Results 61 to 70 of about 455 (133)

Food and bile micelle binding of quaternary ammonium compounds

ADMET and DMPK, 2023
Background and Purpose: Physiologically-based biopharmaceutics modeling (PBBM) has been widely used to predict the oral absorption of drugs. However, the prediction of food effects on oral drug absorption is still challenging, especially for negative ...
Sumiji Takeru, Kiyohiko Sugano
doaj   +1 more source

Development and evaluation of a new Psysiologically Based Biopharmaceutics Modeling ( PBBM) approach for predicting oral drug product performance using th Open Systems Pharmacology Suite.

Η χορήγηση φαρμάκων από το στόμα είναι η προτιμότερη οδός χορήγησης σε σχέση με τις άλλες οδούς λόγω της υψηλής συμμόρφωσης των ασθενών. Η ανάπτυξη νέων per os χορηγούμενων φαρμακευτικών προϊόντων συνοδεύεται από προκλήσεις δεδομένου ότι η απορρόφηση από το γαστρεντερικό σύστημα είναι μια πολύπλοκη διαδικασία ιδιαίτερα για τις δραστικές φαρμακευτικές ...
Vrenken Paul, Vrenken Paul
core   +3 more sources

Finger Vein Recognition Based on Anatomical Features of Vein Patterns

IEEE Access, 2023
Finger vein recognition is a promising biometric authentication technique that depends on the unique features of vein patterns in the finger for recognition.
Arya Krishnan, Tony Thomas
doaj   +1 more source

In-Depth Analysis of Physiologically Based Pharmacokinetic (PBPK) Modeling Utilization in Different Application Fields Using Text Mining Tools

Pharmaceutics, 2022
In the past decade, only a small number of papers have elaborated on the application of physiologically based pharmacokinetic (PBPK) modeling across different areas. In this review, an in-depth analysis of the distribution of PBPK modeling in relation to
Aleksandra Krstevska, Jelena Đuriš, Svetlana Ibrić, Sandra Cvijić   +3 more
doaj   +1 more source

SMEsuccess bantu kontraktor: PBBM beri kerjasama peruntuk dana RM200 juta untuk lancar skim [PDF]

, 2012
SME Factors Sdn Bhd melancarkan SMEsuccess, iaitu kemudahan pemfaktoran yang dikhususkan untuk vendor serta kontraktor yang mendapat kontrak atau projek daripada agensi yang menjadi ahli Persatuan Badan Berkanun Malaysia (PBBM)
Alias, Che Wan Badrul
core   +1 more source

Tough Bioplastics from Babassu Oil-Based Acrylic Monomer, Hemicellulose Xylan, and Carnauba Wax

, 2023
We describe here the fabrication, characterization, and properties of tough bioplastics made of a babassu oil-based acrylic polymer (PBBM), hemicellulose xylan grafted with PBBM chains, and carnauba wax (CW).
Yehor Polunin, Igor Luzinov, Vasylyna Kirianchuk, Najah Mhesn, Andriy Voronov, Sergiy Minko, Liying Wei   +6 more
core   +1 more source

Utilization of in silico tools to investigate the in vivo performance of vildagliptin modified release (MR) 100 mg tablets in healthy subjects using physiologically based biopharmaceutics modeling (PBBM) and evaluate an approach to establish clinically relevant dissolution specifications

, 2022
The objective of the study was to predict pharmacokinetic (PK) and pharmacodynamic (PD) parameters of matrix based modified release (MR) drug product of vildagliptin.
Ahmed Madny, Muzaffaruddin, Borde, Parag Prakash, Tumuluri, Sri Venkata, Deshpande, Pandurang, Sangana, Ramachandra   +4 more
core   +1 more source

Power of integrating PBPK with PBBM (PBPK-BM): a single model predicting food effect, gender impact, drug-drug interactions and bioequivalence in fasting & fed conditions

Xenobiotica, 2023
Over the past few years, PBPK and PBBM modelling have proven their significance in drug development. PBPK modelling is traditionally used to predict drug-drug interactions, exposures in special populations whereas PBBM modelling is a part of PBPK modelling that is used for a range of biopharmaceutics applications.Because of these differences in ...
Rajkumar, Boddu, Sivacharan, Kollipara, Gautam, Vijaywargi, Tausif, Ahmed   +3 more
openaire   +2 more sources

Simulation of oral absorption from non-bioequivalent dosage forms of the salt of raltegravir, a poorly soluble acidic drug, using a physiologically based biopharmaceutical modeling (PBBM) approach

European Journal of Pharmaceutical Sciences, 2021
Non-bioequivalent plasma concentration profiles among different dosage forms of the salt of raltegravir, a poorly soluble acidic drug, were investigated using biorelevant in vitro testing combined with the commercial in silico software, Simcyp®. A suspension and a tablet dosage forms of raltegravir potassium were selected as the test formulations ...
Takao, Komasaka, Jennifer, Dressman
openaire   +2 more sources

Using PBPK to Simulate Target Biopredictive Dissolution Profiles for Long‐Acting Injectables ‐ Where to Begin With Critical Bioavailability Attributes?

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 3, March 2026.
ABSTRACT Long‐acting injectables (LAI) are of increasing interest as they facilitate improved medication adherence and exposure, with target plasma concentration levels maintained over weeks/months. Biopredictive in vitro dissolution tests can aid formulation development of LAIs and guide quality control dissolution testing by facilitating accelerated ...
Hannah Cleary, Nikoletta Fotaki, Tim Persoons, Deirdre M. D'Arcy   +3 more
wiley   +1 more source