Results 191 to 200 of about 85,787 (336)

Coenzyme A mitigates cystine‐deprivation‐induced ferroptosis by suppressing the iron‐starvation response

The FEBS Journal, EarlyView.
Cystine (Cys2) deprivation in pancreatic cancer cells induces oxidative stress that destabilizes cytosolic iron–sulfur cluster (ISC) proteins, triggering an iron‐regulatory protein (IRP)‐mediated iron‐starvation response (ISR). This leads to increased iron uptake (via TFRC), an expanded labile iron pool, and ferroptosis.
Mingjun Tan, Yunzhan Li, Lei Sang, Min Wang, Qin Li, Zekun Li, Dongxiao Sun, Xiuchao Wang, Shengyu Yang   +8 more
wiley   +1 more source

Aquaporin‐1 differentiates intrahepatic cholangiocarcinoma from liver metastases of pancreatic ductal adenocarcinoma

Histopathology, EarlyView.
Differentiating intrahepatic CCA from PDAC metastatic to the liver is critical for the clinical management of patients with pancreatobiliary cancers. AQP1 has demonstrated an excellent discriminatory performance in this clinical scenario. Aims Differentiating intrahepatic cholangiocarcinoma (iCCA) from metastatic ductal adenocarcinoma of the pancreas ...
Leoncini Giuseppe, Barella Marco, Droz Dit Busset Michele, Gentili Marco, Bodini Beatrice, Ronchetti Simona, Cari Luigi, Mazzaferro Vincenzo   +7 more
wiley   +1 more source

Endoscopic Ultrasound for the Management of Pancreatic Neuroendocrine Tumors: Diagnosis, Treatment, and Future Perspectives

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Pancreatic neuroendocrine tumors (PanNETs) are increasingly diagnosed, reflecting greater clinical awareness, improved imaging, and revised classification. This review summarizes evidence on epidemiology, diagnostic workup, and endoscopic ultrasound (EUS)–guided management of PanNETs, encompassing diagnostic evaluation, tissue acquisition, and
Angelo Bruni, David Meacci, Roberto Falbo, Marco Fichera, Francesco Poggioli, Riccardo Casadei, Claudio Ricci, Leonardo Henry Eusebi   +7 more
wiley   +1 more source

Treatment landscape from first‐ to third‐line therapy and quality of life data of patients with pancreatic cancer from the prospective German PARAGON (Platform for Outcome, Quality of Life, and Translational Research on Pancreatic Cancer) registry (IKF‐PARAGON study)

International Journal of Cancer, Volume 158, Issue 10, Page 2560-2570, 15 May 2026.
What's New? Pancreatic cancer often is diagnosed at advanced stages. As a result, treatment regimens frequently are aggressive, with substantial side effects that impact quality of life (QoL). This study examined the treatment landscape, from neoadjuvant therapy to palliative care, in the context of QoL among pancreatic cancer patients in Germany. Most
Thorsten O. Goetze, Salah‐Eddin Al‐Batran, Ruediger Liersch, Lars Scheuer, Thomas Goehler, Ulrich Kaiser, Claudio Denzlinger, Stephan Brandl, Daniel Pink, Jens Uhlig, Michael Maasberg, Maria Loose, Marina Schaaf, Disorn Sookthai, Bianca Zäpf, Claudia Pauligk, Timursah Habibzade, Ralf‐Dieter Hofheinz, Christine Koch, for the AIO Study Group   +19 more
wiley   +1 more source

TCF7L2/DEPDC1 axis contributes to tumor progression by promoting cell proliferation, aerobic glycolysis, and immunosuppression in pancreatic cancer. [PDF]

Clin Exp Med
Tasiheng Y, Kenjiabieke J, Tasiheng N, Adilijiang K, Cheng H.   +4 more
europepmc   +1 more source

Adequacy evaluation of 22‐gauge needle endoscopic ultrasound‐guided tissue acquisition samples and glass slides preparation for successful comprehensive genomic profiling testing: A single institute experience

DEN Open, Volume 6, Issue 1, April 2026.
Abstract Objectives This study aimed to evaluate the successful sequencing rate of Foundation One CDx (F1CDx) using small tissue samples obtained with a 22‐gauge needle (22G) through endoscopic ultrasound‐guided fine needle acquisition (EUS‐TA) and to propose guidelines for tissue quantity evaluation criteria and proper slide preparation in clinical ...
Tami Nagatani, Yoji Wani, Masahiro Takatani, Soichiro Fushimi, Hirofumi Inoue, Shinichiro Hori, Kyohei Kai, Hideki Yamamoto, Tetsuya Okazaki, Maki Tanioka, Hiroyuki Okada, Akira Hirasawa   +11 more
wiley   +1 more source

Rupture of Life‐Threatening Hepatic Artery Pseudoaneurysm After Endoscopic Ultrasonography‐guided Hepaticogastrostomy: Successful Management With Emergency Transcatheter Arterial Embolization

DEN Open, Volume 6, Issue 1, April 2026.
Abstract A 70‐year‐old male with lung cancer and interstitial pneumonia was diagnosed with ampullary carcinoma, causing obstructive jaundice. After the failure of endoscopic retrograde cholangiopancreatography, endoscopic ultrasound‐guided hepaticogastrostomy (EUS‐HGS) was performed with a 7‐Fr plastic stent (PS) into the B2 bile duct.
Hiroshi Yukimoto, Akino Okamoto, Kohsaku Ohnishi, Keitaro Masuko, Junping Wang, Kazuya Ogawa, Ken Ueda, Motohiro Hirao, Yasuhiro Nakaya, Atsushi Hosui   +9 more
wiley   +1 more source

Protein-level profiling of TIGIT axis components in human PDAC reveals immune-suppressive expression patterns. [PDF]

Cancer Immunol Immunother
Quatannens D, Verhoeven Y, van der Heijden S, Peeters D, Claes J, Hermans C, Lambrechts H, Zwaenepoel K, van Dam P, Peeters M, Prenen H, Koljenovic S, De Waele J, Faes C, Lardon F, Roeyen G, Smits E, Van Audenaerde J.   +17 more
europepmc   +1 more source

A Case of Pancreatic Neuroendocrine Tumor Growing Intraductal Extension toward the Main Pancreatic Duct Complicated by Thrombocytopenia: Diagnostic Challenges and Management Strategy

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT We present a rare and diagnostically challenging case of a pancreatic neuroendocrine tumor (pNET) with intraductal growth into the main pancreatic duct (MPD), complicated by severe thrombocytopenia due to myelodysplastic syndrome. A 37‐year‐old male presented with thrombocytopenia.
Koichi Soga, Kazuma Sakakibara, Yuki Soma, Manayu Shiina, Mayumi Yamaguchi, Masaru Kuwada, Ryosaku Shirahashi, Ikuhiro Kobori, Shinichi Ban, Masaya Tamano   +9 more
wiley   +1 more source

Exocyst complex regulates fungal-mediated IL-33 release from cancer cells. [PDF]

Signal Transduct Target Ther
Alam A, Mayengbam SS, Abrams SI, Qu J, Dey P.   +4 more
europepmc   +1 more source