Results 171 to 180 of about 2,664 (192)

Adenovirus-vectored PDCoV vaccines induce potent humoral and cellular immune responses in mice

Vaccine, 2023
Porcine deltacoronavirus (PDCoV) is a novel swine enteropathogenic coronavirus that causes severe watery diarrhea, vomiting, dehydration and high mortality in piglets, resulting in significant economic losses by the global pig industry. Recently, PDCoV has also shown the potential for cross-species transmission. However, there are currently few vaccine
Yonglu Wang, Xinsheng Liu
exaly   +3 more sources

Mucosal immune responses induced by oral administration of recombinant Lactococcus lactis expressing the S1 protein of PDCoV

Virology, 2023
Porcine deltacoronavirus is an evolving coronavirus that primarily infects the intestine and may lead to intestinal disease in piglets. Up to now, no commercial vaccination is readily accessible to protect against the spread of PDCoV. Lactococcus lactis has been shown to have good immune efficacy and safety and can be used as a genetically engineered ...
Yonglu Wang, Li Pan, Yongguang Zhang
exaly   +3 more sources

PEDV and PDCoV Pathogenesis: The Interplay Between Host Innate Immune Responses and Porcine Enteric Coronaviruses [PDF]

Frontiers in Veterinary Science, 2019
El virus enteropatógeno de la diarrea epidémica porcina (PEDV) y el deltacoronavirus porcino (PDCoV), miembros de la familia de los coronavirus, representan la mayoría de la diarrea acuosa letal en cerdos neonatos en la última década. Estos dos virus plantean importantes cargas económicas y de salud pública, incluso cuando ambos continúan surgiendo y ...
Samaporn Teeravechyan, Thanathom Chailangkarn, Anan Jongkaewwattana   +2 more
exaly   +4 more sources

Expression of codon-optimized PDCoV-RBD protein in baculovirus expression system and immunogenicity evaluation in mice

International Journal of Biological Macromolecules, 2023
Porcine deltacoronavirus (PDCoV) is a global epidemic enteropathogenic coronavirus that mainly infects piglets, and causes huge losses to the pig industry. However, there are still no commercial vaccines available for PDCoV prevention and controlment.
Nianxiang, Wang, Zi, Wang, Mengyao, Ma, Xinhao, Jia, Hang, Liu, Mengwei, Qian, Sijia, Lu, Yuqiang, Xiang, Zhanyong, Wei, Lanlan, Zheng   +9 more
openaire   +2 more sources

Design and biological evaluation of candidate drugs against zoonotic porcine deltacoronavirus (PDCoV)

Antiviral Research
Porcine deltacoronavirus (PDCoV) is an emerging swine enteric coronavirus with zoonotic potential. PDCoV spillovers were recently detected in Haitian children with acute undifferentiated febrile illness, underscoring the urgent need to develop anti-PDCoV therapeutics.
Junwei Zhou, Peng Sun, Yuanqing Wang, Yuting Shi, Chaoqun Chen, Wenwen Xiao, Runhui Qiu, Ting Cheng, Liurong Fang, Shaobo Xiao   +9 more
openaire   +2 more sources

Effective inhibition of PDCoV infection in chimeric APN gene-edited neonatal pigs

Journal of Virology
ABSTRACT Porcine deltacoronavirus (PDCoV), an emerging enteropathogenic coronavirus, is a serious threat to piglets and has zoonotic potential. Here, we aimed to further explore the role of aminopeptidase N (APN) as a receptor for PDCoV and test the inhibitory effect of a chimeric APN protein strategy ...
Jizong Li, Jian Zhou, Tianyi Zhang, Heyong Wu, Feng Li, Chunyun Qi, Liyuan Fan, Xuesong Yuan, Wei Wang, Rongli Guo, Baochao Fan, Xiaochun Tang, Daxin Pang, Hongsheng Ouyang, Zicong Xie, Bin Li   +15 more
openaire   +2 more sources

Phosphorylation of G3BP1 is involved in the regulation of PDCoV-induced inflammatory response

Veterinary Microbiology
Stress granules (SGs), the main component is GTPase-activating protein-binding protein 1 (G3BP1), which are assembled during viral infection and function to sequester host and viral mRNAs and proteins, are part of the antiviral responses. In this study, we found that porcine deltacoronavirus (PDCoV) infection induced stable formation of robust SGs in ...
Baotai, Zhang, Siyuan, Li, Zhuoqi, Chen, Liyuan, Fan, Wei, Wang, Rongli, Guo, Baochao, Fan, Jizong, Li, Bin, Li   +8 more
openaire   +2 more sources

Synthesis and pharmacodynamic evaluation of Dihydropteridone derivatives against PDCoV in vivo and in vitro

Bioorganic Chemistry
Porcine Delta Coronavirus (PDCoV) infection can induce serious dehydration, diarrhea and even death of piglets, which has caused huge losses to the breeding industry. PDCoV has been reported to have the potential for cross species transmission, and even reports of infecting humans have emerged.
Kai, Sun, Zhongmou, Zhang, Jiani, Xing, Shouye, Ma, Yongzhuang, Ge, Lu, Xia, Xiaoqiong, Diao, Yonghong, Li, Zhanyong, Wei, Zhenya, Wang   +9 more
openaire   +2 more sources

An inactivated PDCoV vaccine induces robust neutralizing antibodies and immune protection in pigs lasting for three months

Microbial Pathogenesis
Porcine deltacoronavirus (PDCoV), a novel enteropathogenic coronavirus, causes diarrhea mainly in suckling piglets and has the potential to infect humans. Whereas, there is no commercially available vaccine which can effectively prevent this disease. In this study, to ascertain the duration of immune protection of inactivated PDCoV vaccine, suckling ...
, Baochao Fan, Jizong Li
exaly   +3 more sources

[Prokaryotic expression and helicase activity analysis of PDCoV NSP13].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology
Porcine deltacoronavirus (PDCoV) is a major pathogen causing fatal diarrhea in suckling piglets, and there is currently a lack of effective vaccines and drugs to prevent and control the virus. The nonstructural protein 13 (NSP13) serves as a virus-coded helicase and is considered to be a crucial target for antiviral drugs, making it imperative to ...
Lihan, Tao, Chengcheng, Wu, Cui, Lin, Zhaofeng, Kang, Jianzhen, Huang   +4 more
openaire   +1 more source