Results 71 to 80 of about 455 (133)

Finger Vein Recognition based on Personalized Discriminative Bit Map [PDF]

, 2014
Finger vein recognition is a promising biometric recognition due to its some advantages. For a finger vein recognition system, feature extraction is a critical step for the final recognition.
Yin, Yilong, Yang, Gongping, Li, Xuzhou, Xi, Xiaoming   +3 more
core   +1 more source

A Combined Modeling Approach to Predict the Effect of Gastric Emptying Delay on the Pharmacokinetics of Small Molecules

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 12, Page 2026-2039, December 2025.
ABSTRACT Dulaglutide, a long‐acting glucagon‐like peptide‐1 (GLP‐1) receptor agonist, is approved for improving glycemic control and reducing cardiovascular risks in patients with type 2 diabetes mellitus (T2DM). This research investigates the effect of dulaglutide on gastric emptying and its impact on the pharmacokinetics (PK) of orally administered ...
Maria M. Posada, Karen B. Schneck, Bridget L. Morse, Luc R. A. Rougee, Lai San Tham, Jessica F. Rehmel, Brian Thompson, Stephen D. Stamatis, Stephen D. Hall, Gemma L. Dickinson   +9 more
wiley   +1 more source

Evaluation of alveolar ridge preservation in sockets with buccal dehiscence defects using two types of xenogeneic biomaterials: An in vivo experimental study

, 2023
Objectives: Alveolar ridge preservation (ARP) has been extensively investigated in various preclinical and clinical studies, yielding favorable results.
Oh, Seunghan, Sungtae Kim, Lee, Jung-Tae, Young‐Dan Cho, Cho, Young-Dan, Hee‐seung Han, Seunghan Oh, Kim, Sungtae, Jung‐Tae Lee, Han, Hee-seung   +9 more
core   +1 more source

An Open‐Source Framework for Virtual Bioequivalence Modeling and Clinical Trial Design

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 12, Page 1932-1948, December 2025.
ABSTRACT To establish bioequivalence (BE) of a generic test formulation with respect to a reference listed drug, it is necessary to demonstrate a comparable rate and extent to which active ingredients reach the site of action. To decrease unnecessary human testing and simulate scenarios involving specific populations or challenges with recruitment or ...
Abdullah Hamadeh, Moriah Pellowe, Pierre Chelle, Cindy Hoi Ting Yeung, Julian Otalvaro, Walter Yamada, Jay Bartroff, Alona Kryshchenko, André Dallmann, Juri Solodenko, Jörg Lippert, Eleftheria Tsakalozou, Michael Neely, Andrea Edginton   +13 more
wiley   +1 more source

Modelo biofarmacêutico baseado em fisiologia (PBBM) aplicado ao desenvolvimento de formulações de liberação prolongada contendo cloridrato de ciclobenzaprina

, 2023
Modelos biofarmacêuticos baseados em fisiologia - PBBM sofreram grandes avanços nas últimas décadas. Emergindo como ferramentas fundamentais no desenvolvimento de formulações orais, por sua capacidade de simulação e predição de parâmetros ...
Santos, Everton Miranda dos [UNIFESP]
core  

Best Practices in the Development and Validation of Physiologically Based Biopharmaceutics Modeling. A Workshop Summary Report

, 2022
S.584-593This workshop report summarizes the proceedings of Day 2 of a three-day workshop on ""Current State and Future Expectations of Translational Modeling Strategies to Support Drug Product Development, Manufacturing Changes and Controls"".
Wagner, C., Butler, J., Raines, K., Kakhi, M., Tsakalozou, E., Mullin, J., Pepin, X., Kesisoglou, F., Suarez-Sharp, S., Zhao, Y., Dressman, J., Flanagan, T., Pathak, S.M., Dallmann, A., Riedmaier, A.E., Patel, N., Parrott, N., Good, D., Li, M., Mitra, A.   +19 more
core   +1 more source

Using molecularly dissolved drug concentrations in PBBMs improves the prediction of oral absorption from supersaturating formulations

European Journal of Pharmaceutical Sciences
Predicting the absorption of drugs from enabling formulations is still challenging due to the limited capabilities of standard physiologically based biopharmaceutics models (PBBMs) to capture complex absorption processes. Amongst others, it is often assumed that both, molecularly and apparently dissolved drug in the gastrointestinal lumen are prone to ...
Holzem, Florentin Lukas, Petrig Schaffland, Jeannine, Brandl, Martin, Bauer-Brandl, Annette, Stillhart, Cordula   +4 more
openaire   +2 more sources

Application of the Gastrointestinal Simulator (GIS) Coupled with In Silico Modeling to Measure the Impact of Coca-Cola^® on the Luminal and Systemic Behavior of Loratadine (BCS Class 2b)

Pharmaceutics, 2020
In the present work, we explored if Coca-Cola® had a beneficial impact on the systemic outcome of the weakly basic drug loratadine (Wal-itin®, immediate-release formulation, 10 mg, generic drug product).
Bart Hens, Marival Bermejo, Patrick Augustijns, Rodrigo Cristofoletti, Gregory E. Amidon, Gordon L. Amidon   +5 more
doaj   +1 more source

A physiologically based biopharmaceutical analysis of zolpidem

, 2021
Computational oral absorption models, in particular PBBM models, provide a powerful tool for researchers and pharmaceutical scientists in drug discovery and formulation development, as they mimic and can describe the physiologically processes relevant to
Paraiso, Rafael Leal Monteiro
core   +1 more source

Current State and Future Expectations of Translational Modeling Strategies to Support Drug Product Development, Manufacturing Changes and Controls: A Workshop Summary Report

, 2022
S.555-566The implementation of clinically relevant drug product specifications (CRDPS) depends on establishing a link between in vitro performance and in vivo exposure.
Babiskin, A., Delvadia, P., Kolhatkar, V., Pepin, X.J.H., Parrott, N., Suarez-Sharp, S., Zhang, X., Dressman, J., Mitra, A.   +8 more
core   +1 more source