Results 121 to 130 of about 54,977 (304)

Establishment of a Transplantation Model of PDAC-Derived Liver Metastases [PDF]

Background: The highly metastatic nature of pancreatic ductal adenocarcinoma (PDAC) and the difficulty to achieve favorable patient outcomes emphasize the need for novel therapeutic solutions.
Schiavo Lena, Marco, Piemonti, Lorenzo, Ferrara, Benedetta, Marra, Paolo, Policardi, Martina, Esposito, Antonio, Doglioni, Claudio, Citro, Antonio, Dugnani, Erica, Camisa, Paolo Riccardo, Canu, Tamara   +10 more
core   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Targeting eIF5A combats breast cancer progression by ClpP‐dependent mitochondrial oxidative stress

Interdisciplinary Medicine, EarlyView.
This study identified the eIF5A‐ClpP axis as a key driver of breast cancer progression. Targeting eIF5A suppresses tumor growth by inducing ClpP‐dependent mitochondrial oxidative stress, revealing a novel therapeutic vulnerability. Abstract Breast cancer (BC) poses a persistent global health challenge, necessitating new therapeutic targets.
Jinmei Zhu, Baoyuan Tang, Bei Xie, Haohua Deng, Haitang Yang, Lei Ma, Ziqing Zhang, Yicheng Ma, Xingyuan Ma, Shuaiyang Wang, Jing Li, Lei Zhao, Wengui Shi, Linjing Li   +13 more
wiley   +1 more source

Targeting the intratumoral microbiota to overcome cancer immunotherapy resistance

Interdisciplinary Medicine, EarlyView.
This review delineates the mechanisms of intratumoral microbiota in cancer immunotherapy resistance, and offers strategies for microbiota‐targeted precision immunotherapy. Abstract Cancer remains a significant global health threat. The tumor microenvironment (TME) is a sophisticated ecological niche that exerts a pivotal effect on treatment outcomes ...
Bufu Tang, Tong Jiang, Yaling Lin, Wei Zhang, Hongjie Fan, Minjie Yang, Bingzhe Li, Yaozu Liu, Changyu Li, Xuran Jin, Wen Zhang, Zhiping Yan, Qianqian Zhao, Xuefeng Kan, Xudong Qu   +14 more
wiley   +1 more source

Triglyceride-glucose index and glycemic dynamics in pancreatic ductal adenocarcinoma: implications for disease progression and prognosis

Journal of Translational Medicine
Background To elucidate the relationship between the triglyceride-glycemic index (TyG) and clinical characteristics of pancreatic ductal adenocarcinoma (PDAC).
Yunda Song, Lingmin Jiang, Yuanxia Han, Subo Zhang, Shengping Li   +4 more
doaj   +1 more source

LCN2 expression in pancreatic neoplastic lesions and PDAC cell lines.

, 2012
(A) The LCN2 immunostaining pattern for normal (n = 31), PanIN1 (n = 22), PanIN-2 (n = 13), PanIN -3 and PDAC (n = 82). Mean scores and the SEM for LCN2 immunostaining are noted below the sections.
Christine To (129020), Chang-Qi Zhu (129006), Nikolina Radulovich (129004), Bizhan Bandarchi (129012), Devang Panchal (129024), Lisa Leung (129001), Ming Sound Tsao (67676), Shawna Organ (129008), Melania Pintilie (129016)   +8 more
core   +1 more source

Plasma Proteomic Profiling Identifies Candidate Biomarkers for Pancreatic Ductal Adenocarcinoma

Journal of Clinical Laboratory Analysis, EarlyView.
Using DIA‐based plasma proteomics followed by ELISA validation, we identified eight circulating proteins that were significantly elevated in patients with pancreatic ductal adenocarcinoma. These proteins reflect key tumor‐associated biological processes, including exocrine dysfunction and immune remodeling, and may serve as candidates for future multi ...
Lelang Xiang, Yi Jin, Ran Hu, Yuhang He, Yong Zhang, Ang Li   +5 more
wiley   +1 more source

Independent Prognostic Value of Natural Tooth Count Versus Posterior Teeth Occlusion in Resected Pancreatic Cancer

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background/Purpose Prognostic significance of preoperative patient‐related factors, including oral health status, in pancreatic ductal adenocarcinoma (PDAC) remains unclear. We evaluated the association between preoperative factors—particularly oral health parameters—and long‐term survival after curative PDAC resection.
Kaoru Seo, Kenichiro Uemura, Kenjiro Okada, Hiromi Nishi, Tatsuaki Sumiyoshi, Ryuta Shintakuya, Yoshiaki Murakami, Hiroyuki Kawaguchi, Shinya Takahashi   +8 more
wiley   +1 more source

Loss of a primary cilium in PDAC [PDF]

Cell Cycle, 2017
Tetsuo, Kobayashi, Hiroshi, Itoh
openaire   +2 more sources

Impact of Neoadjuvant Approach and Tumor Response on Survival in Pancreatic Adenocarcinoma

Journal of Surgical Oncology, EarlyView.
ABSTRACT Introduction Neoadjuvant therapy for pancreatic adenocarcinoma (PDAC) has evolved from single‐agent to multi‐agent approaches, largely informed by metastatic disease studies demonstrating improved survival; albeit at the price of increased toxicity. It remains unclear how response to varied neoadjuvant regimens impact survival. We hypothesized
Mohammed O. Suraju, Brian Longbottom, Jasmine A. Peterson, Terry Hayes, Kiers Brevik, Sean Y. Kim, Paolo Goffredo, Imran Hassan, Hassan Aziz, Carlos H. F. Chan   +9 more
wiley   +1 more source