DoE- and PBBM-Driven Formulation Development of an Extended-Release Donepezil Tablet [PDF]
PharmaceuticalsBackground/Objectives: This study explores the integration of Design of Experiments (DoE) with Physiologically Based Biopharmaceutics Modeling (PBBM) to streamline the development of extended-release (XR) formulations.
Frederico Severino Martins +4 more
doaj +2 more sources
Development of Biopredictive Dissolution Method for Extended-Release Desvenlafaxine Tablets [PDF]
Pharmaceutics, 2023 This study aimed to develop a biopredictive dissolution method for desvenlafaxine ER tablets using design of experiments (DoE) and physiologically based biopharmaceutics modeling (PBBM) to address the challenge of developing generic drug products by ...
Gustavo Vaiano Carapeto +3 more
doaj +2 more sources
Integrating In Vitro BE Checker with In Silico Physiologically Based Biopharmaceutics Modeling to Predict the Pharmacokinetic Profiles of Oral Drug Products [PDF]
PharmaceuticsObjective: The objective of this study was to develop a Physiologically Based Biopharmaceutics Modeling (PBBM) framework that can predict PK profiles in humans based on data generated from the BE Checker.
Takuto Niino +6 more
doaj +2 more sources
In Vitro–In Silico Approach in the Development of Clopidogrel Solid Dispersion Formulations [PDF]
BioengineeringThe aim of this study was to investigate the influence of solid dispersion (SD) formulation factors on improvement of the bioavailability and pharmacokinetic profile of clopidogrel after peroral administration using an in vitro–in silico approach.
Ehlimana Osmanović Omerdić +4 more
doaj +2 more sources
Physiologically-Based Biopharmaceutics Modeling for Ibuprofen: Identifying Key Formulation Parameter and Virtual Bioequivalence Assessment [PDF]
PharmaceuticsBackground: Physiologically based pharmacokinetic (PBPK) modeling for biopharmaceutics applications (i.e., physiologically based biopharmaceutics modeling (PBBM)) enables mechanistic modeling from dissolution to absorption and disposition, facilitating ...
Javier Zarzoso-Foj +5 more
doaj +2 more sources
Bile micelle binding of structurally diverse ionized drug molecules [PDF]
ADMET and DMPKBackground and purpose: Predicting the food effect on oral drug absorption by physiologically based biopharmaceutical modelling (PBBM) remains challenging.
Mayu Konishi, Kiyohiko Sugano
doaj +2 more sources
Physiologically Based Pharmacokinetic and Physiologically Based Biopharmaceutic models research in Latin America: A regional level bibliometric analysis, 2011-2023 [PDF]
Brazilian Journal of Pharmaceutical SciencesThe landscape of scientific research in Latin America (LA), particularly in the realms of the Physiologically Based Pharmacokinetic (PBPK) and Physiologically Based Biopharmaceutic models (PBPM), is a mosaic of varied contributions, collaborations, and ...
Marx Ribeiro +5 more
doaj +4 more sources
A text mining study on the utility of physiologically based pharmacokinetic/biopharmaceutics modeling (PBPK/PBBM) in formulation development [PDF]
Macedonian Pharmaceutical Bulletin, 2023 Physiologically based pharmacokinetic (PBPK) modeling is an evolving tool that has a profound impact on drug discovery and formulation development processes.
Cvijić, Sandra +3 more
core +3 more sources
In Vivo Predictive Dissolution and Biopharmaceutic-Based In Silico Model to Explain Bioequivalence Results of Valsartan, a Biopharmaceutics Classification System Class IV Drug [PDF]
PharmaceuticsThe purpose of this study was to predict the in vivo bioequivalence (BE) outcome of valsartan (VALS, BCS class IV) from three oral-fixed combination products with hydrochlorothiazide (HCTZ, BCS class III) (Co-Diovan® Forte as reference and two generic ...
Isabel Gonzalez-Alvarez +6 more
doaj +2 more sources
Using molecularly dissolved drug concentrations in PBBMs improves the prediction of oral absorption from supersaturating formulations [PDF]
European Journal of Pharmaceutical SciencesPredicting the absorption of drugs from enabling formulations is still challenging due to the limited capabilities of standard physiologically based biopharmaceutics models (PBBMs) to capture complex absorption processes.
Bauer-Brandl, Annette +4 more
core +3 more sources