CPT: Pharmacometrics & Systems Pharmacology, 2023 The pharmacokinetics (PKs) and safety of medications in particular groups can be predicted using the physiologically‐based pharmacokinetic (PBPK) model.
Xu Zhou +5 more
doaj +1 more source
Normal Numbers and the Borel Hierarchy [PDF]
, 2013 We show that the set of absolutely normal numbers is $\mathbf \Pi^0_3$-complete in the Borel hierarchy of subsets of real numbers.
Becher, Verónica +2 more
core +3 more sources
Comparison of Subjective Responses to Oral and Intravenous Alcohol Administration under Similar Systemic Exposures [PDF]
, 2019 Objective To test whether an individual's subjective responses to alcohol are similar when the breath alcohol concentration (BrAC) trajectory resulting from oral administration is matched by intravenous administration.
Boes, Julian +6 more
core +1 more source
Model-Informed Precision Dosing of Antibiotics in Osteoarticular Infections
Infection and Drug Resistance, 2022 Lingling Liu,1 Jin Wang,1 Huan Zhang,1 Mengli Chen,2 Yun Cai1 1Center of Medicine Clinical Research, Department of Pharmacy, Medical Supplies Center, PLA General Hospital, Beijing, People’s Republic of China; 2Department of Pharmacy, Medical Supplies ...
Liu L, Wang J, Zhang H, Chen M, Cai Y
doaj
Virtual bioequivalence for achlorhydric subjects: The use of PBPK modelling to assess the formulation-dependent effect of achlorhydria [PDF]
, 2017 Majority of bioequivalence studies are conducted in healthy volunteers. It has been argued that bioequivalence may not necessarily hold true in relevant patient populations due to a variety of reasons which affect one formulation more than the other for ...
Darwich Adam S. +4 more
core +1 more source
Translocation of gold nanoparticles across the lung epithelial tissue barrier: Combining in vitro and in silico methods to substitute in vivo experiments [PDF]
, 2015 The lung epithelial tissue barrier represents the main portal for entry of inhaled nanoparticles (NPs) into the systemic circulation. Thus great efforts are currently being made to determine adverse health effects associated with inhalation of NPs ...
Bachler, Gerald +7 more
core +1 more source
An Overview of Physiologically-Based Pharmacokinetic Models for Forensic Science
Toxics, 2023 A physiologically-based pharmacokinetic (PBPK) model represents the structural components of the body with physiologically relevant compartments connected via blood flow rates described by mathematical equations to determine drug disposition. PBPK models
Kiara Fairman +6 more
doaj +1 more source
Integration of Genome Scale Metabolic Networks and gene regulation of metabolic enzymes with Physiologically Based Pharmacokinetics [PDF]
, 2017 The scope of Physiologically Based Pharmacokinetic (PBPK) modelling can be expanded by assimilation of the mechanistic models of intracellular processes from Systems Biology field.
Al Olama +51 more
core +2 more sources
Simulated rat intestinal fluid improves oral exposure prediction for poorly soluble compounds over a wide dose range [PDF]
, 2016 Solubility can be the absorption limiting factor for drug candidates and is therefore a very important input parameter for oral exposure prediction of compounds with limited solubility.
Bernard Faller +3 more
core +3 more sources
Tingkat Parasitasi Parasitoid Telur Pbpk pada Pertanaman Padi dengan Beberapa Ketinggian Tempat Berbeda [PDF]
, 2016 Rice is the staple food of Indonesia's population. Various problems occur in an effort to increase production and productivity. One problem is the attack of yellow rice stem borer (PBPK) which may result in yield losses up to 90%.
Resiani, N. M. (Ni)
core +1 more source