Results 121 to 130 of about 31,898 (250)
PEGylation Promotes Hemoglobin Tetramer Dissociation
Bioconjugate Chemistry, 2009 Hemoglobin conjugated with poly(ethylene glycol) (PEG) acts as an oxygen carrier free in plasma, substituting red blood cells in supplementing oxygen in hypo-oxygenation pathologies. Given the complexity of oxygen delivery controls, subtle structural and functional differences in PEGylated hemoglobins might be associated with distinct physiological ...
D. Caccia +9 more
openaire +3 more sources
Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents
Chemistry – A European Journal, EarlyView.This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley +1 more source
Cancer Nexus, EarlyView.ABSTRACT Lipid nanoparticles (LNPs) represent the most clinically advanced platform for RNA delivery and have enabled major breakthroughs in vaccines and gene therapies. However, their broader application is still limited by inefficient extrahepatic delivery, immunogenicity, and insufficient control over tissue‐ and cell‐specific targeting. This review
Yu Han +5 more
wiley +1 more source
Food Biomacromolecules, EarlyView.Abstract This research describes the engineering of chitosan nanoparticles (CS NPs) via ionic gelation to encapsulate Ajwah seed extract (ASE), repurposing a plant waste product for its documented antioxidant and anticancer potential. Physicochemical analysis confirmed the formation of stable nanoparticles with hydrodynamic diameters between 152.3 and ...
Jailan E. Elhalawani +2 more
wiley +1 more source
Macromolecular Rapid Communications, EarlyView.Linear polyglycerol is proposed as a PEG‐alternative in mRNA‐loaded lipid nanoparticles to limit activation of anti‐PEG antibodies and reduce immunogenicity. Resulting nanoparticles may provide similar gene delivery capabilities, while preventing binding of anti‐PEG antibodies compared to PEGylated counterparts.
Yara Ensminger +8 more
wiley +1 more source
Macromolecular Rapid Communications, EarlyView.Arsonic acid containing diblock copolymers are developed to incorporate arsonic acid moieties for surface anchoring to IONPs, along with water soluble PEG blocks to impart colloidal stability in aqueous environments. The resulting polymer‐coated IONPs are evaluated for stability in physiological media and cytocompatibility.
Nhu Thao Huynh +10 more
wiley +1 more source
A Non‐Antigenic Randomized Polyethylene Glycol/Poly(2‐Phenyl‐2‐Oxazine)‐Based Drug Delivery Platform
Macromolecular Rapid Communications, EarlyView.Randomized PEG (rPEG), a conceptually new PEG alternative, is combined with poly(2‐phenyl‐2‐oxazine) (PPheOzi) to establish an rPEG‐b‐PPheOzi‐b‐rPEG micellar drug delivery platform. The PPheOzi block enables high drug loadings, while competitive ELISA reveals a drastic reduction in anti‐PEG antibody affinity of rPEG in comparison to PEG.
Julian Schmidt +6 more
wiley +1 more source
Small, EarlyView.ABSTRACT Yolk@shell nanostructures have emerged as promising platforms for biomedical applications due to their unique architecture, which combines the high surface area and loading capacity of hollow nanoparticles with the structural stability and functional versatility of core@shell systems. In this work, we report the synthesis of multifunctional Au@
Shoaib Azeem +4 more
wiley +1 more source
Research advances in the applications of mitochondria‐targeted cyanine dyes in imaging
VIEW, EarlyView.Near‐infrared (NIR) fluorescence imaging, a novel non‐invasive diagnostic tool, plays a crucial role in the imaging and monitoring of solid tumors. At its core are NIR fluorescent dyes, which are widely utilized due to their ability to minimize tissue autofluorescence interference, thereby significantly enhancing the signal‐to‐noise ratio (SNR) and ...
Hongye Liao +8 more
wiley +1 more source
PharmaceuticsBackground: Graphene Oxide (GO) has shown great potential in biomedical applications for cancer therapeutics. The biosafety and stability issues of GO in biological media have been addressed by functionalization with polyethylene glycol (PEG).
Athina Angelopoulou +6 more
doaj +1 more source