Results 31 to 40 of about 676,789 (144)

Safety and antitumor activity of the anti–PD-1 antibody pembrolizumab in patients with advanced, PD-L1–positive papillary or follicular thyroid cancer

BMC Cancer, 2019
Background Treatment options for advanced thyroid cancer refractory to standard therapies are limited. The safety and efficacy of pembrolizumab were evaluated in patients with advanced differentiated thyroid cancer expressing programmed death ligand 1 ...
Janice M. Mehnert, Andrea Varga, Marcia S. Brose, Rahul R. Aggarwal, Chia-Chi Lin, Amy Prawira, Filippo de Braud, Kenji Tamura, Toshihiko Doi, Sarina A. Piha-Paul, Jill Gilbert, Sanatan Saraf, Pradeep Thanigaimani, Jonathan D. Cheng, Bhumsuk Keam   +14 more
doaj   +1 more source

Association of PD-1, PD-1 Ligands, and Other Features of the Tumor Immune Microenvironment with Response to Anti–PD-1 Therapy [PDF]

Clinical Cancer Research, 2014
Abstract Purpose: Immunomodulatory drugs differ in mechanism-of-action from directly cytotoxic cancer therapies. Identifying factors predicting clinical response could guide patient selection and therapeutic optimization. Experimental Design: Patients (N = 41) with melanoma, non–small cell lung carcinoma (NSCLC ...
Janis M, Taube, Alison, Klein, Julie R, Brahmer, Haiying, Xu, Xiaoyu, Pan, Jung H, Kim, Lieping, Chen, Drew M, Pardoll, Suzanne L, Topalian, Robert A, Anders   +9 more
openaire   +2 more sources

A Review of Mechanical Design Approaches for Balanced Robotic Manipulation

Robotics
Robot manipulators are suitable for many industrial tasks, such as assembly and pick-and-place operations. However, high-acceleration motions result in shaking forces and moments to the base, which can cause vibration of the manipulator and instability ...
Yash J. Vyas, Volkert van der Wijk, Silvio Cocuzza   +2 more
doaj   +1 more source

Bioinformatic analysis of PD-1 checkpoint blockade response in influenza infection

BMC Genomic Data, 2022
Background The programmed cell death 1 (PD-1)/PD-1 ligand 1 (PD-L1) signaling pathway is significantly upregulated in influenza virus infection, which impairs the antiviral response.
Huilin Ou, Keda Chen, Linfang Chen, Hongcheng Wu   +3 more
doaj   +1 more source

PD-1/PD-L1 axis in organ fibrosis

Frontiers in Immunology, 2023
Fibrosis is a pathological tissue repair activity in which many myofibroblasts are activated and extracellular matrix are excessively accumulated, leading to the formation of permanent scars and finally organ failure.
Youliang Zhao, Yaqian Qu, Changfu Hao, Wu Yao   +3 more
doaj   +1 more source

Analysis of Interaction Between Atmosphere and Sea Using The Delft3D Hydrodynamics Model for Mapping Coastal Flood Zone at Belawan Port and Coastal

Prisma Sains: Jurnal Pengkajian Ilmu dan Pembelajaran Matematika dan IPA IKIP Mataram, 2023
Belawan port and coastal areas were also not spared from the impact of the tidal flood. This study aims to determine the performance of the Delft3D hydrodynamic model in simulating sea level and waves in tidal floods at Belawan port and coastal area ...
Rizki Fadhillah Pratama Putra, Tulus Ikhsan Nasution, Syahrul Humaidi, Yahya Darmawan   +3 more
doaj   +1 more source

PD-1 Blockers

Cell, 2015
Nivolumab and pembrolizumab are monoclonal antibodies that block the programmed death-1 receptor (PD-1, CD279), resulting in dis-inhibition of tumor-specific immune responses. Both are recently approved for use in the treatment of metastatic melanoma, and nivolumab as well for non-small cell lung cancer.
openaire   +2 more sources

Effects of Summer Transhumance of Dairy Cows to Alpine Pastures on Body Condition, Milk Yield and Composition, and Cheese Making Efficiency

Animals, 2019
Summer transhumance to alpine pastures (ALP) is widespread in dairy systems of alpine regions. This study aimed to investigate the effects of transhumance of Brown Swiss cows to ALP on the yield, composition, and coagulation properties of milk (MCP), and
Sudeb Saha, Nicolò Amalfitano, Enrico Sturaro, Stefano Schiavon, Franco Tagliapietra, Giovanni Bittante, Ilaria Carafa, Elena Franciosi, Luigi Gallo   +8 more
doaj   +1 more source

Quantification of the growth suppression of HER2+ breast cancer colonies under the effect of trastuzumab and PD-1/PD-L1 inhibitor

Frontiers in Oncology, 2022
IntroductionImmune checkpoint blockade (ICB)-based therapy is revolutionizing cancer treatment by fostering successful immune surveillance and effector cell responses against various types of cancers.
Regina Padmanabhan, Hadeel Kheraldine, Hadeel Kheraldine, Ishita Gupta, Ishita Gupta, Nader Meskin, Anas Hamad, Semir Vranic, Ala-Eddin Al Moustafa, Ala-Eddin Al Moustafa   +9 more
doaj   +1 more source

Basal cell carcinoma: PD-L1/PD-1 checkpoint expression and tumor regression after PD-1 blockade

Journal for ImmunoTherapy of Cancer, 2017
Monoclonal antibodies that block immune regulatory proteins such as programmed death-1 (PD-1) have demonstrated remarkable efficacy in controlling the growth of multiple tumor types.
Megan Schollenberger, Evan Lipson, William H. Sharfman, Janis M. Taube, Haiying Xu, Aleksandra Ogurtsova, Jessica Esandrio, Mohammed T. Lilo, Patricia Brothers   +8 more
doaj   +1 more source