankova, Jiri Salat, Daniel Ruzek   +3 more
wiley   +1 more source

THE FEATURES OF THE PREDICTIVE DISSOLUTION TESTING (REVIEW)

Разработка и регистрация лекарственных средств, 2019
Dissolution test plays an important role at different levels of the development and manufacturing drugs as one of the major quality control tools and an integral part of In vitro tests in the study of drug release from the developed dosage forms. Article
R. I. Moustafine, A. V. Sitenkova (Bukhovets), N. Fotaki   +2 more
doaj  

Physiologically‐Based Pharmacokinetic Modeling to Support Pediatric Clinical Development: An IQ Working Group Perspective on the Current Status and Challenges

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 1, January 2026.
ABSTRACT Pediatric extrapolation strategies issued by health authorities have streamlined pediatric drug development and reduced the unnecessary burden of conducting pediatric clinical studies. In line with these strategies, physiologically based pharmacokinetic (PBPK) models have been utilized extensively for initial dosing regimen and sampling ...
James W. T. Yates, Michael Zientek, Kunal S. Taskar, Wen Lin, Tycho Heimbach, Stefan Willmann, Jessica Rehmel, Neil Parrott, Michael Hanley, Justine Badee, Yuan Chen, Susan Cole, Loeckie De Zwart, Sebastian Haertter, Rongrong Jiang, Masakatsu Kotsuma, Guiqing Liang, Yu‐Wei Lin, Jing Liu, Ying Ou, Juliane Rascher, Naveed A. Shaik, Jan Wahlstrom, Xiaofeng Wang, Guangqing Xiao, Ka Lai Yee, S. Y. Amy Cheung   +26 more
wiley   +1 more source

Applications of USP apparatus 3 in assessing the in vitro release of solid oral dosage forms

Brazilian Journal of Pharmaceutical Sciences, 2015
USP Apparatus 3 (reciprocating cylinder) is a very versatile device for the in vitro assessment of release characteristics of solid oral dosage forms, because it enables the product to be subjected to different dissolution media and agitation speeds in a
Bianca Ramos Pezzini, Michele Georges Issa, Marcelo Dutra Duque, Humberto Gomes Ferraz   +3 more
doaj   +1 more source

Statistical investigation of simulated fed intestinal media composition on the equilibrium solubility of oral drugs [PDF]

, 2017
Gastrointestinal fluid is a complex milieu and it is recognised that gut drug solubility is different to that observed in simple aqueous buffers. Simulated gastrointestinal media have been developed covering fasted and fed states to facilitate in vitro ...
Dunn, Claire, Halbert, Gavin W., Khadra, Ibrahim, Wilson, Clive G., Zhou, Zhou   +4 more
core   +1 more source

Toward Integrative Predictive Toxicology: Advanced Methods for Drug Toxicity and Safety Prediction

WIREs Computational Molecular Science, Volume 16, Issue 1, January/February 2026.
This figure summarizes the different methods in integrative predictive toxicology reviewed in this work, ranging from exploration of molecular mechanisms to in silico pharmacokinetic modeling and construction of adverse outcome pathway (AOP) networks based on key events (KEs) and key event relationships (KERs). Further integration with multi‐omics data
Eleonora Gianquinto, Matteo Bersani, Lucrezia Armando, Lara Davani, Clara Cena, Angela De Simone, Francesca Spyrakis   +6 more
wiley   +1 more source

The investigation of kinetics dissolution of prolonged indapamide drugs in biorelevant media

Сеченовский вестник, 2013
In the current work there was performed the development of the method of determination dissolution kinetics in biorelevant media of slightly soluble substance, for example indapamide. The method was validated in terms of specificity, linearity, precision,
E. Yu. Sannikova, A. A. Kruglyakova, I. E. Shokhin, G. V. Ramenskaya   +3 more
doaj