Results 91 to 100 of about 31,898 (250)

Folate-targeting annonaceous acetogenins nanosuspensions: significantly enhanced antitumor efficacy in HeLa tumor-bearing mice

Drug Delivery, 2018
Annonaceous acetogenins (ACGs) are one of the most active constituents isolated from Annona species with potent antitumor activity. However, the poor solubility and severe side effect greatly limit their use in clinic.
Haowen Li, Yijing Li, Hui Ao, Dongdong Bi, Meihua Han, Yifei Guo, Xiangtao Wang   +6 more
doaj   +1 more source

Extracellular Vesicles in Autoimmune Diseases: From Diagnostic Biomarkers to Engineered Therapeutics

Advanced Science, EarlyView.
This review provides a systematic comparison of extracellular vesicles (EVs) from both mammalian and plant sources in the context of autoimmune diseases. It highlights their emerging roles as precision biomarkers and engineered therapeutic platforms.
Yufei Wu, Huiyuan Ma, Tinghui Zhu, Shuwei Huang, Manxi Lu, Qiong Wang, Zai‐Long Chi   +6 more
wiley   +1 more source

Development of a nanoliposomal formulation of erlotinib for lung cancer and in vitro/in vivo antitumoral evaluation

Drug Design, Development and Therapy, 2017
Xiao Zhou, Hui Tao, Kai-Hu Shi Department of Cardiothoracic Surgery, The Second Hospital of Anhui Medical University, Hefei, People’s Republic of China Abstract: The aim of this study was to develop PEGylation liposomes formulations of erlotinib ...
Zhou X, Tao H, Shi KH
doaj  

Experimental study of the acute toxicity of the oral form of pegylated interferon α2-b

Сибирский научный медицинский журнал, 2019
The aim of the study is to investigate the acute toxicity of the oral finished dosage form of pegylated interferon α-2b, obtained with the help of electron-beam synthesis technology. Material and methods.
D. N. Kinsht, P. G. Madonov, T. S. Tartynova, A. A. Churin, E. Y. Sherstoboev   +4 more
doaj   +1 more source

Epidermal Growth Factor–PEG Functionalized PAMAM-Pentaethylenehexamine Dendron for Targeted Gene Delivery Produced by Click Chemistry [PDF]

, 2011
Aim of this study was the site-specific conjugation of an epidermal growth factor (EGF)-polyethylene glycol (PEG) chain by click chemistry onto a poly(amido amine) (PAMAM) dendron, as a key step toward defined multifunctional carriers for targeted gene ...
Balogh L., Bartlett D. W., Blessing T., Boeckle S., Boussif O., Carboni B., Carlin C. R., Choi J. S., Christian Dohmen, Davis M. E., Davis M. E., de Bruin K., Ernst Wagner, Esfand R., Haijun Yu, Hua C., Iyer J., Kannan R. M., Kataoka K., Kircheis R., Kircheis R., Kloeckner J., Kloeckner J., Kursa M., Lee J. W., Li S. D., Luo D., Lutz J. F., Maeda H., Maiti P. K., Meyer M., Navarro G., Nie Y., Ogris M., Plank C., Plank C., Russ V., Russ V., Russ V., Schaffert D., Shir A., Simoes S., Svenson S., Tomalia D. A., Tomalia D. A., von Gersdorff K., Wagner E., Wagner E., Walker G. F., Wolschek M. F., Wood K. C., Yellepeddi V. K., Yu H., Yu H., Yu Nie, Yunqiu Li, Zhang X. Q., Zhao X., Zou S. M., Zugates G. T.   +59 more
core   +1 more source

Cockroach‐Derived Leucokinin VIII Peptide Accelerates Diabetic Skin Wound Healing by Enhancing Keratinocyte Filopodia Formation

Advanced Science, EarlyView.
This study identifies the cockroach‐derived peptide leucokinin VIII as a potent accelerator of diabetic wound healing. By activating the FAK‐ACTG1 axis, the peptide drives keratinocyte migration and filopodia formation. Delivered via a developed PLGA‐PEG‐PLGA thermosensitive hydrogel for sustained release, this approach significantly hastens wound ...
Zhengshan Qin, Jinchuan Wu, Xiehua Xiao, Xirui Wang, Nianhui Ding, Xin Zhao, Lu Ma, Jie Li, Lunkun Ma, Cehua Ou, Ning Ma, Jianguo Feng   +11 more
wiley   +1 more source

Design, Synthesis and Characterization of Nano niosomal Delivery system Containing paclitaxel drug for Drug Delivery to Osteosarcoma Cell Line (Saos-2)

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2022
Introduction: Osteosarcoma is the most common type of bone cancer which current chemotherapy treatment strategies have not been very successful due to multiple drug resistance and diverse side effects.
Mohammad Javad Pourmahmoudian, Seyed Mahdi Kalantar, Bibi Fatemeh Haghiralsadat   +2 more
doaj  

Preclinical study of the toxicity of the oral form of pegylated interferon α-2b under its long-term use

Сибирский научный медицинский журнал, 2019
The aim of the study is to investigate the chronic toxicity of the oral finished dosage form of pegylated interferon α-2b, obtained with the help of electron-beam synthesis technology. Materials and methods.
A. A. Churin, E. Y. Sherstoboev, D. N. Kinsht, T. S. Tartynova, P. G. Madonov   +4 more
doaj   +1 more source

Stealth monoolein-based nanocarriers for delivery of siRNA to cancer cells [PDF]

, 2015
While the delivery of small interfering RNAs (siRNAs) is an attractive strategy to treat several clinical con- ditions, siRNA-nanocarriers stability after intravenous administration is still a major obstacle for the development of RNA-interference based ...
Allen, Ana C.N. Oliveira, Anbazhagan, Andreia C. Gomes, Bedi, Braeckmans, Braet, Bruno, Buyens, Buyens, Caracciolo, Carneiro, Chen, Cláudia Botelho, Copeland, Dominska, Fire, Grimm, Hafez, Hyvönen, Ivo Lopes, Kevin Braeckmans, Khatri, Koen Raemdonck, Koen Rombouts, Koynova, Kundu, Lam, Lassiseraye, Lau, Leal, Li, Li, Luzzati, M. Elisabete C.D. Real Oliveira, Marlene Lúcio, Mendonça, Mendonça, Naeye, Naeye, Oberle, Oliveira, Oliveira, Peeters, Pfaffl, Rejman, Remaut, Remaut, Resnier, Romberg, Rosana Simón-Vázquez, Shi, Silva, Silva, Silva, Silva, Silvius, Silvius, Simón-Vázquez, Song, Thomas Martens, Tseng, Vellón, Wang, Weisman, Wheeler, Whitehead, Yuan, Yuan, Zuhorn, África González-Fernández   +70 more
core   +1 more source

Nanozymes for Liver Disease Therapy: Advances in Catalytic Activity, Targeting Strategies, and Clinical Translation

Advanced Science, EarlyView.
Nanozymes, as enzyme‐mimicking nanomaterials, exhibit unique catalytic properties for the treatment of liver diseases. By regulating redox homeostasis, modulating immune responses, and enabling targeted delivery, nanozymes overcome the limitations of natural enzymes.
Xiandi Meng, Ge Zhu, Siyu Sun, Wenbo Yao, Yuning Zhang, Yong‐Guang Yang, Tianmeng Sun   +6 more
wiley   +1 more source