Results 61 to 70 of about 12,266 (204)

Supersonic transporter (SST) deformity of penile prosthesis: Current management strategies

UroPrecision, EarlyView.
Abstract Supersonic transporter (SST) deformity, also known as floppy glans syndrome, represents a persistent source of post‐operative dissatisfaction among patients undergoing inflatable penile prosthesis (IPP) implantation. Although infection and mechanical failure rates have declined with advances in device design and surgical technique, SST ...
Mohammed Mahdi, Thairo A. Pereira, Muhammed A. M. Hammad   +2 more
wiley   +1 more source

PDE5 Inhibitors As Potential Tools In The Treatment Of Cystic Fibrosis

Frontiers in Pharmacology, 2012
Despite great advances in the understanding of the genetics and pathophysiology of cystic fibrosis (CF), there is still no cure for the disease. Using phosphodiesterase type 5 (PDE5) inhibitors, we and others have provided evidence of rescued F508del ...
Sabrina eNoel, Barbara eDhooghe, Teresinha eLeal   +2 more
doaj   +1 more source

Structural Determination, Biological Function, and Molecular Modelling Studies of Sulfoaildenafil Adulterated in Herbal Dietary Supplement

Molecules, 2021
Unapproved ingredients included in herbal medicines and dietary supplements have been detected as adulterated synthetic drugs used for erectile dysfunction. Extraction from a dietary supplement was performed to isolate the compounds by HPLC analysis. The
Kanchanok Kodchakorn, Nawarat Viriyakhasem, Tunchanok Wongwichai, Prachya Kongtawelert   +3 more
doaj   +1 more source

Upregulation of Phosphodiesterase type 5 in the Hyperplastic Prostate [PDF]

, 2015
Both erectile dysfunction (ED) and lower urinary tract symptoms (LUTS)/benign prostatic hyperplasia (BPH) are common in the aging male. Numerous clinical trials have demonstrated the efficacy and safety of phosphodiesterase type 5 inhibitors (PDE5-Is ...
Chen, P. (Ping), Jiang, Y. (Yaoming), Wang, X. (Xinghuan), Zang, N. (Ning), Zhang, W. (Wenhao), Zhang, X. (Xinhua)   +5 more
core   +1 more source

Penile rehabilitation in men after radical robotic prostatectomy: Fact or fiction?

UroPrecision, EarlyView.
Abstract Erectile dysfunction (ED) is one of the most frequent and distressing complications after radical prostatectomy (RP), significantly impairing patients’ quality of life and intimate relationships. Penile rehabilitation (PR) aims to preserve erectile tissue integrity, prevent fibrosis, and facilitate early functional recovery by restoring ...
Karen Zhang, Arnold P. P. Achermann, Hunter Hasley, Richard Bennett, Andrew Guo, Mohammed Mahdi, Lucas G. C. R. de Amorim, Helen L. Bernie, Thairo A. Pereira   +8 more
wiley   +1 more source

Penile vibratory stimulation in the recovery of urinary continence and erectile function after nerve‐sparing radical prostatectomy: a randomized, controlled trial [PDF]

, 2014
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/107551/1/bju12501 ...
Aydogdu, Brackett, Burnett, Campbell, Farag, Fode, Giuliano, Hammerer, Iacono, Klein, Kohler, Laessoe, Laessoe, Masterson, Miles, Montorsi, Montorsi, Padma-Nathan, Penson, Raina, Reitz, Rosen, Salonia, Schou, Schraffordt, Schwartz, Shafik, Sonksen, Sonksen, Sonksen, Tal, Teloken, User, Walsh, Yokoyama   +34 more
core   +2 more sources

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

PDE5 inhibitors against cancer via mediating immune cells in tumor microenvironment: AI‐based approach for future drug repurposing exploration

Interdisciplinary Medicine
Phosphodiesterase‐5 (PDE5) inhibitors are used clinically for the treatment of erectile dysfunction, pulmonary arterial hypertension, and other urological diseases.
Zhenzhan Zhang, Donghua Huang, Junjie Feng, Wangji Li, Zhe Wang, Mengting Lu, Yangyang Luo, Weihao Yang, Zhou Xu, Qingfeng Xie, Wenfu Ding, Xin Tan, Wenjun He, Guoxin Li, Hao Liu, Shangtong Lei   +15 more
doaj   +1 more source

Discovery of Natural Phosphodiesterase 5 Inhibitors from Dalbergia cochinchinensis Pierre Leaves Using LC-QTOF-MS²

Plants
The imbalance of phosphodiesterase 5 (PDE5) enzyme in the male body, or excessive PDE5 enzyme levels, can occur due to factors such as aging, diseases (e.g., cardiovascular disease, diabetes, depressive disorder), and physical behaviors (e.g., alcoholism,
Ruttanaporn Chantakul, Corine Girard, François Senejoux, Kornkanok Ingkaninan, Nitra Nuengchamnong, Prapapan Temkitthawon   +5 more
doaj   +1 more source

Exploration of icariin analog structure space reveals key features driving potent inhibition of human phosphodiesterase-5.

PLoS ONE, 2019
The natural product icariin inhibits human phosphodiesterase-5 (PDE5) and represents a unique pharmacophore for treating erectile dysfunction, pulmonary hypertension, and other diseases.
Yasmin Chau, Fu-Shuang Li, Olesya Levsh, Jing-Ke Weng   +3 more
doaj   +1 more source