The role of pendrin in blood pressure regulation [PDF]
American Journal of Physiology-Renal Physiology, 2016 Pendrin is a Na+-independent Cl−/HCO3−exchanger found in the apical regions of type B and non-A, non-B intercalated cells within the aldosterone-sensitive region of the nephron, i.e., the distal convoluted tubule (DCT), the connecting tubule (CNT), and the cortical collecting duct (CCD).
openaire +2 more sources
EFSA Journal, Volume 23, Issue 5, May 2025.Abstract The European Commission asked EFSA to update its 2014 risk assessment on perchlorate in food. Perchlorate is a contaminant of both natural and anthropogenic sources present in food and drinking water. It is a substrate for the sodium iodide symporter (NIS) and competitively inhibits the uptake of iodide into the thyroid.
EFSA Panel on Contaminants in the Food Chain (CONTAM) +27 more
wiley +1 more source
The Role of Epithelial Sodium Channel ENaC and the Apical Cl-/HCO3- Exchanger Pendrin in Compensatory Salt Reabsorption in the Setting of Na-Cl Cotransporter (NCC) Inactivation. [PDF]
PLoS ONE, 2016 The absence of NCC does not cause significant salt wasting in NCC deficient mice under basal conditions. We hypothesized that ENaC and pendrin play important roles in compensatory salt absorption in the setting of NCC inactivation, and their inhibition ...
Mina Patel-Chamberlin +5 more
doaj +1 more source
Mutations of Dual Oxidase 2 (DUOX2) Gene among patients with Permanent and Transient Congenital Hypothyroidism [PDF]
, 2012 Objective: The prevalence of congenital hypothyroidism (CH) is high in Isfahan, Iran. In addition, it has different etiologies compared with other countries. The rate of parental consanguinity is also high in the city. Moreover, DUOX2 gene is effective
Feizi, Awat. +6 more
core
New insights into sodium transport regulation in the distal nephron: Role of G-protein coupled receptors [PDF]
, 2016 International audienceThe renal handling of Na+ balance is a major determinant of the blood pressure (BP) level. The inability of the kidney to excrete the daily load of Na+ represents the primary cause of chronic hypertension.
Crambert, Gilles +2 more
core +4 more sources
Potentiation of the effect of thiazide derivatives by carbonic anhydrase inhibitors: molecular mechanisms and potential clinical implications. [PDF]
PLoS ONE, 2013 Carbonic anhydrase inhibitors (CAI) are mild diuretics, hence not widely used in fluid overloaded states. They are however the treatment of choice for certain non-kidney conditions.
Kamyar Zahedi +3 more
doaj +1 more source
Acidosis and Deafness in Patients with Recessive Mutations in FOXI1 [PDF]
, 2018 Maintenance of the composition of inner ear fluid and regulation of electrolytes and acid-base homeostasis in the collecting duct system of the kidney require an overlapping set of membrane transport proteins regulated by the forkhead transcription ...
Alkanderi, S +17 more
core
The gastric H,K-ATPase in stria vascularis contributes to pH regulation of cochlear endolymph but not to K secretion [PDF]
, 2016 Citation: Miyazaki, H., Wangemann, P., & Marcus, D. C. (2016). The gastric H,K-ATPase in stria vascularis contributes to pH regulation of cochlear endolymph but not to K secretion. BMC Physiology, 17(1), 1.
Marcus, Daniel C. +2 more
core +1 more source
Sensory Neuroscience, Volume 1, Issue 1, April 2025.Environmental factors and genetic factors damage the cochlear hair cells, which in turn leads to the death of sensory hair cells (This illustration was generated using Biorender.com). ABSTRACT Sensorineural hearing loss (SNHL) is a prevalent multifactorial condition affecting over 1.5 billion people worldwide.
Lin Yan +12 more
wiley +1 more source
Claudin expression during early postnatal development of the murine cochlea [PDF]
, 2018 Citation: Kudo, T., Wangemann, P., & Marcus, D. C. (2018). Claudin expression during early postnatal development of the murine cochlea. BMC Physiology, 18(1), 1.
Kudo, Takayuki +2 more
core +3 more sources