Results 81 to 90 of about 455 (133)

In‐Depth Analysis of the Selection of PBPK Modeling Tools: Bibliometric and Social Network Analysis of the Open Systems Pharmacology Community

The Journal of Clinical Pharmacology, Volume 64, Issue 9, Page 1055-1067, September 2024.
Abstract Since the Open Source Initiative laid the foundation for the open source software environment in 1998, the popularity of free and open source software has been steadily increasing. Model‐informed drug discovery and development (MID3), a key component of pharmaceutical research and development, heavily makes use of computational models which ...
André Dallmann, Donato Teutonico, Stephan Schaller, Rolf Burghaus, Sebastian Frechen   +4 more
wiley   +1 more source

Tipifarnib physiologically‐based pharmacokinetic modeling to assess drug–drug interaction, organ impairment, and biopharmaceutics in healthy subjects and cancer patients

CPT: Pharmacometrics &Systems Pharmacology, Volume 13, Issue 8, Page 1366-1379, August 2024.
Abstract A physiologically‐based pharmacokinetic (PBPK) model for tipifarnib, which included mechanistic absorption, was built and verified by integrating in vitro data and several clinical data in healthy subjects and cancer patients. The final PBPK model was able to recover the clinically observed single and multiple‐dose plasma concentrations of ...
Noriko Okudaira, Howard Burt, Amitava Mitra   +2 more
wiley   +1 more source

Physiologically Based Pharmacokinetic and Physiologically Based Biopharmaceutic models research in Latin America: A regional level bibliometric analysis, 2011-2023 [PDF]

Brazilian Journal of Pharmaceutical Sciences
The landscape of scientific research in Latin America (LA), particularly in the realms of the Physiologically Based Pharmacokinetic (PBPK) and Physiologically Based Biopharmaceutic models (PBPM), is a mosaic of varied contributions, collaborations, and ...
Marx Ribeiro, Juliana Cordeiro Cardoso, José Eduardo Severino Martins, Aline Ferreira Pinto, Eliana Maria Barbosa Souto, Patricia Severino   +5 more
doaj   +1 more source

Physiologically Based Biopharmaceutics Modeling (PBBM) to Evaluate the Biopredictive Power of Dissolution Methods for Rivaroxaban Tablets

The aim of this study was to use the physiologically based biopharmaceutics modeling (PBBM) strategy to evaluate the biopredictive power of different dissolution test conditions for immediate release tablets containing 20 mg of rivaroxaban. The model was developed and validated with literature data and used to predict plasma concentration-time curves ...
Eduardo Nabais de Carvalho Lauro, Bruna Wenyi Chuang Jou, Humberto Gomes Ferraz, Michele Georges Issa, Marcelo Dutra Duque   +4 more
openaire   +1 more source

Development of Physiologically Based Biopharmaceutical Model (PBBM) for Felodipine Prolonged-Release Tablet as useful tool for prediction of formulation.

International Journal For Multidisciplinary Research
Physiologically Based Biopharmaceutical Models (PBBMs) are advanced tools that integrate physiological parameters with drug-specific properties to simulate drug behavior in vivo. In this study, we present the development of a PBBM specifically tailored for felodipine prolonged-release (PR) tablet formulations.
Pramod V Kadam -, Dr K Lakshmi -, Dr Rajkumar M -   +2 more
openaire   +1 more source

In vitro two stage one compartment dumping test data and absorption/formulation PBBM modeling to explain a bioequivalence failure of valsartan formulations

European Journal of Pharmaceutics and Biopharmaceutics
In recent years, significant efforts have been made to develop new dissolution methods capable of predicting the in vivo behavior of pharmaceutical formulations. This is essential for establishing valid in vitro-in vivo correlations (IVIVCs) and biopredictive models.
Bárbara Sánchez-Dengra, Alejandro Ruiz-Picazo, Isabel Gonzalez-Alvarez, Marta Gonzalez-Alvarez, Marival Bermejo   +4 more
openaire   +2 more sources

Development of a novel physiologically based biopharmaceutics modeling (PBBM) framework using the open systems pharmacology suite, part 1: in vitro modeling of vericiguat

European Journal of Pharmaceutical Sciences
Physiologically Based Biopharmaceutics Modeling (PBBM) links in vitro solubility and dissolution kinetics of oral drugs to Physiologically Based Pharmacokinetic (PBPK) models, enabling the prediction of drug bioavailability. This approach reduces reliance on animal experimentation during drug development.
Paul Vrenken, Maria Vertzoni, Sebastian Frechen, Juri Solodenko, Michaela Meyer, Uwe Muenster, André Dallmann   +6 more
openaire   +2 more sources

Development of Mechanistic In Vitro–In Vivo Extrapolation to Support Bioequivalence Assessment of Long-Acting Injectables

Pharmaceutics
Long-acting injectable (LAI) formulations provide sustained drug release over an extended period ranging from weeks to several months to improve efficacy, safety, and compliance.
Daniela Amaral Silva, Maxime Le Merdy, Khondoker Dedarul Alam, Yan Wang, Quanying Bao, Nilesh Malavia, Diane Burgess, Viera Lukacova   +7 more
doaj   +1 more source

Development of a novel physiologically based biopharmaceutics modeling (PBBM) framework using the open systems pharmacology suite, part 2: in vivo pharmacokinetic modeling of vericiguat

European Journal of Pharmaceutical Sciences
This manuscript introduces a novel, free and open-source physiologically based biopharmaceutics modeling (PBBM) workflow to support decision-making during oral drug product development. Developed within the Open Systems Pharmacology (OSP) framework, this workflow combines three open-source tools to predict in vivo absorption by integrating solubility ...
Paul Vrenken, Maria Vertzoni, Sebastian Frechen, Juri Solodenko, Michaela Meyer, Uwe Muenster, André Dallmann   +6 more
openaire   +2 more sources

SME Factors peruntuk RM200j bantu PKS [PDF]

, 2012
KOLABORASI antara SME Factors Sdn Bhd bersama PBBM Global Corporation Berhad (PGC) bagi tujuan pemfaktoran kemudahan bernilai RM200 juta, menjadi penyumbang pembangunan perusahaan kecil dan sederhana (PKS) di ...
Azhar, Nurainn
core   +1 more source