Results 161 to 170 of about 16,022 (277)

From Radiocopper to Cold Copper: Mechanistic Modeling and Simulation to Define Clinical Response Criteria and Biomarkers for VTX‐801 in Wilson Disease

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 1, January 2026.
ABSTRACT We developed a comprehensive, mechanistic model of human copper metabolism to support biomarker qualification for VTX‐801, an adeno‐associated vector‐based gene therapy which is being developed to restore the mutated ATP7B copper transporter gene in Wilson disease (WD). The model integrates physiological copper kinetics with pathophysiological
Andreas Lindauer, Bernard Benichou, Gloria González Aseguinolaza, Jean‐Philippe Combal   +3 more
wiley   +1 more source

Global Sensitivity Analysis of a Physiologically-based Pharmacokinetic (PBPK) Model of Bromochloromethane [PDF]

, 2020
Sawyer, Colton
core   +1 more source

1086. A Whole-Body Quantitative System Pharmacology Physiologically-Based Pharmacokinetic (QSP/PBPK) Model that a priori Predicts Intramuscular (IM) Pharmacokinetics of ADG20: an Extended Half-life Monoclonal Antibody Being Developed for the Treatment and Prevention of Coronavirus Disease (COVID-19) [PDF]

, 2021
Scott A. Van Wart, Evan Tarbell, Donald E. Mager, Dhaval K. Shah, Lynn Connolly, Paul G. Ambrose   +5 more
openalex   +1 more source

stormTB: A web-based simulator of a murine minimal-PBPK model for anti-tuberculosis treatments [PDF]

Roberto Visintainer, Anna Fochesato, Daniele Boaretti, Stefano Giampiccolo, Shayne Watson, Micha Levi, Federico Reali, Luca Marchetti   +7 more
openalex   +1 more source

A Comprehensive Physiologically Based Pharmacokinetic (PBPK) Model for Nicotine in Humans Including Deposition and Diffusion in the Buccal and Respiratory Tissues from Using Different Nicotine-Containing Products with Different Routes of Exposure [PDF]

, 2021
Ali A. Rostami, Jerry L. Campbell, Yezdi B. Pithawalla, Hamideh Pourhashem, Raheema Muhammad-Kah, Mohamadi Sarkar, Jianmin Liu, Willie McKinney, Robinan Gentry, Maria Gogova   +9 more
openalex   +1 more source

Issue Information

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
wiley   +2 more sources

PBPK modeling/Monte Carlo simulation of methylene chloride kinetic changes in mice in relation to age and acute, subchronic, and chronic inhalation exposure.

, 1996
Russell S. Thomas, R.S.H. Yang, D. Morgan, Michael P. Moorman, Hamid Kermani, Richard A. Sloane, Robert W. O’Connor, Bernard Adkins, Michael L. Gargas, Melvin E. Andersen   +9 more
openalex   +2 more sources

Formulation development, characterization, and mechanistic PBPK modeling of metoclopramide loaded halloysite nanotube (HNT) based drug-in-adhesive type transdermal drug delivery system [PDF]

Monica Parkash, Muhammad Harris Shoaib, Muhammad Sikandar, Rabia Ismail Yousuf, Muhammad Talha Saleem, Farrukh Rafiq Ahmed, Fahad Siddiqui   +6 more
openalex   +1 more source

PBPK modeling of ivermectin—Considerations for the purpose of developing alternative routes to optimize its safety profile [PDF]

, 2023
Karen Rowland Yeo, David Wesche
openalex   +1 more source

Analysis of Current Industry Practices for Informing Dosing Recommendation for Patients With Renal Impairment

Clinical and Translational Science, Volume 19, Issue 1, January 2026.
ABSTRACT Recent updates in clinical guidelines and health authority guidance documents have aimed to standardize best practices for assessing renal function; however, it remains unclear whether the pharmaceutical industry has fully adopted these recommendations.
Noah Christopher Frazier, Islam Younis, Ashish Sharma   +2 more
wiley   +1 more source