Results 41 to 50 of about 6,153 (148)

The treatment and prognosis of pediatric adrenocortical carcinoma

Holistic Integrative Oncology
Abstract This review comprehensively assesses the treatment modalities and prognostic outcomes of pediatric adrenocortical carcinoma (ACC), a rare malignancy with significant clinical challenges. Through a systematic literature search of PubMed using the term "childhood adrenocortical carcinoma," supplemented by EndNote-assisted duplicate ...
Yu Lin, Kairui Zhai, Zhiyun Zhu, Jianyu Han, Shen Yang, Paul D. Losty, Hong Qin   +6 more
openaire   +1 more source

Psychosocial burdens and unmet supportive care needs of partners and relatives of individuals with Li‐Fraumeni syndrome: A mixed‐methods study

Journal of Genetic Counseling, Volume 34, Issue 6, December 2025.
Abstract Li‐Fraumeni syndrome (LFS) is a rare but highly penetrant cancer predisposition syndrome caused by pathogenic variants in the tumor suppressor gene TP53. Individuals diagnosed with LFS should adhere to intense surveillance programs for early tumor detection. The literature highlights several psychosocial challenges for this group. However, the
Senta Kiermeier, Sarah Schott, Juliane Nees, Christina M. Dutzmann, Farina Silchmüller, Christian P. Kratz, Myriam Keymling, Imad Maatouk   +7 more
wiley   +1 more source

The Pathophysiology and Treatment of Hypertension in Patients With Cushing's Syndrome [PDF]

, 2019
When hypertension, a pathology that is frequently found in the general population, presents in a young patient, secondary causes such as Cushing's syndrome (CS), a rare disease characterized by long-term elevated cortisol levels, should be considered ...
Barbot, Mattia, Ceccato, Filippo, Scaroni, Carla   +2 more
core   +1 more source

Elevated Prolactin Levels Are Associated With Increased Severity and Psychiatric Symptoms in Anti‐N‐Methyl‐D‐Aspartate Receptor Encephalitis

Brain and Behavior, Volume 15, Issue 11, November 2025.
Association of serum PRL with anti‐NMDAR encephalitis. ABSTRACT Background Autoimmune encephalitis, predominantly anti‐N‐methyl‐D‐aspartate receptor (anti‐NMDAR) encephalitis, is a central nervous system (CNS) autoimmune disorder. Prolactin (PRL), a pro‐inflammatory hormone implicated in autoimmune pathogenesis, may play a role in anti‐NMDAR ...
Xiaoyu Ma, Yaxin Lu, Yingying Xu, Shougang Guo, Weiqi Wang, Wei Shang, Wei Qiu, Pin Wang, Yaqing Shu, Yuge Wang   +9 more
wiley   +1 more source

A Hybrid Machine Learning-Based Method for Classifying the Cushing's Syndrome With Comorbid Adrenocortical Lesions [PDF]

, 2011
Background: The prognosis for many cancers could be improved dramatically if they could be detected while still at the microscopic disease stage. It follows from a comprehensive statistical analysis that a number of antigens such as hTERT, PCNA and Ki-67
Deng, Youping, Huang, Xudong, Li, Jianling, Luo, Zuojie, Ma, Yan, Yang, Jack Y, Yang, Mary Qu   +6 more
core   +1 more source

Stress and Support Present in Medical Crowdfunding in Pediatric Cancer

Cancer Reports, Volume 8, Issue 10, October 2025.
ABSTRACT Background Medical crowdfunding (MCF) seeks to mitigate the financial harm to families with a child with cancer. Aims We sought to describe the illness phases, campaign creators, and the main topics discussed on MCF pages. Methods and Results Using publicly available campaigns on GoFundMe.com, we randomly selected 100 campaigns to extract ...
Mary K. Killela, Sandra Garcia, Jessica Keim‐Malpass, Sandra Soto, Todd Schwartz, Jessica Williams, Sheila Santacroce   +6 more
wiley   +1 more source

Society for Endocrinology Clinical Practice Guideline for the Evaluation of Androgen Excess in Women

Clinical Endocrinology, Volume 103, Issue 4, Page 540-566, October 2025.
ABSTRACT Context Androgen excess is common in women and refers to clinical or biochemical evidence of elevated androgenic steroids such as testosterone. It is associated with underlying polycystic ovary syndrome in the majority of cases. However severe androgen excess is less common and may indicate the presence of underlying adrenal or ovarian ...
Yasir S. Elhassan, James M. Hawley, Leanne Cussen, Ali Abbara, Sophie A. Clarke, Punith Kempegowda, Rima K. Dhillon‐Smith, Puja Thadani, Maureen Busby, Lucy Owusu‐Darkwah, Rachel Marrington, W. Colin Duncan, Robert K. Semple, Richard Quinton, Michael W. O'Reilly   +14 more
wiley   +1 more source

Regarding the Children's Oncology Group ARAR0332 Protocol for Pediatric Adrenocortical Carcinoma [PDF]

Journal of Clinical Oncology, 2021
Ji-Gan Wang, Dun-Chang Mo
openaire   +2 more sources

Deciphering dual clinical entities associated with TP53 pathogenic variants: Insights from 53,085 HBOC panel analyses in French laboratories

International Journal of Cancer, Volume 157, Issue 5, Page 897-907, 1 September 2025.
What's new? TP53 is included in most cancer predisposition multigene panels, but analyzing the contribution of TP53 variants to cancer predisposition beyond the Li–Fraumeni syndrome remains challenging. This study, based on 53,085 hereditary breast and ovarian cancer panel analyses, explores the genotype–phenotype correlation of TP53 variants and ...
Edwige Kasper, Flavie Boulouard, Noémie Basset, Lisa Golmard, Hela Sassi, Emilie Bouvignies, Maud Branchaud, Camille Charbonnier, Nathalie Parodi, Marion Rolain, Juliette Albuisson, Ayman al Saati, Patrick Benusiglio, Pascaline Berthet, Marie Bidart, Céline Bonnet, Ahmed Bouras, Nadia Boutry‐Kryza, Fanny Brayotel, Virginie Bubien, Adrien Buisson, Laurent Castéra, Olivier Caron, Chrystelle Colas, Florence Coulet, Capucine Delnatte, Valentin Derangère, Alice Fievet, Céline Garrec, Marion Gauthier‐Villars, Mathilde Gay‐Bellile, Vincent Goussot, Jessica le Gall, Mathis Lepage, Anna Lokchine, Alexandre Perrier, Etienne Rouleau, Nicolas Sevenet, Dominique Stoppa‐Lyonnet, Jean‐Marie Ravel, Pierre Vande Perre, Dominique Vaur, Paul Vilquin, Gaëlle Bougeard, Stéphanie Baert‐Desurmont, Jean‐Christophe Thery, Claude Houdayer   +46 more
wiley   +1 more source

Mitotane Treatment for Malignant Leydig Cell Tumor: A Case Report

IJU Case Reports, Volume 8, Issue 5, Page 498-502, September 2025.
ABSTRACT Introduction Leydig cell tumors (LCTs), constituting 1%–3% of testicular tumors, are mostly benign, but malignant cases present treatment challenges. We report a malignant LCT case with a notable response to mitotane. Case Presentation A 43‐year‐old male presented with a right testicular induration and was diagnosed with a Leydig cell tumor ...
Daiki Katsura, Mototsugu Muramaki, Takashi Okamoto, Masaya Yamamoto, Mizuki Yutaka, Shohei Morita, Takuya Fujimoto, Yuji Yamada   +7 more
wiley   +1 more source