Results 51 to 60 of about 3,745,037 (345)

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

EPAM/CHREST tutorial: Fifty years of simulating human learning [PDF]

, 2009
Generating quantitative predictions for complex cognitive phenomena requires precise implementations of the underlying cognitive theory. This tutorial focuses on the EPAM/CHREST tradition, which has been providing significant models of human ...
Gobet, F, Lane, PCR
core  

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Simple environments fail as illustrations of intelligence: A review of R. Pfeifer and C. Scheier [PDF]

, 2001
The field of cognitive science has always supported a variety of modes of research, often polarised into those seeking high-level explanations of intelligence and those seeking low-level, perhaps even neuro-physiological, explanations.
Gobet, F, Lane, PCR
core  

Detection of Leishmania infantum by PCR, serology and cellular immune response in a cohort study of Brazilian dogs [PDF]

, 2001
The sensitivity and specificity of PCR, serology (ELISA) and lymphoproliferative response to Leishmania antigen for the detection of Leishmania infantum infection were evaluated in a cohort of 126 dogs exposed to natural infection in Brazil.
Courtenay, O., Davidson, S., Dye, C., Garcez, L.M., Lambson, B., Quinnell, R.J., Ramos, P., Shaw, J.J., Shaw, M.-A.   +8 more
core   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source

Learning perceptual schemas to avoid the utility problem [PDF]

, 1999
This paper describes principles for representing and organising planning knowledge in a machine learning architecture. One of the difficulties with learning about tasks requiring planning is the utility problem: as more knowledge is acquired by the ...
Cheng, PCH, Gobet, F, Lane, PCR
core  

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Identification of Listeria Isolates by Using a Pragmatic Multilocus Phylogenetic Analysis

Microbiology Research
Species identification of Listeria isolates remained a tedious process still based on culturing methods that, in recent years, have led to the description of many species that are not even part of the genus Listeria.
Antonio Martínez-Murcia, Aaron Navarro, Caridad Miró-Pina   +2 more
doaj   +1 more source

Computational models of the development of perceptual expertise [PDF]

, 2007
In a recent article, Palmeri, Wong and Gauthier have argued that computational models may help direct hypotheses about the development of perceptual expertise.
Campitelli, G, Gobet, F, Lane, PCR
core