Physiologically‐Based Pharmacokinetic Modeling to Support Pediatric Clinical Development: An IQ Working Group Perspective on the Current Status and Challenges [PDF]
CPT: Pharmacometrics & Systems PharmacologyPediatric extrapolation strategies issued by health authorities have streamlined pediatric drug development and reduced the unnecessary burden of conducting pediatric clinical studies. In line with these strategies, physiologically based pharmacokinetic (
James W. T. Yates +26 more
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Integrating Population Approaches With Physiologically Based Pharmacokinetic Models: A Novel Framework for Parameter Estimation [PDF]
CPT: Pharmacometrics & Systems PharmacologyPhysiologically Based Pharmacokinetic (PBPK) modeling is a powerful tool in drug development that integrates drug‐specific information with physiological parameters to predict drug concentrations.
Donato Teutonico +3 more
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Applications of PBPK Modeling to Estimate Drug Metabolism and Related ADME Processes in Specific Populations [PDF]
PharmaceuticsBackground: Physiologically based pharmacokinetic (PBPK) models utilize computer-based simulations to predict the pharmacokinetics of drugs. By using mathematical modeling techniques consisting of differential equations to simulate blood flow, tissue ...
Pavani Gonnabathula +4 more
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Current Approaches and Techniques in Physiologically Based Pharmacokinetic (PBPK) Modelling of Nanomaterials [PDF]
Nanomaterials, 2020 There have been efforts to develop physiologically based pharmacokinetic (PBPK) models for nanomaterials (NMs). Since NMs have quite different kinetic behaviors, the applicability of the approaches and techniques that are utilized in current PBPK models ...
Wells Utembe +4 more
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Frontiers in ToxicologyIntroductionWe previously developed a PBPK model template that consists of a single model “superstructure” with equations and logic found in many physiologically based pharmacokinetic (PBPK) models.
Amanda S. Bernstein +3 more
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Predictive modelling and simulation for taming the chance and luck in biologics drug discovery [PDF]
Proceedings of the Estonian Academy of Sciences, 2023 Three Pillars of Survival paradigm in the pharmaceutical drug discovery stipulates that a drug candidate is more likely to reach Phase III if it meets the following criteria: 1) it reaches the required tissue compartment, 2) engages the desired target, 3)
Armin Sepp
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Comparative Analysis of Isavuconazole DDIs With Other Azole Antifungal Drugs and PBPK Model-Informed Dosing Recommendations for Anticancer Drugs. [PDF]
CPT Pharmacometrics Syst PharmacolGoosen TC +6 more
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CPT: Pharmacometrics & Systems Pharmacology, 2022 The phase distribution model, proposed by Atkinson and Begg in 1990, has been widely used for predicting breastmilk‐to‐plasma drug concentration ratio. However, misrepresentations of the equations have been noted in recent publications.
Mian Zhang +5 more
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The emerging role of physiologically-based pharmacokinetic/biopharmaceutics modeling in formulation development [PDF]
Arhiv za farmaciju, 2021 Computer-based (in silico) modeling & simulation tools have been embraced in different fields of pharmaceutics for a variety of applications. Among these, physiologically-based pharmacokinetic/biopharmaceutics modeling (PBPK/PBBM) emerged as a ...
Cvijić Sandra +3 more
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Review of the pharmacokinetics of nanodrugs
Nanotechnology Reviews, 2023 Nanodrug delivery systems (NDDSs) are a hotspot of new drug delivery systems with great development potential. They provide new approaches to fighting against diseases.
Shao Xiaotong +4 more
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