Results 111 to 120 of about 54,977 (304)

CPT1A through succinylation regulates the CTCF/LINC01503‒91aa feedback loop to promote gemcitabine resistance in pancreatic ductal adenocarcinoma. [PDF]

Clin Transl Med
LINC01503 encoded a 91‐amino acid protein named 1503‒91aa, which enhanced carnitine palmitoyl transferase 1A (CPT1A) activity and regulated fatty acid oxidation (FAO) by competitively binding to malonyl‐CoA. Meanwhile, we found a positive feedback loop whereby CPT1A acts as a succinyltransferase to stabilise CTCF (a transcription factor driving ...
Fang DL, Lu SY, Liu ZD, Xu QC, Yu YY, Zhu YQ, Ma MJ, Ye JY, Yin XY.   +8 more
europepmc   +2 more sources

Defining the core gene regulatory network of PDAC cell identity

Pancreatic cancer is one of the deadliest forms of cancer and is the sixth leading cause of cancer-related deaths. The most common type of pancreatic cancer is pancreatic ductal adenocarcinoma (PDAC), which originates in the exocrine pancreas and ...
Alshaikh, Amani
core   +1 more source

CD86‐Positive Mature Tertiary Lymphoid Structures Are Associated With CD8+ T‐Cell Infiltration and Favorable Clinical Outcomes in Pancreatic Ductal Adenocarcinoma

Annals of Gastroenterological Surgery, EarlyView.
CD86‐positive mature tertiary lymphoid structures were associated with increased intratumoral CD8+ T‐cell infiltration, a higher proportion of Granzyme B‐expressing CD8+ T cells in an exploratory analysis, and favorable clinical outcomes in pancreatic ductal adenocarcinoma.
Takaomi Seki, Kenichiro Araki, Takehiko Yokobori, Hayato Ikota, Norio Kubo, Takamichi Igarashi, Mariko Tsukagoshi, Norihiro Ishii, Yasuo Hosouchi, Hiroshi Saeki, Ken Shirabe   +10 more
wiley   +1 more source

From pathogen to “living drug factory” innovative strategies and clinical translation of bacteria as programmable intelligent vectors for cancer therapy

BMEMat, EarlyView.
Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen, Weichen Zhang, Gaoli Niu, Li Wang, Ruiyan Li, Yueyue Fan, Feixue Lu, Lingling Xu, Xiaoyuan Ji, Yong Kang   +9 more
wiley   +1 more source

ArnaudStigliani/PDAC-organoids: PDAC_organoids_scripts_v1.0.0

No description ...
ArnaudStigliani, Evans
core   +1 more source

PON2 Promotes Glucose Uptake to Support PDAC Growth and Metastasis

, 2017
PON2 promotes GLUT1-mediated glucose transport, is upregulated in PDAC, and is required for PDAC growth.

core   +1 more source

Epigenetic Dysregulation of Somatostatin Receptors (SSTR) 1–5 and Therapeutic Implications in Neuroendocrine and Non‐Neuroendocrine Malignancies

International Journal of Cancer, EarlyView.
ABSTRACT Somatostatin receptors (SSTR) mediate the antiproliferative, antisecretory, and proapoptotic effects of somatostatin and its synthetic analogs. Their surface expression on neuroendocrine tumor (NET) cells is required for somatostatin analog therapy and radiopharmaceutical therapy (RPT).
Neeraj Kumari, Pablo Hoffmann, Laura Reichl, Maximilian Schmutz, Nina Fischer, Thi Tuong Vi Dang, Fulvia Ferrazzi, Pascal Johann, Michaela Kuhlen, Constantin Lapa, Rainer Claus   +10 more
wiley   +1 more source

Exploratory single-nucleus multiomics analysis of myeloid cell states associated with neoadjuvant chemotherapy response in pancreatic ductal adenocarcinoma. [PDF]

Clin Transl Med
Neoadjuvant‐treated PDAC tumors were stratified into responders and non‐responders based on CAP guidelines snRNA‐seq, snATAC‐seq, and spatial transcriptomics can be used to profile the neoadjuvant‐chemotherapy‐treated PDAC immune landscape. Our exploratory findings nominate candidate myeloid features for validation in larger cohorts and functional ...
Ojetunde M, Ma L, Goodney HG, Stevens AM, Mizener A, Pistilli EE, Ott S, Abdilleh K, Szomolay B, Hu G, Eubank TD, Boone BA.   +11 more
europepmc   +2 more sources

Clinical Translation of Patient‐Derived Organoids: Perspectives for Personalized Therapy in Cancer

International Journal of Cancer, EarlyView.
ABSTRACT Patient‐derived organoids (PDO) are accelerating precision medicine. These biological platforms allow for the autologous in vitro expansion of material from cancer patients in a considerably short period of time. These three‐dimensional models can faithfully recapitulate aspects of tissue heterogeneity, architecture, and relevant cellular ...
Haiyan Yue, Daniele Carchidi, Philipp Schmucker, Roland Seiler, Bernhard Kiss, Catarina Macedo‐Silva, Marianna Kruithof‐de Julio   +6 more
wiley   +1 more source

Cysteine Peptidases in Antitumor Immunity: Unraveling Antigen‐Presenting Cell Regulation and Therapeutic Potential

iMetaMed, EarlyView.
This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu, Xiaoyan Chen, Zichang Chen, Yalun Liang, Gokhan Zengin, Qian Zhang, Wenlong Sun, Meng‐Yao Li   +7 more
wiley   +1 more source