Results 11 to 20 of about 85,787 (336)
Cells, 2020 Increased metabolic acid production and upregulation of net acid extrusion render pH homeostasis profoundly dysregulated in many cancers. Plasma membrane activity of vacuolar H+ ATPases (V-ATPases) has been implicated in acid extrusion and invasiveness ...
Mette Flinck +7 more
doaj +1 more source
Modifiable Pancreatic Ductal Adenocarcinoma (PDAC) Risk Factors
Journal of Clinical Medicine, 2023 This study aims to summarize the modifiable risk factors for pancreatic ductal adenocarcinoma (PDAC) that have been known for a long time, as well as information from the most recent reports. As a cancer with a late diagnosis and poor prognosis, accurate
N. Michalak, E. Małecka-Wojciesko
semanticscholar +1 more source
Cancers, 2022 Simple Summary This review takes the extracellular matrix (ECM) as the starting point, and describes its influence and related mechanisms on the biological behavior of pancreatic ductal carcinoma (PDAC).
Dan Wang +5 more
semanticscholar +1 more source
Interrelationship between miRNA and splicing factors in pancreatic ductal adenocarcinoma
Epigenetics, 2022 Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers because of diagnosis at late stage and inherent/acquired chemoresistance.
I Gede Putu Supadmanaba +8 more
doaj +1 more source
Frontiers in Oncology, 2021 Pancreatic ductal adenocarcinoma (PDAC) is notorious for a dense fibrotic stroma that is interlaced with a collagen-based extracellular matrix (ECM) that plays an important role in tumor biology.
Vincent M. Perez, J. Kearney, J. Yeh
semanticscholar +1 more source
Mechanisms of PDAC subtype heterogeneity and therapy response.
Trends in Cancer, 2022 Pancreatic ductal adenocarcinoma (PDAC) is clinically challenging due to late diagnosis and resistance to therapy. Two major PDAC subtypes have been defined based on malignant epithelial cell gene expression profiles; the basal-like/squamous subtype is ...
Elisa Espinet +3 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer, which is presently refractory to all available therapeutic strategies. PDAC tumors are characterized by a high degree of fibrosis, believed to be a major contributor to their
Martino Maddalena +19 more
semanticscholar +1 more source
Autoimmunity, 2022 Background The hsa_circRNA_103809 (circ_0072088) has been an emerging tumour regulator in human cancers, and is identified as one most aberrantly expressed circRNA in patients with pancreatic ductal adenocarcinoma (PDAC).
Hui Sun, Fang Liu, Hongqing Zhang
doaj +1 more source
Cancer Biology & Medicine, 2023 Objective: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy. CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB) have been significantly correlated with the outcome of patients with PDAC, but the correlations have been ...
Tianxing Zhou +11 more
doaj +1 more source
Targeting Pancreatic Ductal Adenocarcinoma (PDAC) [PDF]
Cellular Physiology and Biochemistry, 2020 Pancreatic cancers are among the most ominous, and among the most studied. Their complexities have provided ample material for a huge investigative effort, which is briefly surveyed in this review. Eradication by surgery has proven extremely difficult, and a successful chemotherapeutic approach is desperately needed.
Sofia Parrasia +6 more
openaire +5 more sources