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Physiologically Based Pharmacokinetic (PBPK) Modeling of Pharmaceutical Nanoparticles
The AAPS Journal, 2016With the great interests in the discovery and development of drug products containing nanoparticles, there is a great demand of quantitative tools for assessing quality, safety, and efficacy of these products. Physiologically based pharmacokinetic (PBPK) modeling and simulation approaches provide excellent tools for describing and predicting in vivo ...
Min, Li +3 more
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A PBPK model for midazolam in four avian species
Journal of Veterinary Pharmacology and Therapeutics, 2009A physiologically based pharmacokinetic (PBPK) model was developed for midazolam in the chicken and extended to three other species. Physiological parameters included organ weights obtained from 10 birds of each species and blood flows obtained from the literature. Partition coefficients for midazolam in tissues vs.
K A, Cortright +2 more
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Assessing interindividual variability by Bayesian-PBPK modeling
Drug Discovery Today: Disease Models, 2016The description of interindividual variability and the ADME-related sources of such variability (ADME: absorption, distribution, metabolization, excretion) is an essential element in clinical drug development to identify potentially relevant subgroups of non-responders or high-risk patients.
Markus Krauss, Andreas Schuppert
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Chlorpyrifos PBPK/PD model for multiple routes of exposure
Xenobiotica, 20141. Chlorpyrifos (CPF) is an important pesticide used to control crop insects. Human Exposures to CPF will occur primarily through oral exposure to residues on foods. A physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) model has been developed that describes the relationship between oral, dermal and inhalation doses of CPF and key events ...
Torka S, Poet +3 more
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Probabilistic dose–response modeling: Case study using dichloromethane PBPK model results
Regulatory Toxicology and Pharmacology, 2007A revised assessment of dichloromethane (DCM) has recently been reported that examines the influence of human genetic polymorphisms on cancer risks using deterministic PBPK and dose-response modeling in the mouse combined with probabilistic PBPK modeling in humans.
Dale J, Marino, Thomas B, Starr
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Rapid PBPK modeling with the httk model
2018A Course on Physiologically Based Pharmacokinetic (PBPK) Modeling Given at ScitoVation Nov ...
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Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies
Ca-A Cancer Journal for Clinicians, 2022Paolo Tarantino +2 more
exaly
Sensitivity analysis of PBPK models
Toxicology Letters, 2010G. Loizou, K. Mcnally
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