Results 61 to 70 of about 88,809 (304)

Endocannabinoid receptor blockade increases hepatocyte growth factor and reduces insulin levels in obese women with polycystic ovary syndrome [PDF]

, 2016
There is evidence from animal and in-vitro studies that activation of the endocannabinoid system (EC) through cannabinoid receptor 1 (CB-1) is associated with liver injury, inflammation and hepatocellular carcinoma.1 Data suggests endogenous cannabinoids
Ahmed, Lina, Atkin, Stephen L., Coady, Anne-Marie, Dakroury, Youssra, Elshewehy, Abeer M. M., Kilpatrick, Eric S., Sathyapalan, Thozhukat   +6 more
core   +2 more sources

Identification of A p300–SP1–BRD4 Transcriptional Axis as a Key Driver of AR Hyperactivation in Polycystic Ovarian Syndrome

Advanced Science, EarlyView.
This study reveals a pivotal epigenetic regulatory role for the histone acetyltransferase p300, demonstrating that its acetylation of histone 3 at lysine 18 and 27 (H3K18ac and H3K27ac), alongside the formation of the p300/BRD4/SP1 complex, drives AR activation and ovarian fibrosis in PCOS.
Zhengquan Zhu, Yihan Wang, Haiyun Chen, Xinye Yu, Tingyu Wang, Yajing Weng, Meihong Guo, Ying Huang, Gaojian Tao, Wangsen Cao, Yong Wang, Daojuan Wang   +11 more
wiley   +1 more source

Association of Circulating Spexin Levels with Metabolic and Hormonal Disturbances in Polycystic Ovary Syndrome Women and Normal Controls

Annals of Abbasi Shaheed Hospital and Karachi Medical & Dental College, 2023
Objective: To evaluate and compare theserum Spexin levels in women with and without polycystic ovary syndrome (PCOS) and to find if there is any association of Spexin levels with metabolic and hormonal parameters among PCOS women.
Maliha Shameem, Taseer Ahmed Khan, Kausar Abbas Saldera, Hina Rashid, UfaqueBatool K. Samo   +4 more
doaj  

Polycystic ovarian syndrome leading to ovarian torsion in a 19-year-old

Medical Journal of Dr. D.Y. Patil Vidyapeeth, 2018
Ovarian torsion (OT) is the fifth most common gynecological emergency with a reported prevalence of 2.5%–7.4%. A 19-year-old unmarried girl, known the case of the polycystic ovarian syndrome (PCOS) was referred with sudden onset left-sided lower ...
Savita Rani Singhal, Kriti Agarwal, Krishna Dahiya, Reetu Hooda   +3 more
doaj   +1 more source

A double-edge sword: the role of D-chiro-inositol in oocyte and embryo quality [PDF]

International Journal of Medical Device and Adjuvant Treatments, 2019
D-chiro-inositol is one of the nine stereoisomers of inositol, a water-soluble cyclic carbohydrate with six hydroxyl groups. Inositol has an essential function in the activation of crucial enzymes in glucose metabolism. In fact, D-chiro-inositol shortage
M. Minini, G. Monastra, S. Dinicola
doaj   +1 more source

Efficacy of very low-calorie ketogenic diet with the Pronokal® method in obese women with polycystic ovary syndrome: a 16-week randomized controlled trial

Endocrine Connections, 2023
Objective: The aim of this study is to assess the efficacy of a very low-calorie ketogenic diet (VLCKD) method vs a Mediterranean low-calorie diet (LCD) in obese polycystic ovary syndrome (PCOS) women of a reproductive age.
Srdjan Pandurevic, Ilaria Mancini, Dimitri Mitselman, Matteo Magagnoli, Rita Teglia, Roberta Fazzeri, Paola Dionese, Carolina Cecchetti, Massimiliamo Caprio, Costanzo Moretti, Justyna Sicinska, Alessandro Agostini, Domenica Gazineo, Lea Godino, Ignacio Sajoux, Flaminia Fanelli, Cristina M Meriggiola, Uberto Pagotto, Alessandra Gambineri   +18 more
doaj   +1 more source

IGFBP5 Restores Endometrial Receptivity and Rescues Implantation Failure in Polycystic Ovary Syndrome

Advanced Science, EarlyView.
Impaired endometrial receptivity contributes to the poor pregnancy outcomes in women with PCOS. The authors found that decreased endometrial IL‐22 levels and disrupted STAT3‐IGFBP5 signaling pathway contributed to impaired endometrial receptivity. Supplementation with IL‐22 or IGFBP5 exerts a protective effect on implantation failure in PCOS‐like mice,
Baoying Liao, Chuyu Yun, Hongying Shan, Yuqian Wang, Xiunan Chen, Weisi Lian, Tianliu Peng, Min Zhao, Xunsi Qin, Kailun Hu, Ping Zhou, Yue Wang, Yanli Pang, Rong Li   +13 more
wiley   +1 more source

Environmental exposure to selected non-persistent endocrine disrupting chemicals and polycystic ovary syndrome: a systematic review

International Journal of Occupational Medicine and Environmental Health
Polycystic ovary syndrome (PCOS) is an endocrine disorder manifesting with symptoms such as irregular menstrual cycles, hyperandrogenism, and/or polycystic ovaries.
Magdalena Ozga, Joanna Jurewicz
doaj   +1 more source

Real‐Time and High‐Resolution NIR‐II‐L Imaging of Netrin‐1‐Mediated Neurovascular Coupling Driven by Dose‐Dependent Electroacupuncture

Advanced Science, EarlyView.
Disrupted neurovascular coupling contributes to ovarian dysfunction in polycystic ovary syndrome. Using near‑infrared II long‑wavelength imaging, this study visualizes how electroacupuncture dynamically regulates ovarian blood vessels in vivo. Immediate and cumulative stimulation elicit distinct vascular responses via a Netrin‐1 dependent mechanism ...
Yicong Wang, Zi‐Han Chen, Jiajia Li, Wei Hu, Ying Cao, Yu Wang, Xiaoyu Tong, Wenhan Lu, Yuze Yang, Yuehao Wang, Yan Xiao, Wenhao Gao, Yuning Chen, Yuyan Hou, Fan Zhang, Yi Feng   +15 more
wiley   +1 more source

PCOS in adolescents

Best Practice & Research Clinical Obstetrics & Gynaecology, 2010
Polycystic ovary syndrome (PCOS), a heterogeneous syndrome of unknown aetiology, is the leading cause of anovulation, hirsutism and infertility in women. This multifactorial syndrome emerges at puberty and has cardiovascular and metabolic sequelae through menopause.
openaire   +3 more sources