Results 141 to 150 of about 17,231 (296)

Peaches in Shipping Containers

, 2007
Peaches in shipping ...

core  

Chemoproteomic discovery of a brain‐penetrant, covalent NLRP3 inhibitor that binds a novel allosteric pocket

British Journal of Pharmacology, EarlyView.
NLRP3 is a promising inflammatory target, but existing inhibitors lack diversity and brain penetrance, and none are approved. Using chemoproteomics, we discovered a novel series that binds to Cys463 in a previously uncharacterized pocket. Compounds showed nanomolar potency, brain exposure, and in vivo suppression of IL‐1β, supporting neuroinflammatory ...
Donald C. Rogness, Evelyn P. Sievert, Vincent F. Vartabedian, Steffen M. Bernard, Erick Aitchison, William Tao, Mikaela Lindvall, Jing Qian, Christie L. Eissler, Brian E. Nordin, Benjamin D. Horning, Cian Kingston, Kelsey N. Lamb, Joshua C. Bell, Bingwen Lu, Jonathan Pollock, Jun Shi, Roli Khattri, David S. Weinstein, Matthew P. Patricelli, Brian N. Cook, Gabriel M. Simon   +21 more
wiley   +1 more source

Evaluating PEACHES: Pleasure-Inclusive Implementation Strategies to Enable Healthcare Workers to Address Anal Sex Stigma During HIV Service Encounters. [PDF]

Arch Sex Behav
Kutner BA, Huang LJ, Rinnooy Kan CE, Hou B, Xu Y, Giguere R, Pickett J, Wharton MJ, Bowen-Lasisi S, Quintero E, Mowrey WB, Sandfort TGM, members of The Pleasure, Health Study Advisory Board.   +13 more
europepmc   +1 more source

Long non‐coding RNAs at the crossroads of inflammation, cancer and angiogenesis: Molecular mechanisms and their potential as therapeutic targets

British Journal of Pharmacology, EarlyView.
Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff, Pamela Calle‐Mendoza, Maria Hatziapostolou, Christos Polytarchou   +3 more
wiley   +1 more source

FAIR by design (TRACE): A Trusted Research Access & Collaboration Environment. [PDF]

BMC Med Inform Decis Mak
Müller M, Geisler BP, Shamas S, Bomhard NV, Hoster E, Pfirrmann M, Mansmann U.   +6 more
europepmc   +1 more source

Farmer's Pride Peaches

, 1930
A bowl of Farmer's Pride peaches has been put out in a dark glass bowl on an embroidered doily. They are canned peaches and appear to have been packed in syrup.This image is a preservation copy made from an unstable original nitrate ...
Martin's Photo Shop
core  

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, EarlyView.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

A Bounty of Peaches

The image shows a basket filled with juicy, ripe peaches of the Hale variety. The peaches are a vibrant peachy-orange color, some with a slight blush. The basket is woven from natural materials and is surrounded by lush green leaves, creating a rustic ...

core   +1 more source

Dual regulation of anthocyanins and proanthocyanidins by PpBL and its linkage to acidity in peach. [PDF]

Mol Hortic
Xing H, Fan J, Li G, Cao K, Li Y, Zhu G, Fang W, Chen C, Wang X, Wu J, Wang L.   +10 more
europepmc   +1 more source

Alamandine/MrgD pathway modulates gut–bone marrow axis in ageing

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Ageing is associated with colon epithelial barrier disruption and up‐regulation of myelopoiesis in the bone marrow (BM). Alamandine (Ala) and MrgD are novel members of the renin angiotensin system (RAS). This study tested the hypothesis that Ala restores the colon epithelial barrier integrity in ageing via modulating gut–
Kishore Chittimalli, Henryata E. Rozario, Victor Martinez, Zachary L. McAdams, Stephen A. Adkins, Aaron C. Ericsson, Yagna P. R. Jarajapu   +6 more
wiley   +1 more source