Results 91 to 100 of about 54,977 (304)

Unraveling ERBB network dynamics upon betacellulin signaling in pancreatic ductal adenocarcinoma in mice

Molecular Oncology, 2020
Pancreatic ductal adenocarcinoma (PDAC) will soon belong to the top three cancer killers. The only approved specific PDAC therapy targets the epidermal growth factor receptor (EGFR).
Kathrin Hedegger, Hana Algül, Marina Lesina, Andreas Blutke, Roland M. Schmid, Marlon R. Schneider, Maik Dahlhoff   +6 more
doaj   +1 more source

Expression of BAFF receptors in human PDAC tissue and human PDAC cell lines.

, 2013
(A) Staining with hematoxylin and eosin (H&E) and immunohistochemistry of MIB-1, CA19-9, BAFF-R, TACI and BCMA in PDAC are shown. First Ab (-) indicates staining control without the first antibody. Magnification is as indicated above each photomicrograph.
Bunzo Matsuura (429489), Hirofumi Yamanishi (442548), Morikazu Onji (429490), Mitsuhito Koizumi (442547), Tetsuji Kobata (442550), Yoichi Hiasa (156596), Teru Kumagi (43326), Nobuaki Azemoto (442549), Masanori Abe (421879)   +8 more
core   +1 more source

Autophagy Orchestrates Anti‐Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP‐2 Axis in Colorectal Cancer

Advanced Science, EarlyView.
Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng, Chaoying Wei, Zhitong Niu, Jinxin Chen, Guojie Long, Yingzhen Weng, Qiufeng Liu, Yue Jiang, Panpan Wang, Ronghua Zhang, Qiang Yu, Xiaojian Wu, Wenyu Wang   +12 more
wiley   +1 more source

Targeted Treatment for KRAS12D For PDAC Treatment [PDF]

Introduction: Cellular stress is known to function in synergistic cooperation with oncogenic mutations during tumorigenesis to drive cancer progression.
Malik, Shabnam, Garcia, Orlando, Yallapu, Murali, Bulnes, Ana, Behrman, Stephen, Holla, Swathi, Dan, Nirnoy, Elizondo, Melissa, Shaji, Poornima Devi, Dhasmana, Anupam   +9 more
core   +1 more source

Metastatic PDAC Cell – Neutrophil Interaction Regulates their Proliferation and Survival [PDF]

, 2023
Tumor-promoting inflammation is a hallmark of cancer that contributes to tumor cells\u27 survival and proliferation. Infiltrating leukocytes and pro-inflammatory cytokines released into the tumor microenvironment (TME) often cause this inflammation ...
Tinsley, Parker, Sturgeon, Reegan, Maher, Michael, Singh, Rakesh, Johnson, Esther, Abrahams, Lauren   +5 more
core  

Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling

Advanced Science, EarlyView.
Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...
Fangzi Zha, Di Feng, Ziru Xue, Zhiying Liu, Xiaochen Lin, Zhe Wang, Ling Xu, Jasper Fuk Woo Chan, Martin Cheung, Michael Shing Yan Huen, Yusong Guo, Kui Ming Chan, Yun Liu, Bo Gao   +13 more
wiley   +1 more source

PDAC 2025 reúne a 27353 participantes en Toronto

La Asociación de Prospectores y Desarrolladores de Canadá (PDAC) celebró con éxito una nueva edición de su prestigiosa convención, PDAC 2025. Celebrada en Toronto, congregó a 27.353 participantes del sector minero interesados en oportunidades de ...
GĚRENS
core   +1 more source

Identification of Tumor‐Specific Surface Proteins Enables Quantification of Extracellular Vesicle Subtypes for Early Detection of Pancreatic Ductal Adenocarcinoma

Advanced Science
Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer‐related mortality, largely due to late‐stage diagnosis. Reliable early detection methods are critically needed.
Chen Zhao, Zhili Wang, Hyoyong Kim, Hui Kong, Junseok Lee, Jacqueline Ziqian Yang, Anmin Wang, Ryan Y. Zhang, Yong Ju, Jina Kim, Bing Feng, Dejun Liu, Yating Zhang, Zhenfang Wang, Yandong Zhang, Shujing Guo, Dekang Gao, James S. Tomlinson, Renjun Pei, Jipeng Wan, Stephen J. Pandol, Myung‐Shin Sim, Sungyong You, Ding Ma, Shaohua Lu, Na Sun, Hsian‐Rong Tseng, Yazhen Zhu   +27 more
doaj   +1 more source

Demographic data of patients with PDAC.

, 2014
Demographic data of patients with PDAC.
Amad Awadallah (516772), Wenbin Xiao (343825), Wei Xin (306299), Hong Hong (5657557), Lan Zhou (407521)   +4 more
core   +1 more source

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

Advanced Science, EarlyView.
AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.
Ying‐nan Wang, Dan‐yun Ruan, Jing Shi, Yue Huang, Hui Sheng, Ya‐ling Huang, Linjie Ma, Lijun Wang, Caiwei Chen, Yixuan Wang, Yue Zhang, Yi Shen, Qing Zhang, Jianjian Zhang, Yanfang Tang, Jin‐ling Zhang, Jia‐jia Hu, Chen‐yi Wu, Jia‐ying Chen, Xun Meng, Shu‐Hui Liu, Feng Wang   +21 more
wiley   +1 more source