Results 11 to 20 of about 33,392 (283)

Polyethylene Glycol Camouflaged Earthworm Hemoglobin. [PDF]

, 2017
Nearly 21 million components of blood and whole blood and transfused annually in the United States, while on average only 13.6 million units of blood are donated. As the demand for Red Blood Cells (RBCs) continues to increase due to the aging population,
Cabrales, Pedro, Dantsker, David, Friedman, Joel M, Jani, Vivek P, Jelvani, Alborz, Moges, Selamawit, Nacharaju, Parimala, Palmer, Andre, Roche, Camille   +8 more
core   +8 more sources

Noncovalent PEGylation of l-Asparaginase Using PEGylated Polyelectrolyte [PDF]

Journal of Pharmaceutical Sciences, 2015
Noncovalent PEGylation has great potential for stabilization of therapeutic proteins. Here, we demonstrated that the noncovalent PEGylation with a PEGylated polyelectrolyte stabilized a therapeutic protein, l-asparaginase (ASNase). Anionic ASNase and cationic poly(ethylene glycol)-block-poly(N,N-dimethylaminoethyl methacrylate) (PEG-b-PAMA) formed a ...
Takaaki, Kurinomaru, Kentaro, Shiraki
openaire   +2 more sources

Blood clearance and tissue distribution of PEGylated and non-PEGylated gold nanorods after intravenous administration in rats\ud [PDF]

, 2011
Aims: To develop and determine the safety of gold nanorods, whose aspect ratios can be tuned to obtain plasmon peaks between 650 and 850 nm, as contrast enhancing agents for diagnostic and therapeutic applications.
Jong, Wim H. de, Krystek, Petra, Lankveld, Danielle P.K., Leeuwen, Ton G. van, Manohar, Srirang, Oomen, Agnes G., Rayavarapu, Raja G., Verharen, Hennie W.   +7 more
core   +8 more sources

To PEGylate or Not To PEGylate Therapeutics? [PDF]

Cell Chemical Biology, 2019
PEGylation is a common modulator of pharmacokinetics for therapeutic agents in vivo. In this issue of Cell Chemical Biology, Moreno et al. (2019) show anti-PEG antibodies may directly inhibit the activity of a PEGylated aptamer, RB006, both in vitro and in vivo, and the issues surrounding anti-PEG antibodies are discussed.
Keith E, Maier, Christopher P, Rusconi, Matthew, Levy   +2 more
openaire   +2 more sources

Polycaprolactone Nanoparticles as Promising Candidates for Nanocarriers in Novel Nanomedicines

Pharmaceutics, 2021
An investigation of the interactions between bio-polymeric nanoparticles (NPs) and the RAW 264.7 mouse murine macrophage cell line has been presented.
Sylwia Łukasiewicz, Antoni Mikołajczyk, Ewa Błasiak, Ewelina Fic, Marta Dziedzicka-Wasylewska   +4 more
doaj   +1 more source

Shrinkage of pegylated and non-pegylated liposomes in serum [PDF]

Colloids and Surfaces B: Biointerfaces, 2014
An essential requisite for the design of nanodelivery systems is the ability to characterize the size, homogeneity and zeta potential of nanoparticles. Such properties can be tailored in order to create the most efficient drug delivery platforms. An important question is whether these characteristics change upon systemic injection.
Wolfram J, Suri K, Yang Y, Shen J, CELIA, Christian, Fresta M, Zhao Y, Shen H, Ferrari M.   +8 more
openaire   +2 more sources

C-Terminal PEGylation Improves SAAP-148 Peptide’s Immunomodulatory Activities

Journal of Innate Immunity, 2023
Synthetic antibacterial and anti-biofilm peptide (SAAP)-148 was developed to combat bacterial infections not effectively treatable with current antibiotics. SAAP-148 is highly effective against antimicrobial-resistant bacteria without inducing resistance;
Miriam E. van Gent, Bep Schonkeren-Ravensbergen, Asma Achkif, Daan Beentjes, Natasja Dolezal, Krista E. van Meijgaarden, Jan Wouter Drijfhout, Peter H. Nibbering   +7 more
doaj   +1 more source

PEGylated gold nanoparticles-ribonuclease induced oxidative stress and apoptosis in colorectal cancer cells [PDF]

BioImpacts, 2020
Introduction: Currently, drug-induced reactive oxygen species (ROS) mediating apoptosis pathway have extensively been investigated in designing effective strategies for colorectal cancer (CRC) chemotherapy.
Mostafa Akbarzadeh Khiavi, Azam Safary, Jaleh Barar, Hamed Farzi-Khajeh, Abolfazl Barzegari, Rahimeh Mousavi, Mohammad Hossein Somi, Yadollah Omidi   +7 more
doaj   +1 more source

Genetic PEGylation

PLoS ONE, 2012
Polyethylene glycol (PEG) was genetically incorporated into a polypeptide. Stop-anticodon-containing tRNAs were acylated with PEG-containing amino acids and were then translated into polypeptides corresponding to DNA sequences containing the stop codons.
Tada, S., Andou, T., Suzuki, T., Dohmae, N., EIRY KOBATAKE, Ito, Y.   +5 more
openaire   +4 more sources

A novel solid-phase site-specific PEGylation enhances the in vitro and in vivo biostabilty of recombinant human keratinocyte growth factor 1. [PDF]

PLoS ONE, 2012
Keratinocyte growth factor 1 (KGF-1) has proven useful in the treatment of pathologies associated with dermal adnexae, liver, lung, and the gastrointestinal tract diseases. However, poor stability and short plasma half-life of the protein have restricted
Zhifeng Huang, Guanghui Zhu, Chuanchuan Sun, Jingui Zhang, Yi Zhang, Youting Zhang, Chaohui Ye, Xiaojie Wang, Dariush Ilghari, Xiaokun Li   +9 more
doaj   +1 more source