Results 21 to 30 of about 22,249,811 (294)
Revisiting the PD-1 pathway [PDF]
Science Advances, 2020 This review provides an overview of recent advances in understanding the interactions and signaling of PD-1 and its ligands.
Nikolaos Patsoukis +3 more
openaire +2 more sources
Animals, 2022 This study aimed at evaluating the relationship between biomarkers of oxidative stress (OS) in seminal plasma and sperm motility in bulls before and after cryopreservation. Three ejaculates per bull were collected from 20 young bulls.
Veronica Vigolo +6 more
doaj +1 more source
Tumor Infiltrating Lymphocyte Expression of PD-1 Predicts Response to Anti-PD-1/PD-L1 Immunotherapy [PDF]
Journal of Immunotherapy and Precision Oncology, 2022 Introduction: Many studies have focused on the role of programmed death receptor ligand 1 (PD-L1) expression in predicting immunotherapy outcomes. Limited clinical data are available regarding the role of programmed death receptor 1 (PD-1; the PD-L1 ...
Nicholas J. Bevins +5 more
doaj +1 more source
Frontiers in Immunology, 2022 Primary pulmonary lymphoepithelioma-like carcinoma (PLELC) is an Epstein–Barr virus (EBV)-related, rare subtype of non-small-cell lung cancer (NSCLC). Immune checkpoint inhibitors (ICI) show durable responses in advanced NSCLC. However, their effects and
Yu-Min Zhong +34 more
doaj +1 more source
PD-1 and PD-1 ligands: from discovery to clinical application [PDF]
International Immunology, 2007 Programmed cell death-1 (PD-1, Pdcd1), an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2.
Taku, Okazaki, Tasuku, Honjo
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USE OF NEAR INFRARED TECHNOLOGY TO PREDICT FATTY ACID GROUPS IN COMMERCIAL GROUND MEAT PRODUCTS [PDF]
Poljoprivreda, 2015 Near infrared transmittance (NIT, 850 to 1048 nm) spectroscopy was used to predict groups of fatty acids (FA), namely saturated FA (SFA), monounsaturated FA (MUFA) and polyunsaturated FA (PUFA), in commercial ground meat samples aiming to develope a fast
Sofia Ton +5 more
doaj +1 more source
Frontiers in Immunology, 2021 Immune checkpoint inhibitors, such as monoclonal antibodies targeting programmed death 1 (PD-1) and programmed death ligand-1 (PD-L1), have achieved enormous success in the treatment of several cancers.
Yuanyuan Wang +19 more
doaj +1 more source
PD-1, gender, and autoimmunity [PDF]
Autoimmunity Reviews, 2010 Programmed death 1 (PD-1) and its ligands (PD-L1 and PD-L2) are responsible for inhibitory T cell signaling that helps mediate the mechanisms of tolerance and immune homeostasis. The PD-1:PD-L signaling pathway has been shown to play an important role in a variety of diseases, including autoimmune conditions, chronic infection, and cancer.
Ravi K, Dinesh +2 more
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Critical Care, 2016 Increasing evidence suggests that after the first pro-inflammatory hours, sepsis is characterized by the occurrence of severe immunosuppression. Several mechanisms have been reported to participate in sepsis-induced immune alterations affecting both innate and adaptive immunity.
Monneret, Guillaume +2 more
openaire +3 more sources
PD-1/PD-L1 blockade accelerates the progression of atherosclerosis in cancer patients
, 2022 PD-1(programed death-1)/PD-L1(programed death-1 ligand) blockade represents a major breakthrough of anti-cancer therapies, however, it may come with increased risk of cardiovascular morbidity, such as myocarditis, acute coronary syndrome, arrhythmias ...
Tse, Gary +8 more
core +1 more source