Results 61 to 70 of about 1,723 (196)

Drug release from matrix tablets: physiological parameters and the effect of food [PDF]

, 2014
Introduction: As dissolution plays an important and vital role in the drug-delivery process of oral solid dosage forms, it is, therefore, essential to critically evaluate the parameters that can affect this process. Areas covered: The consumption of
Ali Nokhodchi, Asare-Addo, Kofi, Kofi Asare-Addo, Nokhodchi, Ali, Ali Nokhodchi (4465915), Kofi Asare-Addo (4172488)   +5 more
core   +1 more source

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, Volume 15, Issue 5, 2 February 2026.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Plasma modification of microporous polymer membranes for application in biomimetic dissolution studies

AAPS Open, 2017
Biorelevant dissolution is an indispensable tool utilized during formulation development and optimization for the prediction of in vivo bioavailability of pharmaceutical agents.
Michael M. Puppolo, Justin R. Hughey, Bruce Weber, Traciann Dillon, David Storey, Elizabeth Cerkez, Susan Jansen-Varnum   +6 more
doaj   +1 more source

Organic Electrochemical Transistors for Neuromorphic Devices and Applications

Advanced Materials, Volume 38, Issue 9, 12 February 2026.
Organic electrochemical transistors are emerging as promising platforms for neuromorphic devices that emulate neuronal and synaptic activities and can seamlessly integrate with biological systems. This review focuses on resultant organic artificial neurons, synapses, and integrated devices, with an emphasis on their ability to perform neuromorphic ...
Kexin Xiang, Jiajun Song, Hong Liu, Junxin Chen, Feng Yan   +4 more
wiley   +1 more source

THE FEATURES OF THE PREDICTIVE DISSOLUTION TESTING (REVIEW)

Разработка и регистрация лекарственных средств, 2019
Dissolution test plays an important role at different levels of the development and manufacturing drugs as one of the major quality control tools and an integral part of In vitro tests in the study of drug release from the developed dosage forms. Article
R. I. Moustafine, A. V. Sitenkova (Bukhovets), N. Fotaki   +2 more
doaj  

Biorelevant dissolution models to assess precipitation of weak base drug

International Journal of Research in Pharmaceutical Sciences, 2020
The impact of precipitation can affect the amount of drug absorbed, thereby affecting the amount of drug in the systemic body. The precipitation process is preceded by a supersaturation phase, caused by decreased drug solubility in the gastrointestinal tract. This precipitation occurs for weak base drugs with low solubility.
null Viviane Annisa, null Teuku Nanda Saifullah Sulaiman, null Agung Endro Nugroho   +2 more
openaire   +1 more source

Evaluating the Impact of Intestinal Bile Salts on Drug Absorption Using PBPK Modeling: Case Studies With Efavirenz, Cinnarizine, and Posaconazole

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT A high number of poorly soluble compounds are being developed; thus, understanding the factors that influence their absorption is critical. Intestinal bile salts, which facilitate micelle‐mediated solubilization, are particularly important for drugs with low solubility and are reported to be highly variable.
Laura G. Al‐Amiry Santos, Sebastian Polak, Karen Rowland Yeo   +2 more
wiley   +1 more source

Applications of USP apparatus 3 in assessing the in vitro release of solid oral dosage forms

Brazilian Journal of Pharmaceutical Sciences, 2015
USP Apparatus 3 (reciprocating cylinder) is a very versatile device for the in vitro assessment of release characteristics of solid oral dosage forms, because it enables the product to be subjected to different dissolution media and agitation speeds in a
Bianca Ramos Pezzini, Michele Georges Issa, Marcelo Dutra Duque, Humberto Gomes Ferraz   +3 more
doaj   +1 more source

Milk Modulates the Gastrointestinal Stability of Tick‐Borne Encephalitis Virus: Implications for Alimentary Transmission

Journal of Medical Virology, Volume 98, Issue 1, January 2026.
ABSTRACT Tick‐borne encephalitis virus (TBEV) can be transmitted alimentarily through contaminated dairy products, yet the mechanisms by which the virus survives the digestive tract remain poorly understood. In this study, we investigated the stability of TBEV in milk under simulated gastrointestinal conditions.
Martin Machacek, Michaela Berankova, Jiri Salat, Daniel Ruzek   +3 more
wiley   +1 more source

Designing an effective dissolution test for bilayer tablets tailored for optimal melatonin release in sleep disorder management

Frontiers in Nutrition
This project aims to investigate the release performance of bilayer tablet (BL-Tablet) designed with both fast and slow-release technology, targeting sleep disorders.
Rebecca Bassetto, Emanuele Amadio, Francesco Ciampanelli, Stefano Perin, Pietro Ilari, Paolo Gaballo, Martina Callegari, Sara Feltrin, Jacopo Gobbo, Samuele Zanatta, Walter Bertin   +10 more
doaj   +1 more source