Results 91 to 100 of about 8,073 (209)
Медицинский совет, 2014 Phosphodiesterase type 5 (PDE5) inhibitors modulate afferent nerve activity, increase nitric oxide activity resulting in the corpus cavernosal smooth muscle relaxation in the penis, prostate, urethra and bladder neck.
AV Govorov +3 more
doaj +1 more source
Sexual Medicine, 2014 Introduction: The high effectiveness of phosphodiesterase type 5 inhibitors (PDE5-i) in the treatment of erectile dysfunction (ED) has been demonstrated. However, previous research shows that PDE5-i treatments have high discontinuation rates.
Ana Carvalheira, PhD +2 more
doaj +1 more source
Treatment Strategy for Non-Responders to PDE5 Inhibitors
The World Journal of Men's Health, 2013 Currently, phosphodiesterase type 5 (PDE5) inhibitors are the initial treatment option for erectile dysfunction. The reported efficacy of PDE5 inhibitors is about 70%, although it is significantly lower in difficult-to-treat subpopulations. Treatment failures might be due to the severity of the underlying pathophysiology, improper use of medication ...
Park, Nam Cheol +2 more
openaire +2 more sources
Expression of the PDE5 enzyme on human retinal tissue: new aspects of PDE5 inhibitors ocular side effects [PDF]
, 2008 OBJECTIVE: We tested the effect of two phosphodiesterase type-5 (PDE5) inhibitors, sildenafil and tadalafil, on ophthalmic artery (OA) blood flow velocity and investigated the presence of the PDE5 enzyme on human retinal tissue in comparison with the ...
FORESTA, CARLO +6 more
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Biopiperazines-bridged analogs of piperazine-and their application in PDE5 Inhibitors [PDF]
, 2009 Diese Arbeit betrifft die Herstellung von einigen gebrueckten Analogen von Piperazin und die Einfuehrung von solchen geaenderten Piperazinanalogen in die molekuelaren Gerueste von bekannten Pharmazeutika zur Erzeugung neuer Analoge von PDE5-Inhibitoren ...
Lightner, Derek Alton
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Hyperprolactinemia contributes to reproductive deficit in male rats chronically administered PDE5 inhibitors (sildenafil and tadalafil) and opioid (tramadol) [PDF]
, 2016 Objectives: To examine the influence of prolonged use of PDE5 inhibitors and opioids on prolactin among other male reproductive hormones, on the background that hyperprolactinemia has recently been associated with male sterility.
V.U. Nna, U.P. Akpan, E.E. Osim
core +1 more source
Communications BiologyPhosphodiesterase-5 (PDE5) inhibitors have shown promise as anti-cancer agents in malignancies. However, their specific effects on gastric cancer (GC) and the underlying mechanisms remain elusive.
Zhenzhan Zhang +10 more
doaj +1 more source
CellsPhosphodiesterases, particularly the type 5 isoform (PDE5), have gained recognition as pivotal regulators of male reproductive physiology, exerting significant influence on testicular function, sperm maturation, and overall fertility potential.
Aris Kaltsas +4 more
doaj +1 more source
Melanoma, Viagra, and PDE5 Inhibitors: Proliferation and Metastasis [PDF]
Trends in Cancer, 2016 Inhibitors of the cGMP-degrading phosphodiesterase (PDE) 5 have achieved blockbuster status in the treatment of penile erectile dysfunction (PED). Their repurposing is currently being proposed to treat certain solid tumours and various other diseases. In cruel irony, however, it appears from recent clinical studies that PDE5 inhibitors may increase the
openaire +3 more sources
A survey on the experience of 136 Italian urologists in the treatment of erectile dysfunction with PDE5 inhibitors and recommendations for the use of Avanafil in the clinical practice [PDF]
, 2016 Introduction: PDE5 inhibitors are the firstline treatment for erectile dysfunction. Although all these drugs share the same mechanism of action, each agent could have different characteristics in terms of selectivity, pharmacokinetics and tolerability ...
Parazzini F +7 more
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