Results 61 to 70 of about 85,787 (336)

Increased SPARC expression is associated with neoadjuvant therapy in resectable pancreatic ductal adenocarcinoma

Practical Laboratory Medicine, 2020
Secreted Protein Acid and Rich in Cysteine (SPARC) is an extracellular glycoprotein secreted by fibroblasts and osteoblasts in normal tissues. SPARC overexpression occurs in multiple tumors including pancreatic ductal adenocarcinoma (PDAC) and may ...
Christopher Hartley, Daniel Rowan, Xiuxu Chen, Luisa Gomez-Arellano, Anna Marie West, Kiyoko Oshima, Alexander Craig Mackinnon   +6 more
doaj   +1 more source

Integrated analysis revealed hypoxia signatures and LDHA related to tumor cell dedifferentiation and unfavorable prognosis in pancreatic adenocarcinoma

Translational Oncology, 2023
Pancreatic ductal adenocarcinoma (PDAC) is a highly heterogeneous cancer with limited understanding of its classification and tumor microenvironment.
Mingwei Dong, Rong Tang, Wei Wang, Jin Xu, Jiang Liu, Chen Liang, Jie Hua, Qingcai Meng, Xianjun Yu, Bo Zhang, Si Shi   +10 more
doaj   +1 more source

Do changes in health reveal the possibility of undiagnosed pancreatic cancer? Development of a risk-prediction model based on healthcare claims data. [PDF]

, 2019
Background and objectiveEarly detection methods for pancreatic cancer are lacking. We aimed to develop a prediction model for pancreatic cancer based on changes in health captured by healthcare claims data.MethodsWe conducted a case-control study on 29 ...
Baecker, Aileen, Hendifar, Andrew E, Jeon, Christie Y, Kim, Sungjin, Nuckols, Teryl K, Pandol, Stephen J, Pisegna, Joseph R, Risch, Harvey A, Wu, Bechien U   +8 more
core   +2 more sources

Noninvasive detection of pancreatic ductal adenocarcinoma using the methylation signature of circulating tumour DNA

BMC Medicine, 2022
Background Pancreatic ductal adenocarcinoma (PDAC) has the lowest overall survival rate primarily due to the late onset of symptoms and rapid progression. Reliable and accurate tests for early detection are lacking. We aimed to develop a noninvasive test
Huanwen Wu, Shiwei Guo, Xiaoding Liu, Yatong Li, Zhixi Su, Qiye He, Xiaoqian Liu, Zhiwen Zhang, Lianyuan Yu, Xiaohan Shi, Suizhi Gao, Huan Wang, Yaqi Pan, Chengcheng Ma, Rui Liu, Menghua Dai, Gang Jin, Zhiyong Liang   +17 more
doaj   +1 more source

Preoperative detection of KRAS G12D mutation in ctDNA is a powerful predictor for early recurrence of resectable PDAC patients

British Journal of Cancer, 2020
About 25–37% of resectable pancreatic ductal adenocarcinoma (PDAC) had a great chance of early recurrence after radical resection, which is mainly due to preoperative micrometastasis.
Shiwei Guo, Xiaohan Shi, Jing Shen, Suizhi Gao, Huan Wang, S. Shen, Yaqi Pan, Bo Li, Xiongfei Xu, Z. Shao, G. Jin   +10 more
semanticscholar   +1 more source

Lipophilic statins inhibit YAP nuclear localization, co-activator activity and colony formation in pancreatic cancer cells and prevent the initial stages of pancreatic ductal adenocarcinoma in KrasG12D mice. [PDF]

, 2019
We examined the impact of statins on Yes-associated Protein (YAP) localization, phosphorylation and transcriptional activity in human and mouse pancreatic ductal adenocarcinoma (PDAC) cells.
Chang, Hui-Hua, Eibl, Guido, Hao, Fang, Rozengurt, Enrique, Sinnett-Smith, James, Wang, Jing, Xu, Qinhong, Yu, Shuo   +7 more
core   +2 more sources

Noninvasive Young's modulus visualization of fibrosis progression and delineation of pancreatic ductal adenocarcinoma (PDAC) tumors using Harmonic Motion Elastography (HME) in vivo

Theranostics, 2020
Background and aims: Poor specificity and predictive values of current cross-sectional radiological imaging methods in evaluation of pancreatic adenocarcinoma (PDAC) limit the clinical capability to accurately stage the tumor pre-operatively and provide ...
Alireza Nabavizadeh, T. Payen, A. Iuga, Irina R. Sagalovskiy, Deborah Desrouilleres, Niloufar Saharkhiz, Carmine F. Palermo, Stephen A. Sastra, P. Oberstein, V. Rosario, M. Kluger, B. Schrope, J. Chabot, K. Olive, E. Konofagou   +14 more
semanticscholar   +1 more source

Complex-based analysis of dysregulated cellular processes in cancer [PDF]

, 2014
Background: Differential expression analysis of (individual) genes is often used to study their roles in diseases. However, diseases such as cancer are a result of the combined effect of multiple genes.
Khanna, Kum Kum, Liu, Chao, Madhamshettiwar, Piyush B., Ragan, Mark A., Simpson, Peter T., Song, Sarah, Srihari, Sriganesh   +6 more
core   +1 more source

Enhanced release of ciliary extracellular vesicles suppresses cell migration and promotes cell aggregation

Cell Structure and Function
A primary cilium is a hair-like organelle that protrudes from the cell surface in many cell types. Growing evidence indicates that extracellular vesicles are released from primary cilia, and research is increasingly focused on defining the functions of ...
Tetsuhiro Hara, Ryota Nakazato, Kenji Shirakawa, Faryal Ijaz, Kenichiro Uemura, Shinya Takahashi, Koji Ikegami   +6 more
doaj   +1 more source

Microbiome in pancreatic cancer – What is new in 2024? [PDF]

Microbiota in Health and Disease
Despite great efforts to improve understanding and treatment of pancreatic cancer, mainly pancreatic ductal adenocarcinoma (PDAC), the outcome of this malignant disease today is still very poor.
E. Hohmann, C. Ammer-Herrmenau, C. Schulz, S. Sirtl   +3 more
doaj   +1 more source