Results 71 to 80 of about 8,073 (209)

Ejaculatory Dysfunction and Minimally Invasive Surgical Treatments (MIST) for Male Lower Urinary Tract Symptoms Secondary to Benign Prostatic Enlargement

Trends in Urology &Men's Health, Volume 17, Issue 4, August 2026.
ABSTRACT While transurethral resection of the prostate (TURP) is considered the standard surgical treatment in symptomatic benign prostatic enlargement (BPE) secondary to benign prostatic hyperplasia (BPH), it is not without surgical morbidities and has adverse impact on various sexual function domains such as ejaculatory dysfunction (EjD) and erectile
Haijun Yao, Tao Wang, Shan‐Chao Zhao, Lei Zheng, Rui Jiang, Han Wu, Jingjing Gao, Baibing Yang, Yuzhuo Yang, Haocheng Lin, Eric Chung   +10 more
wiley   +1 more source

Cardiovascular implications in the use of PDE5 inhibitor therapy [PDF]

International Journal of Impotence Research, 2004
Cardiovascular smooth muscle cells (SMCs) exist as resting or activated cells. Resting SMCs produce contractile proteins and are nearly transcriptionally inactive; activated SMCs are transcriptionally active and are involved in pathological processes such as atherosclerosis.
openaire   +2 more sources

Effects of phosphodiesterase type 5 inhibitors on choroid and ocular vasculature: a literature review

International Journal of Retina and Vitreous, 2020
To provide information on the effects of phosphodiesterase type 5 (PDE5) inhibitors on choroidal vessels and central serous chorioretinopathy (CSC) and possible implications for development of exudative age-related macular degeneration (AMD).
Natasha Ferreira Santos da Cruz, Murilo Ubukata Polizelli, Laís Maia Cezar, Emmerson B. Cardoso, Fernando Penha, Michel Eid Farah, Eduardo B. Rodrigues, Eduardo A. Novais   +7 more
doaj   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Discovery of Natural Phosphodiesterase 5 Inhibitors from Dalbergia cochinchinensis Pierre Leaves Using LC-QTOF-MS²

Plants
The imbalance of phosphodiesterase 5 (PDE5) enzyme in the male body, or excessive PDE5 enzyme levels, can occur due to factors such as aging, diseases (e.g., cardiovascular disease, diabetes, depressive disorder), and physical behaviors (e.g., alcoholism,
Ruttanaporn Chantakul, Corine Girard, François Senejoux, Kornkanok Ingkaninan, Nitra Nuengchamnong, Prapapan Temkitthawon   +5 more
doaj   +1 more source

Circadian‐Related Serotonin/Melatonin Level Modulates Cisplatin Ototoxicity Susceptibility Depended on NOS3–NO Pathway

Journal of Pineal Research, Volume 78, Issue 4, July 2026.
ABSTRACT Hearing impairment is attributed to factors such as age, genetic predisposition, and environmental influences, among which environmental factors are considered modifiable. Among various environmental factors, the role of poor lifestyle habits is particularly critical, yet the specific mechanisms by which they contribute to hearing damage ...
Siyu Qiu, Shiyi Cai, Rong Xie, Chang Liu, Yingzi He   +4 more
wiley   +1 more source

Membrane-Mediated Action of Phosphodiesterase 5 Inhibitors

Pharmaceutics
Background/Objectives: Phosphodiesterase 5 (PDE5) inhibitors, sildenafil, vardenafil, and tadalafil, activate the cyclic guanosine monophosphate pathway resulting in vascular smooth muscle relaxation.
Anna I. Malykhina, Svetlana S. Efimova, Olga S. Ostroumova   +2 more
doaj   +1 more source

Real‐World Long‐Term Outcomes of Rezūm Therapy for Large‐Volume Benign Prostatic Hyperplasia: A Multicenter Cohort Study

LUTS: Lower Urinary Tract Symptoms, Volume 18, Issue 4, July 2026.
ABSTRACT Objectives Benign prostatic hyperplasia (BPH) is a common cause of lower urinary tract symptoms (LUTS) in aging men. Patients with large prostates (≥ 80 mL) often experience more severe symptoms and have limited minimally invasive treatment options.
Liberty Liu, Mario Henrique Bitar Siqueira, Naeem Bhojani, Bilal Chughtai, Kevin C. Zorn, Luca Cindolo, Giovanni Ferrari, Katherine Lajkosz, Eviatar Fields, Dean Elterman   +9 more
wiley   +1 more source

Survival Improvement With Steroid Use for Pulmonary Veno‐Occlusive Disease With the Aid of Pulmonary Vasodilators and Tyrosine‐Kinase Inhibitor, a Retrospective Study

Clinical Cardiology, Volume 49, Issue 6, June 2026.
This study aimed to assess the efficacy of steroid treatment with pulmonary vasodilators and tyrosine kinase inhibitors in patients with Pulmonary VenoOcclusive Disease (PVOD). Kaplan‐Meier curve showed that survival of PVOD patients with PSL (PRS) was significantly better with Log rank test (p = 0.01) than without PSL (PNS).
Mayumi Finger, Kaori Takeuchi, Hanako Kikuchi, Ayumi Goda, Takumi Inami, Yuichi Tamura, Masaharu Kataoka, Toru Satoh   +7 more
wiley   +1 more source

PDE5 expression in human thyroid tumors and effects of PDE5 inhibitors on growth and migration of cancer cells [PDF]

, 2015
Recent studies have revealed in normal thyroid tissue the presence of the transcript of several phosphodiesterases (PDEs), enzymes responsible for the hydrolysis of cyclic nucleotides. In this work, we analyzed the expression of PDE5 in a series of human
Russo D, GIACOMELLI, Laura, Damante G, De Rose, Roberta Francesca, Maggisano, Valentina, VERRIENTI, Antonella, Celano M., Maggisano V, Bulotta S, Russo, Diego, De Rose RF, ROSIGNOLO, FRANCESCA, Damante, Giuseppe, Celano, Marilena, Bulotta, Stefania, FILETTI, SEBASTIANO, PECCE, VALERIA, SPONZIELLO, Marialuisa, DURANTE, COSIMO, DI GIOIA, Cira Rosaria Tiziana   +19 more
core   +1 more source