Results 51 to 60 of about 278 (111)

Finger Vein Recognition Based on Anatomical Features of Vein Patterns

IEEE Access, 2023
Finger vein recognition is a promising biometric authentication technique that depends on the unique features of vein patterns in the finger for recognition.
Arya Krishnan, Tony Thomas
doaj   +1 more source

In-Depth Analysis of Physiologically Based Pharmacokinetic (PBPK) Modeling Utilization in Different Application Fields Using Text Mining Tools

Pharmaceutics, 2022
In the past decade, only a small number of papers have elaborated on the application of physiologically based pharmacokinetic (PBPK) modeling across different areas. In this review, an in-depth analysis of the distribution of PBPK modeling in relation to
Aleksandra Krstevska, Jelena Đuriš, Svetlana Ibrić, Sandra Cvijić   +3 more
doaj   +1 more source

Simulation of oral absorption from non-bioequivalent dosage forms of the salt of raltegravir, a poorly soluble acidic drug, using a physiologically based biopharmaceutical modeling (PBBM) approach

European Journal of Pharmaceutical Sciences, 2021
Non-bioequivalent plasma concentration profiles among different dosage forms of the salt of raltegravir, a poorly soluble acidic drug, were investigated using biorelevant in vitro testing combined with the commercial in silico software, Simcyp®. A suspension and a tablet dosage forms of raltegravir potassium were selected as the test formulations ...
Takao, Komasaka, Jennifer, Dressman
openaire   +2 more sources

Using PBPK to Simulate Target Biopredictive Dissolution Profiles for Long‐Acting Injectables ‐ Where to Begin With Critical Bioavailability Attributes?

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 3, March 2026.
ABSTRACT Long‐acting injectables (LAI) are of increasing interest as they facilitate improved medication adherence and exposure, with target plasma concentration levels maintained over weeks/months. Biopredictive in vitro dissolution tests can aid formulation development of LAIs and guide quality control dissolution testing by facilitating accelerated ...
Hannah Cleary, Nikoletta Fotaki, Tim Persoons, Deirdre M. D'Arcy   +3 more
wiley   +1 more source

A Combined Modeling Approach to Predict the Effect of Gastric Emptying Delay on the Pharmacokinetics of Small Molecules

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 12, Page 2026-2039, December 2025.
ABSTRACT Dulaglutide, a long‐acting glucagon‐like peptide‐1 (GLP‐1) receptor agonist, is approved for improving glycemic control and reducing cardiovascular risks in patients with type 2 diabetes mellitus (T2DM). This research investigates the effect of dulaglutide on gastric emptying and its impact on the pharmacokinetics (PK) of orally administered ...
Maria M. Posada, Karen B. Schneck, Bridget L. Morse, Luc R. A. Rougee, Lai San Tham, Jessica F. Rehmel, Brian Thompson, Stephen D. Stamatis, Stephen D. Hall, Gemma L. Dickinson   +9 more
wiley   +1 more source

An Open‐Source Framework for Virtual Bioequivalence Modeling and Clinical Trial Design

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 12, Page 1932-1948, December 2025.
ABSTRACT To establish bioequivalence (BE) of a generic test formulation with respect to a reference listed drug, it is necessary to demonstrate a comparable rate and extent to which active ingredients reach the site of action. To decrease unnecessary human testing and simulate scenarios involving specific populations or challenges with recruitment or ...
Abdullah Hamadeh, Moriah Pellowe, Pierre Chelle, Cindy Hoi Ting Yeung, Julian Otalvaro, Walter Yamada, Jay Bartroff, Alona Kryshchenko, André Dallmann, Juri Solodenko, Jörg Lippert, Eleftheria Tsakalozou, Michael Neely, Andrea Edginton   +13 more
wiley   +1 more source

Application of the Gastrointestinal Simulator (GIS) Coupled with In Silico Modeling to Measure the Impact of Coca-Cola^® on the Luminal and Systemic Behavior of Loratadine (BCS Class 2b)

Pharmaceutics, 2020
In the present work, we explored if Coca-Cola® had a beneficial impact on the systemic outcome of the weakly basic drug loratadine (Wal-itin®, immediate-release formulation, 10 mg, generic drug product).
Bart Hens, Marival Bermejo, Patrick Augustijns, Rodrigo Cristofoletti, Gregory E. Amidon, Gordon L. Amidon   +5 more
doaj   +1 more source

Using molecularly dissolved drug concentrations in PBBMs improves the prediction of oral absorption from supersaturating formulations

European Journal of Pharmaceutical Sciences
Predicting the absorption of drugs from enabling formulations is still challenging due to the limited capabilities of standard physiologically based biopharmaceutics models (PBBMs) to capture complex absorption processes. Amongst others, it is often assumed that both, molecularly and apparently dissolved drug in the gastrointestinal lumen are prone to ...
Holzem, Florentin Lukas, Petrig Schaffland, Jeannine, Brandl, Martin, Bauer-Brandl, Annette, Stillhart, Cordula   +4 more
openaire   +2 more sources

In‐Depth Analysis of the Selection of PBPK Modeling Tools: Bibliometric and Social Network Analysis of the Open Systems Pharmacology Community

The Journal of Clinical Pharmacology, Volume 64, Issue 9, Page 1055-1067, September 2024.
Abstract Since the Open Source Initiative laid the foundation for the open source software environment in 1998, the popularity of free and open source software has been steadily increasing. Model‐informed drug discovery and development (MID3), a key component of pharmaceutical research and development, heavily makes use of computational models which ...
André Dallmann, Donato Teutonico, Stephan Schaller, Rolf Burghaus, Sebastian Frechen   +4 more
wiley   +1 more source

Tipifarnib physiologically‐based pharmacokinetic modeling to assess drug–drug interaction, organ impairment, and biopharmaceutics in healthy subjects and cancer patients

CPT: Pharmacometrics &Systems Pharmacology, Volume 13, Issue 8, Page 1366-1379, August 2024.
Abstract A physiologically‐based pharmacokinetic (PBPK) model for tipifarnib, which included mechanistic absorption, was built and verified by integrating in vitro data and several clinical data in healthy subjects and cancer patients. The final PBPK model was able to recover the clinically observed single and multiple‐dose plasma concentrations of ...
Noriko Okudaira, Howard Burt, Amitava Mitra   +2 more
wiley   +1 more source