Results 91 to 100 of about 17,065,304 (244)

Resveratrol attenuates the CoCl2-induced hypoxia damage by regulation of lysine β-hydroxybutyrylation in PC12 cells

BMC Neurology
Background Stroke is a cerebrovascular disease that is the main cause of death and disability worldwide. Hypoxia is a major factor that causes neuronal damage and even cellular death.
Yamei Wang, Jian Zhao, Liang Sun, Dingding Xu, Xiaoming Wei, Jia Li, Zihan Mo, Nian Xia, Junge Zhou, Yuan Yao, Qiao Hu, Qingqing Zhou   +11 more
doaj   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

Apocynin Attenuates Cobalt Chloride-Induced Pheochromocytoma Cell Apoptosis by Inhibiting P38-MAPK/Caspase-3 Pathway

Cellular Physiology and Biochemistry, 2018
Background/Aims: Apocynin, a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor, has been identified as a potential neuroprotectant.
Jie  Liu, Yuzhang Zhu, Shipiao Chen, Bin Shen, Fang Yu, Yi Zhang, Ruilin Shen   +6 more
doaj   +1 more source

Dopamine: The Essential Bridge Mediating Obstructive Sleep Apnea and Hippocampus‐Dependent Learning and Memory Impairments

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Obstructive sleep apnea is a clinical syndrome that triggers a series of pathophysiologic changes, including disturbed sleep architecture, chronic intermittent hypoxia and hypercapnia, and ultimately severe cognitive dysfunction. The hippocampus plays a key role in various cognitive processes such as learning and memory.
Rui Fan, Tao Li, Yan Yan
wiley   +1 more source

A Novel Antioxidant Peptide Cath‐Np Derived from Nanorana parkeri Attenuates UVB‐Induced Skin Photodamage in Mice

Integrative Zoology, EarlyView.
Schematic representation of Cath‐Np as an antioxidant suppressing acute skin damage caused by ultraviolet B (UVB) radiation in mice. Cath‐Np inhibits the activation of p53 and mitogen‐activated protein kinase pathways while it activates the Nrf2 pathway by its strong antioxidant effects, and accordingly suppresses the expression of inflammatory factors
Hang Liao, Xiaoxiao Shen, Jinwei Chai, Kai wang, Jiena Wu, Jianxi Yang, Ming Chen, Guoxiang Mo, Xueqing Xu   +8 more
wiley   +1 more source

Naringin ameliorates H2O2-induced oxidative damage in cells and prolongs the lifespan of female Drosophila melanogaster via the insulin signaling pathway

Food Science and Human Wellness
Naringin exists in a wide range of Chinese herbal medicine and has proven to possess several pharmacological properties. In this study, PC12, HepG2 cells, and female Drosophila melanogaster were used to investigate the antioxidative and anti-aging ...
Xiaomei Du, Kexin Wang, Xiaoyan Sang, Xiangxing Meng, Jiao Xie, Tianxin Wang, Xiaozhi Liu, Qun Huang, Nan Zhang, Hao Wang   +9 more
doaj   +1 more source

Real-time electrochemical recording of dopamine release under optogenetic stimulation.

PLoS ONE, 2014
Dopaminergic PC12 cells can synthesize and release dopamine, providing a good cellular model for investigating dopamine regulation. Optogenetic stimulation of channelrhodopsin-2 provides high spatial and temporal precision for selective stimulation as a ...
Wen-Tai Chiu, Che-Ming Lin, Tien-Chun Tsai, Chun-Wei Wu, Ching-Lin Tsai, Sheng-Hsiang Lin, Jia-Jin Jason Chen   +6 more
doaj   +1 more source

Characterization of the cell membrane-associated products of the Neuregulin 4 gene [PDF]

, 2008
The NRG4 gene is a member of a family of four genes which encode a class of epidermal growth factors. This gene has been reported to express a protein designated here as NRG4A1.
Hayes, Nandini V. L., Gullick, William J., Baines, Anthony J., Newsam, Ray J.   +3 more
core   +1 more source

New biosensors and transgenic mice for multiplex cGMP imaging

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters, Martin Thunemann, Barbara Birk, Susanne Feil, Viacheslav O. Nikolaev, Moritz Lehners, Robert Feil   +6 more
wiley   +1 more source

Structure Analysis of O-Glycans from Edible Bird's Nest and Its Antioxidant Effects against H2O2-induced Oxidative Damage in PC12 Cells

Shipin gongye ke-ji
Objective: To elucidate the specific structure of O-glycans of edible bird's nests and their antioxidant protective effects on neuronal cells. Methods: O-glycans from the mucin of edible bird's nests were released using a chemical method, and their ...
Ya LIU, VOGLMEIR Josef, Li LIU
doaj   +1 more source