Results 131 to 140 of about 54,977 (304)

SIRT5’s GOT1 up on PDAC [PDF]

Gastroenterology, 2021
Surinder Kumar, David B. Lombard
openaire   +2 more sources

Prognostic Determinants of Overall Survival After Resection for Pancreatic Ductal Adenocarcinoma: A Consensus‐Based Conceptual Framework

Journal of Surgical Oncology, EarlyView.
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) carries a dismal prognosis despite surgical resection, yet the prognostic literature remains fragmented across hundreds of single‐institution studies that vary in design, covariates, and analytical approaches.
Muhammad Maisam Ali, Kaleem S. Ahmed, Clayton T. Marcinak, Syed Ali Tayyeb Hasan, Anne D. Letocha, Noorain Ahmad, Haider bin Khalid, Kainat Fatima, Syed Nabeel Zafar   +8 more
wiley   +1 more source

The GLP-1R agonist semaglutide reshapes pancreatic cancer associated fibroblasts reducing collagen proline hydroxylation and favoring T lymphocyte infiltration

Journal of Experimental & Clinical Cancer Research
Background Metabolic syndrome represents a pancreatic ductal adenocarcinoma (PDAC) risk factor. Metabolic alterations favor PDAC onset, which occurs early upon dysmetabolism.
Chiara Cencioni, Silvia Malatesta, Virginia Vigiano Benedetti, Valerio Licursi, Livia Perfetto, Federica Conte, Danilo Ranieri, Armando Bartolazzi, Martina Kunkl, Loretta Tuosto, Alberto Larghi, Geny Piro, Antonio Agostini, Giampaolo Tortora, Vincenzo Corbo, Carmine Carbone, Francesco Spallotta   +16 more
doaj   +1 more source

Outcomes Following Total Pancreatectomy With and Without Vascular Resection: A NSQIP Analysis Comparing Trends in Patient Selection and Outcomes Over 5 Years

Journal of Surgical Oncology, EarlyView.
ABSTRACT Introduction Advances in neoadjuvant therapy and surgical techniques have led to more total pancreatectomies (TP) with vascular resection for pancreatic cancer. This study assesses contemporary outcomes of TP with venous (VR) and arterial (AR) resections compared to non‐vascular resection (NVR).
Zofia Czarnecka, Kevin Verhoeff, A. M. James Shapiro, Chaya Shwaartz   +3 more
wiley   +1 more source

Detection of Pancreatic Cancer via Specific Metabolite Markers: A Metabolomics Approach. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies worldwide because most patients are diagnosed at advanced stages when curative treatment is no longer feasible. Metabolomics has emerged as a promising strategy for identifying biochemical alterations associated with early tumor development ...
Gourabi MJR, Ghafari M, Nikoo A, Saki YY, Khanbabaei B, Khanizadeh M, Kargar M, Hashemi A, Sharahi JY.   +8 more
europepmc   +2 more sources

Multimodal Neoadjuvant Therapy for Pancreatic Ductal Adenocarcinoma (PDAC) With Vascular Involvement: What Is the Impact of Radiation on Perioperative Outcomes, Local Control, and Survival?

Journal of Surgical Oncology, EarlyView.
ABSTRACT Objectives Neoadjuvant chemoradiation for PDAC with vascular invasion remains understudied. The aim of this study is to compare neoadjuvant chemotherapy with chemoradiation (NAC + CRT) versus neoadjuvant chemotherapy (NAC) for PDAC with vascular involvement.
Dhruv J. Patel, Lauren M. Janczewski, Joseph H. Cotler, George Molina, Brett L. Ecker, David Bentrem, Shishir K. Maithel, Mohamed E. Abazeed, John P. Hayes, Bryan Palis, Amanda B. Francescatti, Ronald J. Weigel, Judy Boughey, Lesly Dossett, Akhil Chawla   +14 more
wiley   +1 more source

Notch3 in normal pancreas and PDAC.

, 2013
a) Notch3 in the cytoplasm of normal pancreatic ductal epithelial cells; b) resected PDAC demonstrating strong cytoplasmic Notch3 with some positive nuclei; c) resected PDAC demonstrating largely nuclear stain; d) nuclear stain in an area of perineural ...
Christopher D. Mann (295856), Rajinder Singh (246689), Margaret M. Manson (295864), Christopher Bastianpillai (295858), Friederike Teichert (295862), Elena Karpova (272679), Muhammad M. Masood (295860), David P. Berry (295863), Christopher P. Neal (295859), Donald J. L. Jones (295861)   +9 more
core   +1 more source

Heterogeneity Analyzed by CT‐Based Habitat Analysis for Clinical Management of Cancers: A Narrative Review

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Tumors are highly heterogeneous, and whole‐lesion radiomics analysis is a popular method for extracting texture features that reflect this heterogeneity, which can be used to build models for cancer diagnosis, staging, therapy response evaluation, and prognosis prediction.
Yang Zhang, Zhi‐Yan Jin, Min‐Ying Lydia Su   +2 more
wiley   +1 more source

Targeting MYOF suppresses pancreatic ductal adenocarcinoma progression by inhibiting ILF3-LCN2 signaling through disrupting OTUB1-mediated deubiquitination of ILF3

Redox Biology
Pancreatic ductal adenocarcinoma (PDAC) is still a highly aggressive and fatal disease. The molecular mechanisms for PDAC progression are still not fully understood.
Zhihui Li, Jianlei Zhang, Jiang Yin, Wen Ma, Hongfan Liao, Lv Ling, Qingfeng Zou, Yabing Cao, Ying Song, Guopei Zheng, Xiaoye Hu, Guohua Yang, Nan Li   +12 more
doaj   +1 more source

Misp53 mutation-specific oncogenic transcription factor complexes in PDAC progression

Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second-leading cause of cancer related death by 2040 with a 5-year survival rate of only 11%.
Urbach, Laura
core   +1 more source