Results 141 to 150 of about 54,977 (304)

Hey-1 in normal pancreas and PDAC.

, 2013
a) Normal pancreas showing faint cytoplasmic stain for Hey-1; b) resected PDAC demonstrating cytoplasmic, but no nuclear, staining; c) resected PDAC demonstrating nuclear expression; d) area of perineural invasion in a resected tumour demonstrating ...
Christopher D. Mann (295856), Rajinder Singh (246689), Margaret M. Manson (295864), Christopher Bastianpillai (295858), Friederike Teichert (295862), Elena Karpova (272679), Muhammad M. Masood (295860), David P. Berry (295863), Christopher P. Neal (295859), Donald J. L. Jones (295861)   +9 more
core   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

HOXA9 and CD163 potentiate pancreatic ductal adenocarcinoma progression

Diagnostic Pathology
Background The role of HOXA9 requires investigations in pancreatic ductal adenocarcinoma (PDAC) as HOXA9 inhibitors are being developed. HOXA9 might attract CD163 expressed tumor associated macrophages (TAM) and could affect PDAC prognosis.
Aiat Shaban Hemida, Mohamed Mohamady Ahmed, Mona Saeed Tantawy   +2 more
doaj   +1 more source

Pancreatic surgery is safe in elder patients with PDAC

BMC Geriatrics
Abstract Background: In aging society, more and more elder people is diagnosed with pancreatic ductal adenocarcinoma (PDAC), unfortunately, these patients didn’t receive proper treatment compared to the non-elderly. Currently, there is controversy on whether surgery is safe in elderly pancreatic cancer patients.
Zhang, Yueming, Han, Siyang, Xu, Yaolin, Liu, Liang, Wu, Wenchuan, Zhang, Lei, Shi, chenye, Song, Chao, Wang, Dansong, Lou, Wenhui   +9 more
openaire   +2 more sources

PDAC-based underactuated 3D bipedal walking : Stabilization of PDAC constants and walking direction control

This paper proposes a three-dimensional biped dynamic walking algorithm based on passive dynamic autonomous control (PDAC) which is previously proposed.
Hasegawa, Yasuhisa, Sekiyama, Kosuke, Aoyama, Tadayoshi, Fukuda, Toshio   +3 more
core  

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

Chemopreventive Effect of Bitter Melon (Momordica charantia) Juice on Pancreatic Carcinogenesis in LSL‐KrasG12D/+; p48Cre/+ Mice

Molecular Carcinogenesis, EarlyView.
ABSTRACT Herein, using the LSL‐KrasG12D/+; p48Cre/+ transgenic mouse model [that recapitulates the full spectrum of human disease, progressing from early pancreatic intraepithelial neoplasia lesions to invasive pancreatic ductal adenocarcinoma (PDAC)], we determined the chemopreventive effect of long‐term (chronic) administration of Bitter Melon Juice (
Lakshmi Sai Pratyusha Bugata, Deepanshi Dhar, Rama Kant, Robin Kumar, Md. Imtiazul Kabir, Chapla Agarwal, Rajesh Agarwal, Komal Raina   +7 more
wiley   +1 more source

Artificial Intelligence for Identifying Tumor‐Reactive CD8+ T Cells: Biological Principles, Computational Advances, and Future Directions

Med Research, EarlyView.
This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang, Yingying Sun, Yan Zhang, Yifen Shi, Zhiwen Shi   +4 more
wiley   +1 more source

Treatment of hepatic pancreatic ductal adenocarcinoma metastases with high-dose-rate image-guided interstitial brachytherapy: a single center experience

Journal of Contemporary Brachytherapy, 2019
Ralph Drewes, Jazan Omari, Matthias Manig, Max Seidensticker, Peter Hass, Jens Ricke, Maciej Powerski, Maciej Pech   +7 more
doaj   +1 more source

Organoid Coculture Models for Cancer Research and Immunotherapy

Med Research, EarlyView.
This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang, Huihui Yang, Guangxin Li, Guobang Liu, Zhulan Chen, Wenzhi Tian, Meiyang Huang, Xiaoling Liu, Yongsheng Zhao, Dong Chen   +9 more
wiley   +1 more source