Results 31 to 40 of about 661,499 (148)
Antibodies, 2022 This study aimed to investigate PD-L1 and PD-1 expression in circulating CD20+ cells in diffuse larger B-cell lymphoma (DLBCL) and to evaluate the predictive and diagnostic performance of PD-L1 versus PD-1 expression in circulating CD20+ cells in DLBCL ...
Manal Mohamed Saber
doaj +1 more source
Immunotherapy protocols in lung cancer
Cancer Research, Statistics, and Treatment, 2018 Immunotherapy has emerged as a valuable treatment option in many advanced malignancies (especially lung cancer). The PD-1 inhibitors (nivolumab and pembrolizumab) and the PD-L1 inhibitors (durvalumab and atezolizumab) have been approved for use in ...
Nandini Menon, Sharada Mailankody
doaj +1 more source
Nature Immunology, 2019 Understanding resistance to antibody to programmed cell death protein 1 (PD-1; anti-PD-1) is crucial for the development of reversal strategies. In anti-PD-1-resistant models, simultaneous anti-PD-1 and vaccine therapy reversed resistance, while PD-1 blockade before antigen priming abolished therapeutic outcomes.
Vivek Verma +27 more
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The PD‐1 pathway in tolerance and autoimmunity [PDF]
Immunological Reviews, 2010 Summary: Regulatory T cells (Tregs) and the PD‐1: PD‐ligand (PD‐L) pathway are both critical to terminating immune responses. Elimination of either can result in the breakdown of tolerance and the development of autoimmunity. The PD‐1: PD‐L pathway can thwart self‐reactive T cells and protect against autoimmunity in many ways.
Loise M, Francisco +2 more
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Cell, 2015 Nivolumab and pembrolizumab are monoclonal antibodies that block the programmed death-1 receptor (PD-1, CD279), resulting in dis-inhibition of tumor-specific immune responses. Both are recently approved for use in the treatment of metastatic melanoma, and nivolumab as well for non-small cell lung cancer.
openaire +2 more sources
A Review of Mechanical Design Approaches for Balanced Robotic Manipulation
RoboticsRobot manipulators are suitable for many industrial tasks, such as assembly and pick-and-place operations. However, high-acceleration motions result in shaking forces and moments to the base, which can cause vibration of the manipulator and instability ...
Yash J. Vyas +2 more
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Bioinformatic analysis of PD-1 checkpoint blockade response in influenza infection
BMC Genomic Data, 2022 Background The programmed cell death 1 (PD-1)/PD-1 ligand 1 (PD-L1) signaling pathway is significantly upregulated in influenza virus infection, which impairs the antiviral response.
Huilin Ou +3 more
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PD-1/PD-L1 axis in organ fibrosis
Frontiers in Immunology, 2023 Fibrosis is a pathological tissue repair activity in which many myofibroblasts are activated and extracellular matrix are excessively accumulated, leading to the formation of permanent scars and finally organ failure.
Youliang Zhao +3 more
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BMC Cancer, 2019 Background Treatment options for advanced thyroid cancer refractory to standard therapies are limited. The safety and efficacy of pembrolizumab were evaluated in patients with advanced differentiated thyroid cancer expressing programmed death ligand 1 ...
Janice M. Mehnert +14 more
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Prisma Sains: Jurnal Pengkajian Ilmu dan Pembelajaran Matematika dan IPA IKIP Mataram, 2023 Belawan port and coastal areas were also not spared from the impact of the tidal flood. This study aims to determine the performance of the Delft3D hydrodynamic model in simulating sea level and waves in tidal floods at Belawan port and coastal area ...
Rizki Fadhillah Pratama Putra +3 more
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