Results 121 to 130 of about 14,363 (238)

Integrated PBPK-EO modeling of osimertinib to predict plasma concentrations and intracranial EGFR engagement in patients with brain metastases

Scientific Reports
The purpose of this study was to develop and validate a physiologically based pharmacokinetic (PBPK) model combined with an EGFR occupancy (EO) model for osimertinib (OSI) to predict plasma trough concentration (Ctrough) and the intracranial time-course ...
Feng Liang, Yimei Zhang, Qian Xue, Xiaoling Zhang   +3 more
doaj   +1 more source

Analysis of Regulatory Inhalation Unit Risk Estimates for Cobalt: Comparison to Epidemiological Data

Risk Analysis, Volume 46, Issue 4, April 2026.
ABSTRACT Several cancer potency estimates have been proposed by regulatory agencies to characterize the dose response of cobalt and/or cobalt compounds. The objective of this research is to investigate whether these proposed cancer potency estimates for certain cobalt substances align with the available epidemiology literature.
Lynne P. Marshall, Vanessa Viegas, Andrew Maier, Gary Marsh, Marisa L. Kreider   +4 more
wiley   +1 more source

Prediction of Monoclonal Antibody Pharmacokinetics in Pediatric Populations Using PBPK Modeling and Simulation

Pharmaceutics
Background: Accurately determining pediatric dosing is essential prior to initiating clinical trials or administering medications in routine clinical settings. In children, ethical considerations demand careful evaluation of both safety and effectiveness.
Chiara Zunino, Virginie Gualano, Haiying Zhou, Viera Lukacova, Maxime Le Merdy   +4 more
doaj   +1 more source

Non-equilibrium entangled steady state of two independent two-level systems

, 2011
We determine and study the steady state of two independent two-level systems weakly coupled to a stationary non-equilibrium environment. Whereas this bipartite state is necessarily uncorrelated if the splitting energies of the two-level systems are ...
A. Peres, A.J. Leggett, D. Braun, D.P.S. McCutcheon, F. Benatti, F. Kheirandish, G. Vidal, J.S. Bell, K. Zyczkowski, L. Hartmann, L. Jacóbczyk, L. Jakóbczyk, L.D. Contreras-Pulido, M. Horodecki, M.B. Plenio, M.O. Terra Cunha, P. Zanardi, P.J. Dodd, R.F. Werner, R.H. Lehmberg, S. Camalet, S. Camalet, T. Yu, T. Yu, Ö. Çakir   +24 more
core   +2 more sources

Physiologically based pharmacokinetic model combined with a clinical lactation study to determine doravirine concentrations in human breastmilk

British Journal of Clinical Pharmacology, Volume 92, Issue 3, Page 952-959, March 2026.
Aims To determine breastmilk concentrations of doravirine via PBPK modelling in combination with a clinical lactation study. As women living with HIV are not able to cease antiretroviral therapy during lactation, it is necessary to establish drug transfer into breastmilk to determine exposure of the infant to antiretroviral drugs and potential risk of ...
Lena van der Wekken‐Pas, David Burger, Rick Greupink, Angela Colbers   +3 more
wiley   +1 more source

Absolute Bioavailability and Absorption, Distribution, Metabolism, and Excretion of [14C]Xevinapant, a Potent, Oral, Small‐Molecule IAP Inhibitor

Clinical Pharmacology in Drug Development, Volume 15, Issue 3, March 2026.
Abstract This Phase 1, open‐label, 2‐part, single‐dose study aimed to investigate the pharmacokinetics, metabolism, and excretion of xevinapant, a small molecule inhibitor of apoptosis proteins (IAPs), in healthy male subjects. Part 1 focused on determining the mass balance recovery, pharmacokinetics, and metabolic profile of [14C]xevinapant following ...
Annick Menetrey, Valérie Nicolas‐Metral, Marie‐Claude Roubaudi‐Fraschini, Tri Tat, Yuan Zhao, Yulia Vugmeyster, Karthik Venkatakrishnan, Felix Rohdich, Holger Scheible   +8 more
wiley   +1 more source

Exploring inter-ethnic and inter-patient variability and optimal dosing of osimertinib: a physiologically based pharmacokinetic modeling approach

Frontiers in Pharmacology
Purpose: This study aimed to develop and validate a physiologically based pharmacokinetic (PBPK) model for osimertinib (OSI) to predict plasma trough concentration (Ctrough) and pulmonary EGFRm+ (T790M and L858R mutants) inhibition in Caucasian, Japanese,
Feng Liang, Yimei Zhang, Qian Xue, Na Yao   +3 more
doaj   +1 more source

Population Pharmacokinetic Modeling Practice of Time‐Varying Clearance: Insights from a First‐in‐Human Study Case

The Journal of Clinical Pharmacology, Volume 66, Issue 3, March 2026.
Abstract Accurate characterization of time‐varying clearance (CL) is critical during early drug development, as it informs clinical study design and dosing strategies for future trials. However, detecting and modeling time‐varying clearance is challenging due to limited data availability in early clinical development.
Yongjun Hu, Lan Gao, Ronald Kong
wiley   +1 more source

A tutorial on physiologically based pharmacokinetic approaches in lactation research

CPT: Pharmacometrics & Systems Pharmacology
In breastfeeding mothers, managing medical conditions presents unique challenges, particularly concerning medication use and breastfeeding practices.
Amita Pansari, Xian Pan, Lisa M. Almond, Karen Rowland‐Yeo   +3 more
doaj   +1 more source

Machine Learning for Predictive Modeling in Nanomedicine‐Based Cancer Drug Delivery

Med Research, Volume 2, Issue 1, Page 130-156, March 2026.
The integration of AI/ML into nanomedicine offers a transformative approach to therapeutic design and optimization. Unlike conventional empirical methods, AI/ML models (such as classification, regression, and neural networks) enable the analysis of complex clinical and formulation datasets to predict optimal nanoparticle characteristics and therapeutic
Rohan Chand Sahu, Sanchit Arora, Dinesh Kumar, Ashish Kumar Agrawal   +3 more
wiley   +1 more source