Results 111 to 120 of about 3,764,452 (295)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Influence of Container Volume and Cuttings Size on the Growth Parameters of Seedlings with a Closed Root System of Two Poplar Genotypes in the Voronezh Region

International Journal of Plant Biology
This study examined the bioproductivity of two poplar genotypes propagated by single-tree stem cuttings. The experiment compared variants using cuttings of different lengths (10–22 cm) and containers with volumes from 1 to 3 L. It was found that the best
Peter Evlakov, Alexey Tseplyaev, Anna Popova, Vladimir Zapletin, Vladlena Ryzhkova, Lyudmila Repnikova, Konstantin Zhuzhukin   +6 more
doaj   +1 more source

Implementation of a National Reference Laboratory for Buruli Ulcer Disease in Togo [PDF]

, 2013
Background: In a previous study PCR analysis of clinical samples from suspected cases of Buruli ulcer disease (BUD) from Togo and external quality assurance (EQA) for local microscopy were conducted at an external reference laboratory in Germany.
Amekuse, Komi, Awoussi, Koffi Somenou, Badziklou, Kossi, Beissner, Marcus, Bidjada, Bawimodom, Bretzel, Gisela, Diefenhardt, Adolf, Halatoko, Wemboo Afiwa, Helfrich, Kerstin, Herbinger, Karl-Heinz, Huber, Kristina Lydia, Kere, Abiba Banla, Kobara, Basile, Loescher, Thomas, Maman, Issaka, Mengele, Carolin, Nitschke, Joerg, Piten, Ebekalisai, Prince-David, Mireille, Vogel, Felix, Wiedemann, Franz Xaver   +20 more
core   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

In-House RT-PCR Assay for Detection of Human Immunodeficiency Virus Type 1 Infection [PDF]

, 2009
Serologic assays are commonly used for screening (ELISA) and for confirmation (Western blot) of HIV-1 infection; however, both assays have potentially yielded the false-positive or false-negative results.
Bela, B. (Budiman), Fatmawati, N. N. (Ni), Ibrahim, F. (Fera), Parwati, K. T. (Ketut), Yasmon, A. (Andi)   +4 more
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

تجزیه‌وتحلیل نواحی ژنی E1A و E1B از آدنوویروس انسانی نوع 8 در بیماران مبتلا به کراتوکونژونکتیویت آدنوویروسی در شهر اهواز [PDF]

مجله دانشگاه علوم پزشکی سبزوار
زمینه و هدف: کراتوکونژونکتیویت اپیدمیک یک اختلال عفونی حاد چشمی است که اغلب با آدنوویروس انسانی نوع D8 (HAdV-D8) مرتبط می‌باشد.  E1Aو E1B آدنوویروسی به‌ترتیب از پروتئین‌های ضروری برای شروع عفونت آدنوویروسی و اتصال به p53 سلولی می‌باشند. این مطالعه با هدف
شهرام جلیلیان, ناهید امیدی, آذرخش آذران, منوچهر مکوندی, غلامرضا خاتمی نیا, کامبیز احمدی انگالی   +5 more
doaj   +1 more source

Examining peak height ratios in low template DNA samples with and without sampling using a single-tube extraction protocol [PDF]

, 2015
The developments of the polymerase chain reaction (PCR) and the short tandem repeat multiplex kits increased the ease and lowered the time and sample quantity required for deoxyribonucleic acid (DNA) typing compared to previous methods.
Nguyen, Thutrang Thi
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source