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Porcine Deltacoronavirus (PDCoV) Infection Suppresses RIG-I-Mediated Interferon-β Production
Virology, 2016 Porcine deltacoronavirus (PDCoV), an emerging animal coronavirus causing enteric disease in pigs, belongs to the newly identified Deltacoronavirus genus in the Coronaviridae family. Although extensive studies have been carried out to investigate the regulation of interferon (IFN) responses by alphacoronaviruses, betacoronaviruses, and ...
Zhen Ding, Shaobo Xiao, Huanchun Chen
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Adenovirus-Vectored PDCoV Vaccines Induce Potent Humoral and Cellular Immune Responses in Mice
Vaccine, 2023Porcine deltacoronavirus (PDCoV) is a novel swine enteropathogenic coronavirus that causes severe watery diarrhea, vomiting, dehydration and high mortality in piglets, resulting in significant economic losses by the global pig industry. Recently, PDCoV has also shown the potential for cross-species transmission. However, there are currently few vaccine
Li Pan, Xinsheng Liu, Ruiming Yu
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International Immunopharmacology, 2022
The objective was to evaluate effects of niacin on the intestinal epithelial barrier, intestinal immunity, and microbial community in weaned piglets challenged by Porcine Deltacoronavirus (PDCoV). In this study, fifteen weaned piglets were randomly assigned to 1 of 3 groups, (1) control group, normal diet; (2) PDCoV group, infected with 1 × 107 TCID50 ...
Qiwen Wu, Junsen Feng, Yongsheng Xie
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The objective was to evaluate effects of niacin on the intestinal epithelial barrier, intestinal immunity, and microbial community in weaned piglets challenged by Porcine Deltacoronavirus (PDCoV). In this study, fifteen weaned piglets were randomly assigned to 1 of 3 groups, (1) control group, normal diet; (2) PDCoV group, infected with 1 × 107 TCID50 ...
Qiwen Wu, Junsen Feng, Yongsheng Xie
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Bioorganic Chemistry
Porcine Delta Coronavirus (PDCoV) infection can induce serious dehydration, diarrhea and even death of piglets, which has caused huge losses to the breeding industry. PDCoV has been reported to have the potential for cross species transmission, and even reports of infecting humans have emerged.
Lu Xia, Yonghong Li, Zhenya Wang
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Porcine Delta Coronavirus (PDCoV) infection can induce serious dehydration, diarrhea and even death of piglets, which has caused huge losses to the breeding industry. PDCoV has been reported to have the potential for cross species transmission, and even reports of infecting humans have emerged.
Lu Xia, Yonghong Li, Zhenya Wang
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Establishment and Application of a Dual Chip Digital PCR Assay for Detection of PDCoV and PEDV
Frontiers in Veterinary ScienceIntroductionCoinfection with porcine deltacoronavirus (PDCoV) and porcine epidemic diarrhea virus (PEDV) is a major cause of acute diarrhea in piglets, which poses a significant challenge to the swine industry. The early detection and control of these two viruses require highly sensitive diagnostic tools.
Lu Xia, Shaopo Zu
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PGAM5 Degrades PDCoV N Protein and Activates Type I Interferon to Antagonize Viral Replication.
Journal of Virology, 2023ABSTRACT In recent years, porcine deltacoronavirus (PDCoV) has become a new intestinal coronavirus in pigs, rapidly spreading across multiple countries and causing significant financial losses in the global pig industry. Currently, no effective commercial vaccine is available to prevent this virus’ spread.
Guangzhi Tong, Tongling Shan, Wen Zhang
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Phosphorylation of G3BP1 is involved in the regulation of PDCoV-induced inflammatory response
Veterinary MicrobiologyStress granules (SGs), the main component is GTPase-activating protein-binding protein 1 (G3BP1), which are assembled during viral infection and function to sequester host and viral mRNAs and proteins, are part of the antiviral responses. In this study, we found that porcine deltacoronavirus (PDCoV) infection induced stable formation of robust SGs in ...
Baotai, Zhang +8 more
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International Journal of Biological Macromolecules, 2023
Porcine deltacoronavirus (PDCoV) is a global epidemic enteropathogenic coronavirus that mainly infects piglets, and causes huge losses to the pig industry. However, there are still no commercial vaccines available for PDCoV prevention and controlment.
Nianxiang, Wang +9 more
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Porcine deltacoronavirus (PDCoV) is a global epidemic enteropathogenic coronavirus that mainly infects piglets, and causes huge losses to the pig industry. However, there are still no commercial vaccines available for PDCoV prevention and controlment.
Nianxiang, Wang +9 more
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Antiviral Research
Porcine deltacoronavirus (PDCoV) is an emerging swine enteric coronavirus with zoonotic potential. PDCoV spillovers were recently detected in Haitian children with acute undifferentiated febrile illness, underscoring the urgent need to develop anti-PDCoV therapeutics.
Junwei Zhou +9 more
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Porcine deltacoronavirus (PDCoV) is an emerging swine enteric coronavirus with zoonotic potential. PDCoV spillovers were recently detected in Haitian children with acute undifferentiated febrile illness, underscoring the urgent need to develop anti-PDCoV therapeutics.
Junwei Zhou +9 more
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Effective inhibition of PDCoV infection in chimeric APN gene-edited neonatal pigs
Journal of VirologyABSTRACT Porcine deltacoronavirus (PDCoV), an emerging enteropathogenic coronavirus, is a serious threat to piglets and has zoonotic potential. Here, we aimed to further explore the role of aminopeptidase N (APN) as a receptor for PDCoV and test the inhibitory effect of a chimeric APN protein strategy ...
Jizong Li +15 more
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