Results 51 to 60 of about 4,982,154 (391)
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, EarlyView.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source
CHREST tutorial: Simulations of human learning [PDF]
, 2004 CHREST (Chunk Hierarchy and REtrieval STructures) is a comprehensive, computational model of human learning and perception. It has been used to successfully simulate data in a variety of domains, including: the acquisition of syntactic categories, expert
Gobet, F, Lane, PCR
core +2 more sources
Chimeric 16S rRNA sequence formation and detection in Sanger and 454-pyrosequenced PCR amplicons.
Genome Research, 2011 Bacterial diversity among environmental samples is commonly assessed with PCR-amplified 16S rRNA gene (16S) sequences. Perceived diversity, however, can be influenced by sample preparation, primer selection, and formation of chimeric 16S amplification ...
B. Haas +14 more
semanticscholar +1 more source
Real-time RT-PCR in COVID-19 detection: issues affecting the results
Expert Review of Molecular Diagnostics, 2020 Due to the rapid spread and increasing number of coronavirus disease 19 (COVID-19) cases caused by a new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), rapid and accurat...
A. Tahamtan, A. Ardebili
semanticscholar +1 more source
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
Applied SciencesSalmonella enterica subsp. enterica serovar Typhimurium is an important foodborne pathogen, and poultry products are a major source of human infection.
Antonio Martínez-Murcia +6 more
doaj +1 more source
EPAM/CHREST tutorial: Fifty years of simulating human learning [PDF]
, 2009 Generating quantitative predictions for complex cognitive phenomena requires precise implementations of the underlying cognitive theory. This tutorial focuses on the EPAM/CHREST tradition, which has been providing significant models of human ...
Gobet, F, Lane, PCR
core
Journal of Medical Virology, 2020 In this study, we collected a total of 610 hospitalized patients from Wuhan between February 2, 2020, and February 17, 2020. We reported a potentially high false negative rate of real‐time reverse‐transcriptase polymerase chain reaction (RT‐PCR) testing ...
Yafang Li +6 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur +5 more
wiley +1 more source
An investigation into the effect of ageing on expert memory with CHREST [PDF]
, 2007 CHREST is a cognitive architecture that models human perception, learning, memory, and problem solving, and which has successfully simulated numerous human experimental data on chess. In this paper, we describe an investigation into the effects of ageing
Gobet, F, Lane, PCR, Smith, RL
core