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Results 41 to 50 of about 773 (143)

Physiologically based pharmacokinetic modeling and simulations to inform dissolution specifications and clinical relevance of release rates on elagolix exposure

Biopharmaceutics &Drug Disposition, Volume 43, Issue 3, Page 98-107, June 2022., 2022
This analysis used a physiologically based pharmacokinetic model to predict the impact of changes in dissolution rates on elagolix exposures and define clinically relevant acceptance criteria for dissolution. The simulation results indicated that a slower in vitro dissolution profile would not have clinically significant impact on elagolix exposures ...
Dwaipayan Mukherjee +5 more
wiley +1 more source

Development of Extended-Release Mini-Tablets Containing Metoprolol Supported by Design of Experiments and Physiologically Based Biopharmaceutics Modeling

Pharmaceutics, 2022
The development of extended-release dosage forms with adequate drug release is a challenge for pharmaceutical companies, mainly when the drug presents high solubility, as in Biopharmaceutics Classification System (BCS) class I.
Michele Georges Issa +4 more
doaj +1 more source

Finger Vein Recognition Based on a Personalized Best Bit Map

Sensors, 2012
Finger vein patterns have recently been recognized as an effective biometric identifier. In this paper, we propose a finger vein recognition method based on a personalized best bit map (PBBM).
Yilong Yin, Xiaoming Xi, Gongping Yang
doaj +1 more source

A note on tsunamis: their generation and propagation in an ocean of uniform depth [PDF]

, 1973
The waves generated in a two-dimensional fluid domain of infinite lateral extent and uniform depth by a deformation of the bounding solid boundary are investigated both theoretically and experimentally.
Hammack, Joseph L.
core +1 more source

CIBERER: Spanish national network for research on rare diseases: A highly productive collaborative initiative

Clinical Genetics, Volume 101, Issue 5-6, Page 481-493, May-June 2022., 2022
Abstract CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in ...
Juan Luque +371 more
wiley +1 more source

Fitting the pair potentials for molten salts: A review in brief [PDF]

, 2023
In vitro and in silico studies should supplement each other in order to obtain reliable and comprehensive data on physicochemical properties of molten salts. To attain the aim, the appropriate simulation technique is needed.
Zakiryanov, Dmitry O.
core +2 more sources

Effect of food on capsule and granule formulations of selumetinib

Clinical and Translational Science, Volume 15, Issue 4, Page 878-888, April 2022., 2022
Abstract Selumetinib is an oral, potent, and highly selective allosteric MEK1/2 inhibitor approved for the treatment of pediatric patients (aged ≥2 years) with neurofibromatosis type 1 who have symptomatic, inoperable plexiform neurofibromas. A granule formulation of selumetinib is under development to improve dosing precision for younger pediatric ...
Sarit Cohen‐Rabbie +4 more
wiley +1 more source

Biochemistry of methanol‐dependent acetogenesis in Eubacterium callanderi KIST612

Environmental Microbiology, Volume 23, Issue 8, Page 4505-4517, August 2021., 2021
Summary Methanol is the simplest of all alcohols, is universally distributed in anoxic sediments as a result of plant material decomposition and is constantly attracting attention as an interesting substrate for anaerobes like acetogens that can convert bio‐renewable methanol into value‐added chemicals.
Helge M. Dietrich +4 more
wiley +1 more source

Using PBPK to Simulate Target Biopredictive Dissolution Profiles for Long-Acting Injectables - Where to Begin With Critical Bioavailability Attributes? [PDF]

CPT Pharmacometrics Syst Pharmacol
ABSTRACT Long‐acting injectables (LAI) are of increasing interest as they facilitate improved medication adherence and exposure, with target plasma concentration levels maintained over weeks/months. Biopredictive in vitro dissolution tests can aid formulation development of LAIs and guide quality control dissolution testing by facilitating accelerated ...
Cleary H, Fotaki N, Persoons T, D'Arcy DM. +3 more
europepmc +2 more sources

Developing Clinically Relevant Dissolution Specifications for Oral Drug Products—Industrial and Regulatory Perspectives

Pharmaceutics, 2019
A meeting that was organized by the Academy of Pharmaceutical Sciences Biopharmaceutics and Regulatory Sciences focus groups focused on the challenges of Developing Clinically Relevant Dissolution Specifications (CRDS) for Oral Drug Products.
Mark McAllister +8 more
doaj +1 more source

pbpk
physiologically based biopharmaceutics modeling
virtual bioequivalence

ibuprofen
food effect
therapeutics

pharmacology
biorelevant dissolution