Results 91 to 100 of about 33,392 (283)
Development of a high-performance immunolatex based on “soft landing” antibody immobilization mechanism [PDF]
, 2012 Rabbit anti-human ferritin (anti-hFT) polyclonal immunoglobulin G (IgG) and poly(ethylene glycol) (PEG) were sequentially co-immobilized onto polystyrene submicroparticles (sMPs) to construct sMP/anti-hFT/PEG (SAP) immunolatex. Chemical immobilization of
Fabregat Dolça +4 more
core +1 more source
PEGylated Human Serum Albumin: Review of PEGylation, Purification and Characterization Methods [PDF]
Advanced Pharmaceutical Bulletin, 2016 Human serum albumin (HSA) is a non-glycosylated, negatively charged protein (Mw: about 65-kDa) that has one free cystein residue (Cys 34), and 17 disulfide bridges that these bridges have main role in its stability and longer biological life-time (15 to 19 days).
Parvin Akbarzadehlaleh +4 more
openaire +3 more sources
Advanced Science, EarlyView.This study presents a glutathione (GSH)‐activatable dual‐modality probe (GAP9) with a redox‐tuned activation window for precise tumor detection. It remains quenched (“OFF”) in normal tissue yet activates specifically in tumors for T1‐weighted magnetic resonance imaging (MRI) preoperative mapping and near‐infrared II (NIR‐II) fluorescence intraoperative
Haohao Yan +4 more
wiley +1 more source
An Expanded Toolbox for Versatile Chemical Editing of Adeno‐Associated Virus
Angewandte Chemie, EarlyView.We describe technology to introduce diverse non‐natural chemical functionalities site‐specifically into the capsid of adeno‐associated virus through genetic code expansion, and using them to engineer this leading vector for human gene therapy for enhanced tissue specificity and reduced immunogenicity Abstract Site‐specific incorporation of noncanonical
Quan Pham +6 more
wiley +2 more sources
Drug Delivery, 2018 Annonaceous acetogenins (ACGs) are one of the most active constituents isolated from Annona species with potent antitumor activity. However, the poor solubility and severe side effect greatly limit their use in clinic.
Haowen Li +6 more
doaj +1 more source
Protein PEGylation: Navigating Recombinant Protein Stability, Aggregation, and Bioactivity [PDF]
, 2022 Lindiwe Zuma +3 more
openalex +1 more source
Advanced Science, EarlyView.Fibronectin regulates the extracellular matrix (ECM)–myofibroblast cycle through three key steps: (1) its secretion and assembly by myofibroblasts (inhibited by pUR4); (2) collagen deposition along its scaffold (inhibited by R1R2); and (3) integrin α5β1‐mediated mechanotransduction (inhibited by ATN161).
Wenlong Ma +10 more
wiley +1 more source
Angewandte Chemie, EarlyView.Nanoparticle‐based tolerogenic vaccines harness controlled antigen delivery and immunomodulation to establish tolerance in autoimmunity and allergy. This review outlines how nanoparticle design (size, shape, composition, administration route) influences biodistribution and immune‐cell targeting.
Benjamin E. Nachod +3 more
wiley +2 more sources
Drug Design, Development and Therapy, 2017 Xiao Zhou, Hui Tao, Kai-Hu Shi Department of Cardiothoracic Surgery, The Second Hospital of Anhui Medical University, Hefei, People’s Republic of China Abstract: The aim of this study was to develop PEGylation liposomes formulations of erlotinib ...
Zhou X, Tao H, Shi KH
doaj
Experimental study of the acute toxicity of the oral form of pegylated interferon α2-b
Сибирский научный медицинский журнал, 2019 The aim of the study is to investigate the acute toxicity of the oral finished dosage form of pegylated interferon α-2b, obtained with the help of electron-beam synthesis technology. Material and methods.
D. N. Kinsht +4 more
doaj +1 more source