Results 141 to 150 of about 85,787 (336)

Blockade of CC chemokine receptor 2 suppresses pancreatic cancer progression through the interaction with macrophages in the tumor microenvironment

Scientific Reports
Pancreatic ductal adenocarcinoma (PDAC) is the most intractable cancer, demonstrating abundant stroma in the tumor microenvironment (TME). Previously, we reported that CXC chemokines contributed to the progression of PDAC through tumor-stromal ...
Gen Kimura, Hideaki Ijichi, Makoto Sano, Genso Notoya, Koji Miyabayashi, Ryota Takahashi, Takahiro Kishikawa, Mitsuhiro Fujishiro   +7 more
doaj   +1 more source

PDAC-ANN: an artificial neural network to predict pancreatic ductal adenocarcinoma based on gene expression

BMC Cancer, 2019
Although the pancreatic ductal adenocarcinoma (PDAC) presents high mortality and metastatic potential, there is a lack of effective therapies and a low survival rate for this disease.
P. P. Almeida, C. Cardoso, L. M. de Freitas   +2 more
semanticscholar   +1 more source

A general approach to high-yield biosynthesis of chimeric RNAs bearing various types of functional small RNAs for broad applications. [PDF]

, 2015
RNA research and therapy relies primarily on synthetic RNAs. We employed recombinant RNA technology toward large-scale production of pre-miRNA agents in bacteria, but found the majority of target RNAs were not or negligibly expressed. We thus developed a
Chen, Qiu-Xia, Urayama, Shiro, Wang, Wei-Peng, Yu, Ai-Ming, Zeng, Su   +4 more
core   +2 more sources

From Cell‐Free Transcriptomes to Single‐Cell Landscapes: Biomarker Discovery and Originating Cell Alteration Analysis via Graph Matrix Factorization

Advanced Science, EarlyView.
CellFreeGMF traces plasma cfRNA to likely originating cell types by integrating single‐cell atlases with graph‐regularized matrix factorization. The method decomposes cfRNA profiles into sample–cell contributions to reconstruct pseudo single‐cell expression.
Wenxiang Zhang, Wenjing Zhang, Hang Wei, Shiyan Liu, Junliang Shang, Weijie Gong, Hanwen Cheng, Xiujuan Lei, Yuhui Kou, Baoguo Jiang   +9 more
wiley   +1 more source

Rising Pancreatic Cancer Incidence in Young Japanese Women and Increasing Distal Pancreatectomy in Older Adults: A Nationwide Claims‐Based Analysis From 2016 to 2023

Annals of Gastroenterological Surgery, EarlyView.
This nationwide claims‐based study analyzed recent trends in pancreatic cancer incidence (2016–2021) and surgery (2016–2023) in Japan. The study revealed a rising incidence of pancreatic cancer, notably among young women, and an increasing use of distal pancreatectomy among older adults.
Masamitsu Kido, Ryo Morimura, Yusuke Yamamoto, Tomohiro Arita, Shingo Nakashima, Katsutoshi Shoda, Taisuke Imamura, Hidemasa Kubo, Kengo Yoshii, Iichiroh Onishi, Atsushi Shiozaki   +10 more
wiley   +1 more source

Transcriptome-wide association study and Mendelian randomization in pancreatic cancer identifies susceptibility genes and causal relationships with type 2 diabetes and venous thromboembolismResearch in context

