Results 71 to 80 of about 85,787 (336)

Combination of serum human satellite RNA and miR-21-5p levels as a biomarker for pancreatic cancer

iScience, 2023
Summary: Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis due to the difficulty of its diagnosis. Because human satellite II (HSATII) RNA, a satellite repeat RNA, is highly and specifically expressed in human PDAC, the serum HSATII RNA level ...
Takahiro Seimiya, Tatsunori Suzuki, Takuma Iwata, Takahiro Kishikawa, Kazuma Sekiba, Chikako Shibata, Kazunaga Ishigaki, Hiroaki Fujiwara, Hiroki Oyama, Sachiko Kanai, Tatsuya Sato, Yousuke Nakai, Rei Ishibashi, Masaru Moriyama, Ryo Nakagawa, Hideaki Ijichi, Motoyuki Otsuka, Kazuhiko Koike   +17 more
doaj   +1 more source

Mutant SF3B1 promotes malignancy in PDAC

eLife, 2023
The splicing factor SF3B1 is recurrently mutated in various tumors, including pancreatic ductal adenocarcinoma (PDAC). The impact of the hotspot mutation SF3B1 K700E on the PDAC pathogenesis, however, remains elusive. Here, we demonstrate that Sf3b1 K700E
Simmler, Patrik, Ioannidi, Eleonora I, Mengis, Tamara, Marquart, Kim Fabiano, Asawa, Simran, Van-Lehmann, Kjong, Kahles, Andre, Thomas, Tinu, Schwerdel, Cornelia, Aceto, Nicola, Rätsch, Gunnar, Stoffel, Markus, Schwank, Gerald   +12 more
openaire   +5 more sources

Pancreatic Ductal Adenocarcinoma (PDAC): A Review of Recent Advancements Enabled by Artificial Intelligence

Cancers
Simple Summary Pancreatic Ductal Adenocarcinoma (PDAC) remains one of the deadliest forms of cancer, characterized by high rates of metastasis, late detection, and poor prognoses.
Ashwin Mukund, Muhammad Ali Afridi, Aleksandra Karolak, Margaret A Park, J. Permuth, Ghulam Rasool   +5 more
semanticscholar   +1 more source

Metformin Decreases the Incidence of Pancreatic Ductal Adenocarcinoma Promoted by Diet-induced Obesity in the Conditional KrasG12D Mouse Model. [PDF]

, 2018
Pancreatic ductal adenocarcinoma (PDAC) is a particularly deadly disease. Chronic conditions, including obesity and type-2 diabetes are risk factors, thus making PDAC amenable to preventive strategies.
Chang, Hui-Hua, Chou, Caroline Ei Ne, Dawson, David W, Eibl, Guido, French, Samuel, Hao, Fang, Hines, O Joe, Moro, Aune, Rozengurt, Enrique, Schmidt, Andrea I, Sinnett-Smith, James   +10 more
core   +2 more sources

Genetic ablation of the cystine transporter xCT in PDAC cells inhibits mTORC1, growth, survival and tumor formation via nutrient and oxidative stresses.

Cancer Research, 2019
Although chemoresistance remains a primary challenge in the treatment of pancreatic ductal adenocarcinoma (PDAC), exploiting oxidative stress might offer novel therapeutic clues.
Boutaina Daher, S. Parks, J. Durivault, Yann Cormerais, Hanane Baidarjad, É. Tambutté, J. Pouysségur, M. Vucetic   +7 more
semanticscholar   +1 more source

ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth [PDF]

, 2017
Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer death; identifying PDAC enablers may reveal potential therapeutic targets. Expression of the actomyosin regulatory ROCK1 and ROCK2 kinases increased with tumor progression in human and ...
Anderson, Kurt I., Helbig, Lena, Julian, Linda, Kadir, Shereen, Kalna, Gabriela, McGhee, Ewan J., Morton, Jennifer P., Mullin, Margaret, Olson, Michael F., Pinho, Andreia V., Rath, Nicola, Rooman, Ilse, Samuel, Michael S.   +12 more
core   +1 more source

Blocking circ_0013912 Suppressed Cell Growth, Migration and Invasion of Pancreatic Ductal Adenocarcinoma Cells in vitro and in vivo Partially Through Sponging miR-7-5p

Cancer Management and Research, 2020
Weisheng Guo,1 Lin Zhao,1 Guangya Wei,1 Peng Liu,1 Yu Zhang,1 Liran Fu2 1Department of Hepatobiliary Surgery, Henan Province Hospital of Traditional Chinese Medicine, The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine ...
Guo W, Zhao L, Wei G, Liu P, Zhang Y, Fu L   +5 more
doaj  

pH-Dependent Microenvironmental Ionic Signaling in Pancreatic Ductal Adenocarcinoma. [PDF]

Acta Physiol (Oxf)
ABSTRACT Aim Pancreatic ductal adenocarcinoma (PDAC) develops within a uniquely dynamic pH landscape shaped by substantial acid–base fluxes produced by the exocrine pancreas. Secretion of alkaline pancreatic juice, normally linked to digestion, produces intermittent acidifications of the pancreatic interstitium, which challenges epithelial and stromal ...
Schwab A, Rugi M, Swietach P, Błaszczak W, Novak I, Deshar G, Pedersen SF, Ialchina R, Sandelin A, Yao J, Reshkin SJ, Cardone RA, Carvalho TMA, Arcangeli A, Bouazzi R, D'Alessandro FN, Prevarskaya N, Audero MM, Ouadid-Ahidouch H, Schnipper J, Pardo LA, Shi X, Alves F, Mitręga J, Trauzold A, Hagelund SE, Panyi G, Cozzolino M, Löwik CMWG, Mezzanotte L, McMorrow R, Pahl A, Hechler T, Papacharisi E, Pla AF, Szabo I, Hofschröer V, Pethő Z.   +37 more
europepmc   +2 more sources

Differential and Joint Effects of Metformin and Statins on Overall Survival of Elderly Patients with Pancreatic Adenocarcinoma: A Large Population-Based Study. [PDF]

, 2017
Background: Published evidence indicates that individual use of metformin and statin is associated with reduced cancer mortality. However, their differential and joint effects on pancreatic cancer survival are inconclusive.Methods: We identified a large ...
Demissie, Kitaw, E, Jian-Yu, Graber, Judith M., Lin, Yong, Lu, Shou-En, Lu-Yao, Grace, Petersen, Gloria M., Rotter, David, Tan, Xiang-Lin, Zhang, Lanjing   +9 more
core   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source