Results 81 to 90 of about 1,254,632 (219)

Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes, Florian Buehning, Tobias Lerchner, Julia Vogel, Raluca I. Mincu, Matthias Totzeck, Tienush Rassaf, Lars Michel   +7 more
wiley   +1 more source

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

Cell-based assay for recruitment of DDR1 to collagen-coated beads [PDF]

, 2019
The discoidin domain receptors, DDR1 and DDR2, are key signaling receptors for the extracellular matrix protein collagen. The interactions of cells with collagen are difficult to study because of the difficulty to obtain native collagen fibers for in ...
Leitinger, Birgit, Juskaite, Victoria
core   +1 more source

Effect of plant growth regulators and type of media on multiplication and rooting of peach rootstock (Prunus persica L.) Garnem In vitro

Kufa Journal for Agricultural Sciences
Experiments were conducted in one of the private laboratories of Al-Fahama / Baghdad for August 2020 to June 2022 period. This study aimed to achieve an appropriate protocol for propagation the roortstock of peach Garnem (Prunus persica cv.
Sarah Ali Muhammad Al-Hayani
doaj   +1 more source

A fast and efficient protocol for small RNA extraction in Japanese plum and other Prunus species

Electronic Journal of Biotechnology, 2017
Background: Small ribonucleic acids represent an important repertoire of mobile molecules that exert key roles in several cell processes including antiviral defense.
Evelyn Sánchez, David Tricon, Roxana Mora, Daniela Quiroz, Véronique Decroocq, Humberto Prieto   +5 more
doaj   +1 more source

Efficacy of Traditional Chinese Medicine, Maxingshigan-Weijing in the management of COVID-19 patients with severe acute respiratory syndrome: A structured summary of a study protocol for a randomized controlled trial

Trials, 2020
Objectives We aimed to test our expectation that additional administration of Traditional Chinese medicine (TCM), maxingshigan-weijing decoction, is more effective in the management of COVID-19 patients compared to those treated with routine supportive ...
Congcong Zeng, Zhengzhong Yuan, Xiaoqiong Pan, Jizhou Zhang, Jiahui Zhu, Fan Zhou, Zhuocheng Shan, Ye Yuan, Ren Ye, Jinguo Cheng   +9 more
doaj   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Augmented analysis of sensorial, volatilome and gene expression data from peach cultivars during cold storage to identify markers for fruit quality

, 2022
Peach (Prunus persica (L. Batsch) produces high quality but perishable fruit appreciated for their distinctive aroma, and other organoleptic qualities including sweetness, colour, and texture which vary across different cultivars.
Antonella Muto, Damiana Spadafora, Hilary Rogers, Leonardo Bruno, Innocenzo Muzzalupo, Adriana Chiappetta, Carsten Muller, Maria Beatrice Bitonti, Ernesto Picardi, Antonio Ferrante   +9 more
core  

Solubilization Method for Isolation of Photosynthetic Mega- and Super-complexes from Conifer Thylakoids

, 2021
Photosynthesis is the main process by which sunlight is harvested and converted into chemical energy and has been a focal point of fundamental research in plant biology for decades.
Bag, Pushan,, Farci, Domenica,, Jansson, Stefan, Schröder, Wolfgang P.,, Farci, Domenica, Jansson, Stefan,, Bag, Pushan, Schröder, Wolfgang P.   +7 more
core   +1 more source

Subregion‐specific perineuronal net remodelling in the dorsal hippocampus drives vulnerability and resilience to chronic stress: The role of venlafaxine treatment

British Journal of Pharmacology, EarlyView.
Background and Purpose Neuronal plasticity enables the brain to adapt to internal and external demands by dynamically regulating synaptic connectivity and emotional circuitry. Impaired neuroplasticity represents a core pathophysiological framework of major depressive disorder, one of the leading causes of disability worldwide. Chronic stress is a major
Paola Brivio, Arianna Palumbo, Maria Teresa Gallo, Filippo Umberto Tancredi Veronesi, Giorgia Cortinovis, Piotr Gruca, Magdalena Lason, Ewa Litwa, Dominika Biala, Fabio Fumagalli, Mariusz Papp, Francesca Calabrese   +11 more
wiley   +1 more source