Results 81 to 90 of about 31,898 (250)
Bolstering cholesteryl ester hydrolysis in liver: A hepatocyte-targeting gene delivery strategy for potential alleviation of atherosclerosis [PDF]
, 2017 Current atherosclerosis treatment strategies primarily focus on limiting further cholesteryl esters (CE) accumulation by reducing endogenous synthesis of cholesterol in the liver.
Ghosh, Shobha +5 more
core +2 more sources
Advanced Science, EarlyView.Microproteins are hidden treasures encoded by the “dark proteome” but remain largely underexplored due to the lack of highly efficient tools. We developed a molecularly imprinted polymers (MIPs)‐based toolbox (CLAIMID) to achieve accelerated and ultrasensitive microproteins validation at multiple biological scales (single living cells, cell populations,
Hui He +10 more
wiley +1 more source
PEGylated therapeutics in the clinic
Bioengineering & Translational MedicineThe covalent attachment of polyethylene glycol (PEG) to therapeutic agents, termed PEGylation, is a well‐established and clinically proven drug delivery approach to improve the pharmacokinetics and pharmacodynamics of drugs.
Yongsheng Gao +3 more
doaj +1 more source
Effect of PEGylation on assembly morphology and cellular uptake of poly ethyleneimine-cholesterol conjugates for delivery of sorafenib tosylate in hepatocellular carcinoma [PDF]
BioImpacts, 2018 Introduction: Sorafenib (SFB) is an FDA-approved chemotherapeutic agent with a high partition coefficient (log P = 4.34) for monotherapy of hepatocellular carcinoma (HCC).
Maryam Monajati +4 more
doaj +1 more source
Cell response to RGD density in cross-linked artificial extracellular matrix protein films [PDF]
, 2008 This study examines the adhesion, spreading, and migration of human umbilical vein endothelial cells on cross-linked films of artificial extracellular matrix (aECM) proteins.
Liu, Julie C., Tirrell, David A.
core +1 more source
PEGylated crosslinked hyaluronic acid nanoparticles designed through a microfluidic platform for nanomedicine [PDF]
, 2017 Aim: A high versatile microfluidic platform is proposed to design, in a one-step strategy, PEGylated crosslinked hyaluronic acid nanoparticles (cHANPs) entrapping a magnetic resonance imaging contrast agent and a dye for multimodal imaging applications.
Bevilacqua, Paolo +5 more
core +1 more source
Advanced Science, EarlyView.Fibronectin regulates the extracellular matrix (ECM)–myofibroblast cycle through three key steps: (1) its secretion and assembly by myofibroblasts (inhibited by pUR4); (2) collagen deposition along its scaffold (inhibited by R1R2); and (3) integrin α5β1‐mediated mechanotransduction (inhibited by ATN161).
Wenlong Ma +10 more
wiley +1 more source
Breathing Life into Polycations [PDF]
, 2008 The lack of efficient delivery systems is still limiting the full therapeutic potential of siRNA. For the purpose of nucleic acid transfer, among other synthetic carrier systems, polycations have been applied.
Meyer, Martin +4 more
core +1 more source
PEGylated Human Serum Albumin: Review of PEGylation, Purification and Characterization Methods [PDF]
Advanced Pharmaceutical Bulletin, 2016 Human serum albumin (HSA) is a non-glycosylated, negatively charged protein (Mw: about 65-kDa) that has one free cystein residue (Cys 34), and 17 disulfide bridges that these bridges have main role in its stability and longer biological life-time (15 to 19 days).
Parvin Akbarzadehlaleh +4 more
openaire +3 more sources
Advanced Science, EarlyView.Oral nanoCEL exhibits effective intestinal targeting of antigen‐presenting cells and restores the Th17/Treg balance in lymph nodes and spleen, ultimately protecting the blood‐retinal barrier by inhibiting peripheral immune cell infiltration and suppressing retinal glial cell activation.
Jinrun Chen +13 more
wiley +1 more source