Results 61 to 70 of about 224,448 (162)

The investigation of kinetics dissolution of prolonged indapamide drugs in biorelevant media

Сеченовский вестник, 2013
In the current work there was performed the development of the method of determination dissolution kinetics in biorelevant media of slightly soluble substance, for example indapamide. The method was validated in terms of specificity, linearity, precision,
E. Yu. Sannikova, A. A. Kruglyakova, I. E. Shokhin, G. V. Ramenskaya   +3 more
doaj  

Charge Regulation in Crowded Solutions of a Weak Polyelectrolyte: Steric Interactions

Israel Journal of Chemistry, Volume 66, Issue 3, May 2026.
Weak polyelectrolytes (WPE) solvated in biorelevant media and synthetic complex fluids that contain substantial concentrations of macromolecules, molecular assemblies, and nanoparticles are observed to exhibit deviations from the acid–base equilibrium observed in single‐component solutions.
David Attia, Evgenee Yekymov, Rachel Yerushalmi‐Rozen   +2 more
wiley   +1 more source

PBPK modeling coupled with biorelevant dissolution to forecast the oral performance of amorphous solid dispersion formulations

, 2022
S.83-90The aim of this research was to develop an in silico modeling and simulation approach to predict the oral performance of a poorly soluble drug candidate, T2CP, formulated as an amorphous solid dispersion and an amorphous powder.
Fujiwara, M., Kambayashi, A., Kiyota, T., Dressman, J.   +3 more
core   +1 more source

Applications of USP apparatus 3 in assessing the in vitro release of solid oral dosage forms

Brazilian Journal of Pharmaceutical Sciences, 2015
USP Apparatus 3 (reciprocating cylinder) is a very versatile device for the in vitro assessment of release characteristics of solid oral dosage forms, because it enables the product to be subjected to different dissolution media and agitation speeds in a
Bianca Ramos Pezzini, Michele Georges Issa, Marcelo Dutra Duque, Humberto Gomes Ferraz   +3 more
doaj   +1 more source

Randomized, Placebo‐Controlled, First‐in‐Human Study of the Safety, Tolerability, and Pharmacokinetics of Single and Repeat Oral Doses of Novel Antitubercular Drug Candidate, GSK2556286, in Healthy Adults

The Journal of Clinical Pharmacology, Volume 66, Issue 5, May 2026.
Abstract This first‐in‐human study (ClinicalTrials.gov identifier: NCT04472897) evaluated the safety, tolerability, pharmacokinetics, and food effect of single ascending and repeat oral doses of GSK2556286 (GSK286), a novel antitubercular drug candidate with efficacy in animal models of tuberculosis.
Emma Ilsley, Edward Banham‐Hall, Tetyana Chaychenko, Katerina Chinenyeze, Gareth Maher‐Edwards, Catherine Muya, Katie Rolfe, Raman Sharma, Simon Tiberi, David Barros‐Aguirre   +9 more
wiley   +1 more source

Uracil–Peptide–Pyrene Conjugates as Cu2+‐Sensitive Probes Targeting DNA, RNA, and Biorelevant Model Membranes

ChemBioChem, Volume 27, Issue 8, April 2026.
We introduce uracil–triazole–pyrene peptidomimetics whose tunable peptide linkers precisely control light emission, copper binding, and interactions with DNA and RNA. Fine structural adjustments unlock selective biomolecular recognition and striking metal‐ and membrane‐responsive fluorescence, paving the way for a new generation of multifunctional ...
Dijana Pavlović Saftić, Lucija Lulić Horvat, Ivo Piantanida   +2 more
wiley   +1 more source

Designing an effective dissolution test for bilayer tablets tailored for optimal melatonin release in sleep disorder management

Frontiers in Nutrition
This project aims to investigate the release performance of bilayer tablet (BL-Tablet) designed with both fast and slow-release technology, targeting sleep disorders.
Rebecca Bassetto, Emanuele Amadio, Francesco Ciampanelli, Stefano Perin, Pietro Ilari, Paolo Gaballo, Martina Callegari, Sara Feltrin, Jacopo Gobbo, Samuele Zanatta, Walter Bertin   +10 more
doaj   +1 more source

Nickel(0)‐Catalyzed [2+2+2] Cycloadditions of Linked Bisdiynes with Diaryl Alkynes Generates D‐π‐A‐π‐D Bis(arylethynyl)indane‐Based Organic Frameworks as Noncytotoxic Probes for Ds‐DNA/Ds‐RNA

ChemistryEurope, Volume 4, Issue 4, April 2026.
Ni(0)‐catalyzed [2 + 2 + 2] cycloadditions of linked bisdiynes with diarylacetylenes generate highly fluorescent D‐π‐A‐π‐D bis(arylethynyl)indane dyes. They bind strongly to ds‐DNA and ‐RNA leading to significant fluorescence quenching, are nontoxic toward human cell lines, and have potential as multimodal fluorescence, CD, and Raman probes for ...
Robert Ricker, Dijana Pavlović Saftić, Sabine Lorenzen, Johannes Schneider, Alena Neudert, Michelle Kalizki, Johannes Krebs, Florian Kerner, Alexandra Friedrich, Ludwig Zapf, Nils Schopper, Maik Finze, Nina Vukadinović, Lucija Lulić Horvat, Ivo Piantanida, Todd B. Marder   +15 more
wiley   +1 more source

Uv Spectrophotometric Method For Determination Of The Dissolution Profile Of Rivaroxaban

, 2014
Rivaroxaban is an oral anticoagulant that is the first available orally active direct Factor Xa inhibitor. In this study, a UV spectrophotometric method was developed for the determination of rivaroxaban content in pharmaceutical formulations and the ...
Celebier, Mustafa, Kaynak, Mustafa Sinan, Sahin, Selma, Altinoz, Sacide   +3 more
core   +1 more source

DISSOLUTION MEDIA USED IN DEVELOPMENT AND QUALITY CONTROL OF DRUGS

Разработка и регистрация лекарственных средств, 2019
The main dissolution media recommended for the Dissolution test in Russia and abroad are represented in the review. Possible applications of biorelevant media and media with surfactants are also shown.
O. V. Druzhininskaya, I. E. Smekhova
doaj