Results 111 to 120 of about 33,392 (283)

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Breathing Life into Polycations [PDF]

, 2008
The lack of efficient delivery systems is still limiting the full therapeutic potential of siRNA. For the purpose of nucleic acid transfer, among other synthetic carrier systems, polycations have been applied.
Meyer, Martin, Oskuee, Reza, Philipp, Alexander, Schmidt, Claudia, Wagner, Ernst   +4 more
core   +1 more source

CXC Chemokine‐Driven Vascular Reprogramming: Modulating Tumor Vasculature to Boost Therapeutic Response

Advanced Science, EarlyView.
Tumor vascular remodeling is discussed from a chemokine‐centered perspective. This review summarizes the bidirectional, temporal, and tissue‐specific roles of CXC chemokines in regulating vascular function and immune accessibility. A functional vascular normalization score is introduced as a conceptual framework to integrate dynamic vascular and immune
Hongdan Chen, Yinde Huang, Juntong Wu, Ziying Yi, Yao Li, Zeyu Yang, Fan Zhang, Chong Li   +7 more
wiley   +1 more source

Improved Biological Impacts of Anti-EGFR Monoclonal Antibody in KRAS-Mutant Colorectal Cancer Cells by Silica-Coated Magnetic Nanoparticle Conjugation [PDF]

Pharmaceutical Sciences
Background: The therapeutic potential of epidermal growth factor receptor (EGFR) targeting in colorectal cancer (CRC) is hindered by the presence of KRAS codon 12 activating mutations, prevalent in approximately 25% of advanced CRC cases.
Maedeh Yousefi, Hamed Farzi-Khajeh, Mostafa Akbarzadeh-Khiavi, Azam Safary, Khosro Adibkia   +4 more
doaj   +1 more source

Quantifying the average number of nucleic acid therapeutics per nanocarrier by single particle tracking microscopy [PDF]

, 2018
Nucleic acid biopharmaceuticals are being investigated as potential therapeutics. They need to be incorporated into a biocompatible carrier so as to overcome several biological barriers. Rational development of suitable nanocarriers requires high-quality
Braeckmans, Kevin, De Smedt, Stefaan, Demeester, Jo, Dewitte, Heleen, Neyts, Kristiaan, Remaut, Katrien, Van Imschoot, Griet, Vandenbroucke, Roosmarijn, Vermeulen, Lotte, Zagato, Elisa   +9 more
core   +2 more sources

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

Surface‐Coated Inorganic Nanomaterials for Drug Delivery: Chemical Design, Biomedical Applications, and Mechanistic Insights

Advanced NanoBiomed Research, EarlyView.
This review explores how surface‐coated inorganic nanomaterials are chemically engineered for advanced drug delivery. It highlights design principles, coating strategies, and biomedical applications, emphasizing how surface chemistry governs biocompatibility, targeting, and controlled release.
Hossein Daneshgar, Sepideh Ahmadi, Nikzad Abbariki, Navid Rabiee, Sidi A. Bencherif   +4 more
wiley   +1 more source

Cleavable PEGylation: a strategy for overcoming the “PEG dilemma” in efficient drug delivery

Drug Delivery, 2017
To prolong the circulation time of drug, PEGylation has been widely used via the enhanced permeability and retention (EPR) effect, thereby providing new hope for better treatment.
Yan Fang, Jianxiu Xue, Shan Gao, Anqi Lu, Dongjuan Yang, Hong Jiang, Yang He, Kai Shi   +7 more
doaj   +1 more source

Engineering Ultrasound Contrast Agents for Targeted Therapeutics: A Theranostic Approach to Drug Delivery, Gene Therapy, and Immunomodulation

Advanced NanoBiomed Research, EarlyView.
Ultrasound contrast agents, including microbubbles and nanobubbles, transform imaging and targeted therapy through precise engineering of size, shell composition, and surface properties. This review explores how these innovations enable tissue‐specific delivery, enhance therapeutic efficacy, and extend applications from vascular imaging to tumor ...
Ashkan Seza, Kimia Mozahheb Yousefi, Sara Minaeian   +2 more
wiley   +1 more source

Epidermal Growth Factor–PEG Functionalized PAMAM-Pentaethylenehexamine Dendron for Targeted Gene Delivery Produced by Click Chemistry [PDF]

, 2011
Aim of this study was the site-specific conjugation of an epidermal growth factor (EGF)-polyethylene glycol (PEG) chain by click chemistry onto a poly(amido amine) (PAMAM) dendron, as a key step toward defined multifunctional carriers for targeted gene ...
Balogh L., Bartlett D. W., Blessing T., Boeckle S., Boussif O., Carboni B., Carlin C. R., Choi J. S., Christian Dohmen, Davis M. E., Davis M. E., de Bruin K., Ernst Wagner, Esfand R., Haijun Yu, Hua C., Iyer J., Kannan R. M., Kataoka K., Kircheis R., Kircheis R., Kloeckner J., Kloeckner J., Kursa M., Lee J. W., Li S. D., Luo D., Lutz J. F., Maeda H., Maiti P. K., Meyer M., Navarro G., Nie Y., Ogris M., Plank C., Plank C., Russ V., Russ V., Russ V., Schaffert D., Shir A., Simoes S., Svenson S., Tomalia D. A., Tomalia D. A., von Gersdorff K., Wagner E., Wagner E., Walker G. F., Wolschek M. F., Wood K. C., Yellepeddi V. K., Yu H., Yu H., Yu Nie, Yunqiu Li, Zhang X. Q., Zhao X., Zou S. M., Zugates G. T.   +59 more
core   +1 more source