Results 31 to 40 of about 16,799 (303)

Bioorthogonal Fluorogenic Reporters for Noninvasive Imaging and Urinalysis of Immunotherapeutic Response in Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reported renal‐clearable bio‐orthogonal near‐infrared fluorogenic probes (BGRs) that specifically imaging and urinalysis of granzyme B for dynamic evaluation of RCC immunotherapy. BGRs not only differentiate immunotherapeutic responses in orthotopic RCC mice, but also enable sensitive optical urinalysis of granzyme B in clinical specimens ...
Xingyue Yang, Baoshuai Liang, Liangmin Fu, Weiliang Deng, Yuyan Jiang, Weiping Xu, Jinwei Chen, Ya Zhou, Ke Wu, Jiaguo Huang   +9 more
wiley   +1 more source

The regulatory roles of choline in the immune response induced by LPS and transplantation in pearl oysters Pinctada fucata martensii

Aquaculture Reports
Choline (Cho) plays a pivotal role in cellular and organismal homeostasis. In this study, transcriptome and serum immune indicator analysis were used to focus on the immune regulatory roles of Cho in the LPS and transplantation induced immune responses ...
Guixuan Chen, Hongxi Chen, Zhihao Chen, Ming Zhang, Yu Jiao, Qingheng Wang, Chuangye Yang, Yuewen Deng   +7 more
doaj   +1 more source

A Non‐Canonical Role of SMAD4 in Regulating 3D Genome Architecture to Inhibit Lung Squamous Cell Carcinoma Development

Advanced Science, EarlyView.
SMAD4 is identified as a guardian of 3D genome architecture in lung squamous cell carcinoma. Loss of SMAD4 unleashes EP300 at chromatin loop anchors, strengthening enhancer–promoter looping and H3K27ac at the SOX2 locus to drive aberrant SOX2 activation and tumor cell proliferation.
Qian Tang, Chen Lian, Xinyan Han, Xuhan Zhang, Zihan Wang, Boyu Wang, Taoyu Zhu, Xinrui Lin, Xiaolei Wang, Yaping Xu, Manyu Xiao, Zijin Wang, Junming Li, Silin Chen, Yunze Wang, Yufei Liu, Songsong Li, Zuolin Shen, Xi Lu, Xueqi Han, Yilu Zhou, Mingyang Xiao, Jiayi Ran, Xiaoran Cao, Xinyi Xu, Hugo Sámano‐Sánchez, Alfredo Rodríguez, Lian Wang, Shuifang Chen, Zhanyu Xu, Shirong Zhang, Nuo Yang, Yong Tang, Jian Liu   +33 more
wiley   +1 more source

Transcriptome analysis reveals the transition and crosslinking of immune response and biomineralization in shell damage repair in pearl oyster

Aquaculture Reports, 2021
The exoskeleton outside the soft body in shelled Mollusca defends against physical damage and parasite invasion and frequently undergoes biological and abiotic disturbance in natural and farmed environments, causing shell damage and environmental ...
Xinwei Xiong, Yanfei Cao, Zhixin Li, Yu Jiao, Xiaodong Du, Zhe Zheng   +5 more
doaj   +1 more source

NMI Regulates Adipose Adaptive Thermogenesis Through TLR4/IRF3 Signaling to Promote Obesity

Advanced Science, EarlyView.
Adipose tissue‐derived NMI is secreted under metabolic stress and suppresses adaptive thermogenesis through TLR4/IRF3 signaling, repressing the PPARα/PGC‐1α/UCP1 thermogenic transcriptional program. Genetic ablation or anti ‐ NMI monoclonal antibody treatment enhances energy expenditure, protects against DIO, and ameliorates adipose tissue inflammation,
Ting‐Ting Li, Xin‐Yuan Zhao, Min Zhang, Zhuang‐Feng Weng, Xiao‐Ran Guo, Ying‐Fang Liu, Qiao‐Ping Wang, Huan‐Huan Liang   +7 more
wiley   +1 more source

Redescription of Larval Development in Cultured Pearl Oyster Pinctada maxima

Ilmu Kelautan, 2018
Larval development plays a major role in efficient pearl culture. The cultured larvae will be later used for recipient and donor oysters in cultured pearl production. Larval developmental stage of silver lip pearl oyster Pinctada maxima has been reported
Jeane Siswitasari Mulyana, Achmad Farajallah, Yusli Wardiatno   +2 more
doaj   +1 more source

Cloning and functional characterization of PmΔ5FAD in pearl oyster Pinctada fucata martensii

Aquaculture Reports, 2022
Pinctada fucata martensii produces high-quality pearls. However, excess immune and inflammatory response after grafting operation will lead to nucleus rejection, pearl sac formation failure, and death of the host pearl oyster. Polyunsaturated fatty acids
Chuangye Yang, Ruijuan Hao, Chengzhang He, Yuewen Deng, Qingheng Wang   +4 more
doaj   +1 more source

A Solution for Exosome‐Based Analysis: Surface‐Enhanced Raman Spectroscopy and Artificial Intelligence

Advanced Intelligent Discovery, EarlyView.
Exosomes are emerging as powerful biomarkers for disease diagnosis and monitoring. This review highlights the integration of surface‐enhanced Raman spectroscopy with artificial intelligence to enhance molecular fingerprinting of exosomes. Machine learning and deep learning techniques improve spectral interpretation, enabling accurate classification of ...
Munevver Akdeniz, Zakarya Al‐Shaebi, Omer Aydin   +2 more
wiley   +1 more source

The immunomodulatory effects of L-carnitine on the immune responses induced by LPS and transplantation in the pearl oyster Pinctada fucata martensii

Aquaculture Reports
L-carnitine (LC) is a natural antioxidant that plays an important role in improving the antioxidant capacity of organisms and regulating the immune response.
Weijiang Liao, Jianuo Wu, Xiaojun Liu, Mingtao Zhang, Ming Zhang, Yu Jiao, Qingheng Wang, Chuangye Yang, Yuewen Deng   +8 more
doaj   +1 more source

Enhancement of Short Chain Fatty Acid Production by Co-cultures of Probiotics Fermentation with Pearl Millet (Pennisetum glaucum) Fibre Fractions

Journal of Pure and Applied Microbiology, 2017
Pearl millet dietary fibre fermentation using four co-culture of three probiotic strains Lactobacillus rhamnosus, Bifidobacterium longum, Bifidobacterium bifidus was studied for production of short chain fatty acids (SCFA).
Umar Farooq, Xiaoming Liu, Hao Zhang
doaj   +1 more source