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Letter Written by Mrs. W. H. Peach to the Bryant College Service Club Dated July 20, 1944 [PDF]

, 1944
[Transcription begins] July 20, 1944 [postmark date] Gentlemen: Howard I. Peach of Bryant 1942 has a new A.P.O. - No., and I tho’t you might want it for your records. He has been in England about 4 months and is O.K.
Peach, Mrs. W. H.
core  

Chemoproteomic discovery of a brain‐penetrant, covalent NLRP3 inhibitor that binds a novel allosteric pocket

British Journal of Pharmacology, EarlyView.
NLRP3 is a promising inflammatory target, but existing inhibitors lack diversity and brain penetrance, and none are approved. Using chemoproteomics, we discovered a novel series that binds to Cys463 in a previously uncharacterized pocket. Compounds showed nanomolar potency, brain exposure, and in vivo suppression of IL‐1β, supporting neuroinflammatory ...
Donald C. Rogness, Evelyn P. Sievert, Vincent F. Vartabedian, Steffen M. Bernard, Erick Aitchison, William Tao, Mikaela Lindvall, Jing Qian, Christie L. Eissler, Brian E. Nordin, Benjamin D. Horning, Cian Kingston, Kelsey N. Lamb, Joshua C. Bell, Bingwen Lu, Jonathan Pollock, Jun Shi, Roli Khattri, David S. Weinstein, Matthew P. Patricelli, Brian N. Cook, Gabriel M. Simon   +21 more
wiley   +1 more source

Nitrato de amônio e nitrato de potássio no desenvolvimento in vitro de embriões somáticos de pupunheiras Ammonium nitrate and potassium nitrate on in vitro peach palm somatic embryos development

Ciência Rural, 2010
A pupunheira tem se mostrado boa alternativa à exploração extrativista de espécies como juçara e açaí. Porém, quando produzida via sementes apresenta plantio heterogêneo, o que torna a micropropagação ótima alternativa para seu cultivo em larga escala. O
Thaís Lobo dos Santos, Cristina Vieira de Almeida, Gilvano Ebling Brondani, Marcílio de Almeida   +3 more
doaj   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, EarlyView.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

Alamandine/MrgD pathway modulates gut–bone marrow axis in ageing

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Ageing is associated with colon epithelial barrier disruption and up‐regulation of myelopoiesis in the bone marrow (BM). Alamandine (Ala) and MrgD are novel members of the renin angiotensin system (RAS). This study tested the hypothesis that Ala restores the colon epithelial barrier integrity in ageing via modulating gut–
Kishore Chittimalli, Henryata E. Rozario, Victor Martinez, Zachary L. McAdams, Stephen A. Adkins, Aaron C. Ericsson, Yagna P. R. Jarajapu   +6 more
wiley   +1 more source

Positive modulation of glucagon‐like peptide 1 (GLP‐1) receptor by endogenous haemorphins with implications in glucose metabolism and diabetes

British Journal of Pharmacology, EarlyView.
Haemorphins act on GLP‐1 receptor (GLP‐1R) activity and signalling in a positive allosteric manner. This leads to potentiated GLP‐1‐mediated activity and signalling, as well as insulin synthesis, which may have implications for glucose metabolism and, thereby, diabetes and obesity. (The graph was created in BioRender.com).
Farheen Badrealam Khan, Rwdah Mohamed Alameri, Yasir S. Raouf, Damien Maurel, Naiem Ahmad Wani, Anatoliy Shmygol, Irfa Anwar, Heng B. See, Elizabeth K. M. Johnstone, Elodie Dupuis, Eric Trinquet, Kevin D. G. Pfleger, Emilia Oueis, Mohammed Akli Ayoub   +13 more
wiley   +1 more source

Internet Key Exchange Protocol Fuzzing Test On Extended Peach Framework [PDF]

Proceedings of the 2016 International Conference on Artificial Intelligence and Engineering Applications, 2016
Yijie Shi, Jiawei Zhang
openaire   +1 more source

Additional file 1: of Effect of physical exercise training in patients with Chagas heart disease: study protocol for a randomized controlled trial (PEACH study)

, 2016
SPIRIT checklist. (DOC 121 kb)
Mendes, Fernanda de Souza Nogueira Sardinha, Sousa, Andréa Silvestre, Souza, Fernando Cesar de Castro, Pinto, Vivian Liane Mattos, Silva, Paula Simplicio, Saraiva, Roberto Magalhães, Salles Xavier, Sergio, Veloso, Henrique Horta, Holanda, Marcelo, Costa, Andréa, Carneiro, Fernanda Martins, Silva, Gilberto, Borges, Juliana Pereira, Tibirica, Eduardo, Olmo Pinheiro, Roberta, Lara, Flávio Alves, Hasslocher-Moreno, Alejandro Marcel, Brasil, Pedro, Felippe Felix Mediano, Mauro   +18 more
openaire   +1 more source

Procalcitonin to guide antibiotic use during the first wave of COVID-19 in English and Welsh hospitals: integration and triangulation of findings from quantitative and qualitative sources

BMJ Open
Aim To integrate the quantitative and qualitative data collected as part of the PEACH (Procalcitonin: Evaluation of Antibiotic use in COVID-19 Hospitalised patients) study, which evaluated whether procalcitonin (PCT) testing should be used to guide ...
Neil Powell, Emma Thomas-Jones, Paul Dark, Tamas Szakmany, Susan Hopkins, Jonathan Sandoe, Margaret Ogden, Robert M West, Enitan Carrol, Lucy Brookes-Howell, Philip Pallmann, Bethany Shinkins, Dominick Shaw, Philip Howard, Stacy Todd, Thomas P Hellyer, David G Partridge, Mahableshwar Albur, Martin Llewelyn, Helena K Parsons, Detelina Grozeva, Joanne Euden, Iain J McCullagh, Josie Henley, Wakunyambo Maboshe, Stuart E Bond   +25 more
doaj   +1 more source

Un/Learning Adult Frames of Reference in Death Enquiries: Thinking~With a Picturebook, Philosophical Animism and Ontological Tact

Children &Society, EarlyView.
ABSTRACT Developmental psychology continues to shape how adults engage with children about death and dying. This influences whether children are included in rituals surrounding human and other‐than‐human bodies. Figurations of the innocent, immature and vulnerable child still dominate adult imaginaries of young children's understandings of mortality ...
Karin Murris, Joanna Haynes, Joanne Peers   +2 more
wiley   +1 more source