Results 151 to 160 of about 85,787 (336)
Advances in Digestive Medicine, EarlyView.Abstract Recent trends show an alarming rise in pancreatic cancer prevalence among young individuals. Previous studies have presented differences in age at diagnosis. The study aimed to examine the likelihood of a younger age at diagnosis in individuals exposed to known risk factors, compared with those without exposure.
Ro‐Ting Lin +6 more
wiley +1 more source
Molecular Therapy: Nucleic Acids, 2019 Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies; it preferentially metastasizes to the liver and is the main cause of death from this disease.
Sorah Yoon +8 more
semanticscholar +1 more source
Precision delivery of RAS-inhibiting siRNA to KRAS driven cancer via peptide-based nanoparticles [PDF]
, 2019 Over 95% of pancreatic adenocarcinomas (PDACs), as well as a large fraction of other tumor types, such as colorectal adenocarcinoma, are driven by KRAS activation. However, no direct RAS inhibitors exist for cancer therapy.
Bi, Ye +14 more
core +1 more source
Advanced Intelligent Systems, EarlyView.gnSPADE integrates gene‐network structures into a probabilistic topic modeling framework to achieve reference‐free cell‐type deconvolution in spatial transcriptomics. By embedding gene connectivity within the generative process, gnSPADE enhances biological interpretability and accuracy across simulated and real datasets, revealing spatial organization ...
Aoqi Xie, Yuehua Cui
wiley +1 more source
Advanced NanoBiomed Research, EarlyView.This review explains how biomaterials and nanoparticles can be used to induce or modulate tertiary lymphoid structures (TLSs), which are ectopic immune hubs that form in nonlymphoid tissues during chronic disease and cancer. By comparing different methods, the article highlights design principles for modeling TLSs or recapitulating specific TLS ...
Shaza Karaman, Mei ElGindi, Jeremy Teo
wiley +1 more source
Advanced NanoBiomed Research, EarlyView.Using a 3D cell culture model of the fibrotic barrier in pancreatic cancer, this work shows that inhibiting NUAK2 kinase in pancreatic stellate cells enhances macromolecular drug delivery. Mechanistically, NUAK2 inhibition disrupted actin stress fiber assembly to downregulate collagen I expression, thus enhancing macromolecular permeability.
Misaki Nakamura +14 more
wiley +1 more source
Advanced NanoBiomed Research, EarlyView.Redox responsive mesoporous silica nanoparticles (MSNs) were engineered to deliver gemcitabine (Gem) and cisplatin (cisPt) at defined ratios to overcome chemoresistance in pancreatic ductal adenocarcinoma (PDAC). Optimized Gem MSNs and Gem cisPt MSNs enhanced cytotoxicity in murine and human Gem resistant models, with select formulations inducing ...
Tamanna Binte Huq +5 more
wiley +1 more source
Diagnostic Cytopathology, EarlyView.ABSTRACT Background Pancreatic adenocarcinoma (PDAC) is characterized by its poor prognosis. Cytology is essential for diagnostic confirmation and ancillary studies. The endoscopic ultrasound (EUS) set a precedent, facilitating cytological sampling through fine‐needle aspiration (FNA), with a sensitivity of 93% and a specificity of 95%.
Judith González‐López +10 more
wiley +1 more source
Plasmonic Heterojunction Nanomaterials for Noninvasive Pan‐Cancer Metabolomic Screening
Interdisciplinary Materials, EarlyView.This study develops gold nanoparticle‐modified manganese–cobalt oxide heterjunctions (Au/MCOM) as a laser desorption/ionization mass spectrometry (LDI‐MS) matrix for acquiring serum metabolic fingerprints. Combined with machine learning, the platform achieves accurate detection and early screening across six cancer types, demonstrating strong potential
Jia Qi +5 more
wiley +1 more source
International Journal of Cancer, EarlyView.What's New? Pancreatic ductal adenocarcinoma is characterized by a dense extracellular matrix, and how invasive tumor cells overcome such biomechanical constraints remains unclear. This study identifies the actin‐related protein 2/3 complex as a key regulator of pancreatic ductal adenocarcinoma invasiveness, driving fibroblast migration through β1 ...
Xiufen Yang +15 more
wiley +1 more source