Results 61 to 70 of about 4,063 (166)
Epilepsia, Volume 66, Issue 8, Page 3048-3063, August 2025.Abstract Objective KCNB1 encodes an α‐subunit of the delayed‐rectifier voltage‐dependent potassium channel Kv2.1. De novo pathogenic variants of KCNB1 have been linked to developmental and epileptic encephalopathies (DEEs), diagnosed in early childhood and sharing limited treatment options.
Lauralee Robichon +7 more
wiley +1 more source
The Role of Anti-mCRP Autoantibodies in Lupus Nephritis
Kidney Diseases, 2023 Background: Lupus nephritis is characterized by multiple autoantibodies production. However, there are few autoantibodies associated with disease activity and prognosis.
Mo Yuan, Ying Tan, Ming-hui Zhao
doaj +1 more source
Defeating lethal cancer: Interrupting the ecologic and evolutionary basis of death from malignancy
CA: A Cancer Journal for Clinicians, Volume 75, Issue 3, Page 183-202, May/June 2025.Abstract Despite the advances in cancer prevention, early detection, and treatments, all of which have led to improved cancer survival, globally, there is an increased incidence in cancer‐related deaths. Although each patient and each tumor is wholly unique, the tipping point to incurable disease is common across all patients: the dual capacity for ...
Kenneth J. Pienta +2 more
wiley +1 more source
Pediatric Endocrinology, Diabetes and MetabolismThe partial clinical recovery phase (PCRP), or “honeymoon period”, is a temporary and partial restoration of b-cell function in patients with type 1 diabetes mellitus (T1DM), in which the immune system attacks and destroys insulin-producing b-cells.
Forough Taheri +5 more
doaj +1 more source
Targeting conformational changes in C‐reactive protein to inhibit pro‐inflammatory actions
EMBO Molecular Medicine, 2022 C‐reactive protein (CRP) is a marker of acute inflammation and modulator of host defense against infections. CRP exists in conformationally distinct forms that exhibit opposing biological functions and could amplify tissue damage.
János G Filep
doaj +1 more source
Biochemically prepared C-reactive protein conformational states differentially affect C1q binding
BBA Advances, 2022 C-reactive protein (CRP) is commonly measured as an inflammatory marker in patient studies for coronary heart disease, autoimmune disease and recent acute infections.
Carrie L. Moon +4 more
doaj +1 more source
Advanced Science, Volume 12, Issue 20, May 29, 2025.As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang +10 more
wiley +1 more source
The DAXX co-repressor is directly recruited to active regulatory elements genome-wide to regulate autophagy programs in a model of human prostate cancer. [PDF]
, 2015 While carcinoma of the prostate is the second most common cause of cancer death in the US, current methods and markers used to predict prostate cancer (PCa) outcome are inadequate.
Benner, Christopher +2 more
core +2 more sources
Cancer Medicine, Volume 14, Issue 10, May 2025.ABSTRACT Background An unmet clinical need requires the discovery of new treatments for men facing advanced prostate cancer. Aberrant glycosylation is a universal feature of cancer cells and plays a key role in tumour growth, immune evasion and metastasis.
Kayla Bastian +28 more
wiley +1 more source
Targeting C-Reactive Protein in Inflammatory Disease by Preventing Conformational Changes
Mediators of Inflammation, 2015 C-reactive protein (CRP) is a pentraxin that has long been employed as a marker of inflammation in clinical practice. Recent findings brought up the idea of CRP to be not only a systemic marker but also a mediator of inflammation.
J. R. Thiele +5 more
doaj +1 more source