Results 61 to 70 of about 33,392 (283)
Advanced Functional Materials, EarlyView.MagPiezo enables wireless activation of endogenous Piezo1 channels without genetic modification using 19 nm magnetic nanoparticles and low‐intensity magnetic fields. It generates torque forces at the piconewton scale to trigger mechanotransduction in endothelial cells, standing as a novel platform to interrogate and manipulate Piezo1 activity in vitro.
Susel Del Sol‐Fernández +7 more
wiley +1 more source
Hyperpolarized Long-T1 Silicon Nanoparticles for Magnetic Resonance Imaging [PDF]
, 2009 Silicon nanoparticles are experimentally investigated as a potential hyperpolarized, targetable MRI imaging agent. Nuclear T_1 times at room temperature for a variety of Si nanoparticles are found to be remarkably long (10^2 to 10^4 s) - roughly ...
Akerman M. E. +32 more
core +2 more sources
PEGylated liposomes: immunological responses [PDF]
Science and Technology of Advanced Materials, 2019 A commonly held view is that nanocarriers conjugated to polyethylene glycol (PEG) are non-immunogenic. However, many studies have reported that unexpected immune responses have occurred against PEG-conjugated nanocarriers. One unanticipated response is the rapid clearance of PEGylated nanocarriers upon repeat administration, called the accelerated ...
Mohamed, Marwa +7 more
openaire +3 more sources
Advanced Healthcare Materials, EarlyView.Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee +9 more
wiley +1 more source
Melanocortin 1 receptor targeted imaging of melanoma with gold nanocages and positron emission tomography [PDF]
, 2018 Purpose: Melanoma is a lethal skin cancer with unmet clinical needs for targeted imaging and therapy. Nanoscale materials conjugated with targeting components have shown great potential to improve tumor delivery efficiency while minimizing undesirable ...
Black, Kvar +8 more
core +2 more sources
Surface functionalization with polyethylene glycol and polyethyleneimine improves the performance of graphene-based materials for safe and efficient intracellular delivery by laser-induced photoporation [PDF]
, 2020 Nanoparticle mediated laser-induced photoporation is a physical cell membrane disruption approach to directly deliver extrinsic molecules into living cells, which is particularly promising in applications for both adherent and suspension cells.
Boukherroub, Rabah +10 more
core +2 more sources
PEGylated Versus Non-PEGylated γ Fe2O3@Alendronate Nanoparticles [PDF]
Journal of Bioanalysis & Biomedicine, 2012 Thanks to their magnetic properties, superparamagnetic iron oxide nanoparticles are considered as a good delivery vehicle after grafting a therapeutical drug on their surface. For additional “stealth” characteristics, PEGylation of surfaces is necessary.
F, Benyettou +4 more
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement +12 more
wiley +1 more source
Current Issues in Molecular Biology, 2023 Oligomerization of antibody fragments via modification with polyethylene glycol (pegylation) may alter their function and properties, leading to a multivalent interaction of the resulting constructs with the target antigen.
Daniel V. Kalinovsky +8 more
doaj +1 more source
Artificial Extracellular Matrix Proteins Containing Phenylalanine Analogues Biosynthesized in Bacteria Using T7 Expression System and the PEGylation [PDF]
, 2011 In vivo incorporation of phenylalanine (Phe) analogues into an artificial extracellular matrix protein (aECM-CS5-ELF) was accomplished using a bacterial expression host that harbors the mutant phenylalanyl-tRNA synthetase (PheRS) with an enlarged binding
Furukawa, Yuya +6 more
core +2 more sources