Results 111 to 120 of about 31,898 (250)
Cleavable PEGylation: a strategy for overcoming the “PEG dilemma” in efficient drug delivery
Drug Delivery, 2017 To prolong the circulation time of drug, PEGylation has been widely used via the enhanced permeability and retention (EPR) effect, thereby providing new hope for better treatment.
Yan Fang +7 more
doaj +1 more source
Molecules, 2019 Antigen-binding fragments of antibodies specific to the tumor-associated ganglioside GD2 are well poised to play a substantial role in modern GD2-targeted cancer therapies, however, rapid elimination from the body and reduced affinity compared to full ...
Irina V. Kholodenko +9 more
doaj +1 more source
Conformation and aggregation of selectively PEGylated and lipidated gastric peptide hormone human PYY3–36 [PDF]
, 2018 The gastric peptide hormone human PYY3–36 is a target for the development of therapeutics, especially for treatment of obesity. The conformation and aggregation behavior of PEGylated and lipidated derivatives of this peptide are examined using a ...
Beck-Sickinger, Annette G. +6 more
core +2 more sources
BMEMat, EarlyView.The immunosuppressive tumor microenvironment, characterized by hypoxia, redox imbalance, elevated interstitial fluid pressure, and acidity, was comprehensively elucidated. This review discussed the etiology and consequences of the characteristics of the immunosuppressive tumor microenvironment, and analyzed the recent advancements in nanomaterials for ...
Wen Zhang +7 more
wiley +1 more source
Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases
BMEMat, EarlyView.This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou +6 more
wiley +1 more source
Бюллетень сибирской медицины, 2018 The paper presents the results of investigation of immunotoxic action of interferon α-2b, immobilized in polyethylene glycol by means of electron-beam synthesis technology.Materials and methods.
D. N. Kinsht +6 more
doaj +1 more source
Quantifying the average number of nucleic acid therapeutics per nanocarrier by single particle tracking microscopy [PDF]
, 2018 Nucleic acid biopharmaceuticals are being investigated as potential therapeutics. They need to be incorporated into a biocompatible carrier so as to overcome several biological barriers. Rational development of suitable nanocarriers requires high-quality
Braeckmans, Kevin +9 more
core +2 more sources
BMEMat, EarlyView.This Perspective explores the emerging landscape of cell membrane‐coated nanoparticles (CM‐NPs) as intelligent, immune‐compatible platforms for cancer therapy. Highlighting design strategies, translational challenges, and competitive positioning, it outlines how integrating biomimetic targeting with advanced analytical and manufacturing tools could ...
A. K. M. M. Alam +4 more
wiley +1 more source
Peptide redesign for inhibition of the complement system: Targeting age-related macular degeneration. [PDF]
, 2016 PurposeTo redesign a complement-inhibiting peptide with the potential to become a therapeutic for dry and wet age-related macular degeneration (AMD).MethodsWe present a new potent peptide (Peptide 2) of the compstatin family.
Cabrera, Andrea P +6 more
core +1 more source
Biotechnology Progress, EarlyView.This work describes the development of human hemoglobin nanoparticles using an anti‐solvent precipitation synthesis method as a potential next generation hemoglobin‐based oxygen carrier. The hemoglobin nanoparticles are uniform in size and shape, hemocompatible, stable at various storage conditions, and demonstrate a scalable synthesis technique ...
Alisyn Greenfield, Andre F. Palmer
wiley +1 more source