EBioMedicine
Summary: Background: Two important questions regarding the genetics of pancreatic adenocarcinoma (PDAC) are 1. Which germline genetic variants influence the incidence of this cancer; and 2.
Marcus C.B. Tan, Chelsea A. Isom, Yangzi Liu, David-Alexandre Trégouët, Lang Wu, Dan Zhou, Eric R. Gamazon, Sara Lindstrom, Lu Wang, Erin Smith, William Gordon, Astrid Van Hylckama Vlieg, Mariza De Andrade, Jennifer Brody, Jack Pattee, Jeffrey Haessler, Ben Brumpton, Daniel Chasman, Pierre Suchon, Ming-Huei Chen, Constance Turman, Marine Germain, Kerri Wiggins, James MacDonald, Sigrid Braekkan, Sebastian Armasu, Nathan Pankratz, Rabecca Jackson, Jonas Nielsen, Franco Giulianini, Marja Puurunen, Manal Ibrahim, Susan Heckbert, Theo Bammler, Kelly Frazer, Bryan McCauley, Kent Taylor, James Pankow, Alexander Reiner, Maiken Gabrielsen, Jean-François Deleuze, Chris O'Donnell, Jihye Kim, Barbara McKnight, Peter Kraft, John-Bjarne Hansen, Frits Rosendaal, John Heit, Bruce Psaty, Weihong Tang, Charles Kooperberg, Kristian Hveem, Paul Ridker, Pierre-Emmanuel Morange, Andrew Johnson, Christopher Kabrhel, David-Alexandre Trégouët, Nicholas Smith   +57 more
doaj   +1 more source

Downregulated miR-98-5p promotes PDAC proliferation and metastasis by reversely regulating MAP4K4

Journal of experimental & clinical cancer research : CR, 2018
The aberrant expression of microRNAs (miRNAs) has emerged as important hallmarks of cancer. However, the molecular mechanisms underlying the differences of miRNA expression remain unclear.
Yue Fu, Xinchun Liu, Qiuyang Chen, Tongtai Liu, Cheng Lu, Jun Yu, Y. Miao, Jishu Wei   +7 more
semanticscholar   +1 more source

Prognostic Significance of Portal Vein Tumor Thrombus in Pancreatic Ductal Adenocarcinoma Treated With Chemoradiotherapy

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim To examine the significance of portal vein tumor thrombus (PVTT) as a prognostic factor for patients with pancreatic ductal adenocarcinoma (PDAC) treated with chemoradiotherapy (CRT) followed by surgery. Methods The study retrospectively examined 313 patients with borderline resectable (BR) or locally advanced (LA) PDAC who underwent CRT ...
Aoi Hayasaki, Motonori Nagata, Miki Usui, Hiroshi Imai, Yusuke Iizawa, Akihiro Tanemura, Yasuhiro Murata, Naohisa Kuriyama, Masashi Kishiwada, Shugo Mizuno   +9 more
wiley   +1 more source

Preoperative Gemcitabine/Nab‐Paclitaxel With Concurrent Radiation Therapy for Borderline Resectable Pancreatic Cancer: A Comparative Analysis With Preoperative Chemoradiation Therapy Using Gemcitabine Alone

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Although NCCN guidelines recommend preoperative therapy for borderline resectable pancreatic cancer (BR‐PC), it is still unclear which regimen is better. The study objective was to elucidate the prognostic significance of neoadjuvant chemoradiotherapy (NACRT) with gemcitabine/nab‐paclitaxel (GnP‐RT) compared to gemcitabine alone ...
Hirofumi Akita, Hidenori Takahashi, Yousuke Mukai, Masahiko Kubo, Shinichiro Hasegawa, Masayoshi Yasui, Takeshi Omori, Hiroshi Miyata, Hiroshi Wada, Kunihito Gotoh   +9 more
wiley   +1 more source

Oncogenic Activities Of UBE2S Mediated By VHL/HIF-1α/STAT3 Signal Via The Ubiquitin-Proteasome System In PDAC

OncoTargets and Therapy, 2019
Purpose Ubiquitin-conjugating enzyme E2S (UBE2S) is important for the development and progression of several types of cancer. However, neither the role of UBE2S in pancreatic cancer nor its mechanism is clear.
Lei Wang, Yiyi Liang, Pengping Li, Qingchun Liang, Haijun Sun, Dazhou Xu, Wei Hu   +6 more
semanticscholar   +1 more source