Results 171 to 180 of about 2,405 (181)

Optimal stability of a highly conserved RNA G4 in PDCoV nsp8 supports viral proliferation

RNA
Porcine deltacoronavirus (PDCoV), an emerging enteropathogenic coronavirus, primarily causes diarrhea in piglets and has the potential for cross-species transmission to humans. The recent detection of PDCoV in Haitian children underscores the urgent need for developing antiviral therapeutic strategies.
Puxian Fang, Congbao Xie, Ting Cheng, Jingjing Sui, Yan Cheng, Tong Ding, Jiahui Guo, Yuhan Zhang, Liurong Fang, Dengguo Wei, Shaobo Xiao   +10 more
openaire   +2 more sources

[Prokaryotic expression and helicase activity analysis of PDCoV NSP13].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology
Porcine deltacoronavirus (PDCoV) is a major pathogen causing fatal diarrhea in suckling piglets, and there is currently a lack of effective vaccines and drugs to prevent and control the virus. The nonstructural protein 13 (NSP13) serves as a virus-coded helicase and is considered to be a crucial target for antiviral drugs, making it imperative to ...
Lihan, Tao, Chengcheng, Wu, Cui, Lin, Zhaofeng, Kang, Jianzhen, Huang   +4 more
openaire   +1 more source

An Inactivated PDCoV Vaccine Induces Robust Neutralizing Antibodies and Immune Protection in Pigs Lasting for Three Months

Microbial Pathogenesis
Porcine deltacoronavirus (PDCoV), a novel enteropathogenic coronavirus, causes diarrhea mainly in suckling piglets and has the potential to infect humans. Whereas, there is no commercially available vaccine which can effectively prevent this disease. In this study, to ascertain the duration of immune protection of inactivated PDCoV vaccine, suckling ...
Jizong Li, Liyuan Fan, Xin Yi
exaly   +3 more sources

A trivalent enteric coronaviruses inactivated vaccine provides effective protection against PEDV, TGEV, and PDCoV

Veterinary Microbiology
Porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), and porcine deltacoronavirus (PDCoV) are three major coronaviruses responsible for severe diarrhea and mortality in piglets. Co-infections of these pathogens are frequently present in clinical cases, which aggravate the clinical symptoms and cause substantial economic ...
Liyuan Fan, Xin Yi, Chunyan Zhong, Chuangye Yang, Ziyi Niu, Xiaofeng Xue, Wei Wang, Rongli Guo, Jiale Ma, Yinhe Zha, Jianhong Shu, Jizong Li, Bin Li   +12 more
openaire   +2 more sources

A novel PEDV-specific linear B-cell epitope evades cross-reactivity with TGEV and PDCoV

Veterinary Microbiology
The high incidence of swine enteric coronavirus co-infections necessitates highly specific diagnostic tools targeting key viral antigens, such as the porcine epidemic diarrhea virus (PEDV) nucleocapsid (N) protein. In this study, we generated monoclonal antibodies (mAbs) against the recombinant PEDV N protein and mapped a novel, highly conserved linear
Shulei Li, Linyi Bai, Xifang Zhu, Jingming Zhou, Yumei Chen, Hongliang Liu, Xiao Liu, Haili Wang, Enping Liu, Yanhua Qi, Aiping Wang   +10 more
openaire   +2 more sources

Mechanism of Selenomethionine Inhibiting of PDCoV Replication in LLC-PK1 Cells Based on STAT3/miR-125b-5p-1/HK2 Signaling

Frontiers in Immunology, 2022
Junliang Deng, Zhihua Ren
exaly  

Pathogenicity of Porcine Deltacoronavirus (PDCoV) Strain NH and Immunization of Pregnant Sows With an Inactivated PDCoV Vaccine Protects 5-Day-Old Neonatal Piglets From Virulent Challenge

Transboundary and Emerging Diseases, 2020
Liyan Cao
exaly  

Mucosal Immune Responses Induced by Oral Administration of Recombinant Lactococcus lactis Expressing the S1 Protein of PDCoV

Virology, 2023
Zhongwang Zhang, Zhongyuan Ma, Jianliang Lv   +2 more
exaly  

Cleavage of the Selective Autophagy Receptor NBR1 by the PDCoV Main Protease NSP5 Impairs Autophagic Degradation of the Viral Envelope Protein

Autophagy
Rui Luo, Aohan Guan
exaly  

Resveratrol Inhibits Pdcov Infection by Activating Sirt1 to Promote Interferon Production

Songqi Wang, Zhicheng Liu, Jingjing Nie, Yunzhi Qu, Chunhong Zhang, Jianfeng Zhang, Jin Chen, Liting Hou, Yu Lu, Haiyan Shen, Renwei Su   +10 more
openaire   +1 more source